Results 11 to 20 of about 24,113 (256)
Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac [PDF]
MoleculesBackground: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare +5 more
doaj +2 more sources
Microsome Isolation from Tissue
Bio-Protocol, 2014 This protocol details the extraction of microsomes from frozen tissue in order to further examine the protein-protein interactions occurring within the endoplasmic reticulum. This protocol was adapted from Abisambra et al.
Maria Bodero, Jose Abisambra
doaj +4 more sources
Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay [PDF]
BMC Pharmacology and ToxicologyIntroduction 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis.
Yazun Jarrar +6 more
doaj +2 more sources
Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii [PDF]
BMC GenomicsBackground Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous and recalcitrant environmental pollutants generated from petroleum activities and/or biological conversion of organic materials.
Abdullahi Muhammad +5 more
doaj +2 more sources
Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood [PDF]
Veterinary QuarterlyFeline infectious peritonitis (FIP) is a potentially fatal coronavirus-driven disease of cats. Treatment with nucleoside analogue GS-441524 and or prodrug remdesivir (RDV) have produced remission in both experimentally induced and naturally occurring FIP,
Sally J. Coggins +5 more
doaj +2 more sources
Microbiology Spectrum, 2023 New antibacterial agents and agent combinations are urgently needed to combat antimicrobial resistance. A multidimensional chemical library screening strategy was used to identify compounds in the National Cancer Institute (NCI) diversity set V library ...
Shivani Gargvanshi +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs.
Fang-Ling Zhao +13 more
doaj +1 more source
Microbiology Spectrum, 2022 Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a recent study, a library screening strategy was developed in which an FDA-approved drug library was screened against ...
Shivani Gargvanshi, William G. Gutheil
doaj +1 more source
Liver kidney microsome antibodies. Analysis of a laboratory series
Practical Laboratory Medicine, 2023 Objectives: The objectives were to characterize the liver kidney microsome (LKM) antibody profile of a 14-month-old girl with autoimmune hepatitis and analyze the laboratory prevalence of LKM positivity. Design and methods: This is retrospective analysis
Sandra Sanchez +6 more
doaj +1 more source
Journal of Lipid Research, 2007 Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial ω-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E.
Timothy J. Sontag, Robert S. Parker
doaj +1 more source