Results 11 to 20 of about 32,983 (314)
Microsome Isolation from Tissue
BIO-PROTOCOL, 2014 This protocol details the extraction of microsomes from frozen tissue in order to further examine the protein-protein interactions occurring within the endoplasmic reticulum. This protocol was adapted from Abisambra et al. (2013) with modifications made in order to optimize for subsequent use.
Maria Bodero, Jose F. Abisambra
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Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac. [PDF]
MoleculesBackground: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Asare E +5 more
europepmc +2 more sources
Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood. [PDF]
Vet QFeline infectious peritonitis (FIP) is a potentially fatal coronavirus-driven disease of cats. Treatment with nucleoside analogue GS-441524 and or prodrug remdesivir (RDV) have produced remission in both experimentally induced and naturally occurring FIP,
Coggins SJ +5 more
europepmc +2 more sources
Microbiology Spectrum, 2022 Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a recent study, a library screening strategy was developed in which an FDA-approved drug library was screened against ...
Shivani Gargvanshi, William G. Gutheil
doaj +1 more source
Frontiers in Pharmacology, 2022 Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs.
Fang-Ling Zhao +13 more
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Microbiology Spectrum, 2023 New antibacterial agents and agent combinations are urgently needed to combat antimicrobial resistance. A multidimensional chemical library screening strategy was used to identify compounds in the National Cancer Institute (NCI) diversity set V library ...
Shivani Gargvanshi +3 more
doaj +1 more source
Microsomes, Microsomal Phospholipids, and Fatty Acid Synthesis [PDF]
Journal of Biological Chemistry, 1969 Abstract The effect of microsomes on fatty acid synthesis by the soluble fraction of rat liver cells has been studied. It was shown that the microsomes contain a heat-labile inhibitory factor, presumably ATPase, and a heat-stable stimulatory factor.
Daniel W. Foster, William P. McWhorter
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Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling [PDF]
, 2012 Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present
Cupitt, John +7 more
core +7 more sources
The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation
Czech Journal of Food Sciences, 2010 Isoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects.
Heya Wang +2 more
doaj +1 more source
Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior
Journal of Translational Medicine, 2023 Background Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-inflammatories in seedlings ...
Aleksandra A. Gurgul +6 more
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