Results 21 to 30 of about 74,782 (341)

Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase

Journal of Lipid Research, 2007
Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial ω-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E.
Timothy J. Sontag, Robert S. Parker
doaj   +1 more source

ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT

Journal of Lipid Research, 2003
Microsomal acyl CoA:cholesterol acyltransferase (AC57) is stimulated in vitro and/or in intact cells by proteins that bind and transfer both substrates, cholesterol, and fatty acyl CoA.
Hsu Chao, Minglong Zhou, Avery McIntosh, Friedhelm Schroeder, Ann B. Kier   +4 more
doaj   +1 more source

Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota

Molecules, 2022
The bioavailability of flavonoids is generally low after oral administration. The metabolic transformation of flavonoids by the gut microbiota may be one of the main reasons for this, although these metabolites have potential pharmacological activities ...
Adili Keranmu, Li-Bin Pan, Jie Fu, Pei Han, Hang Yu, Zheng-Wei Zhang, Hui Xu, Xin-Yu Yang, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Nian-Zeng Xing, Yan Wang   +13 more
doaj   +1 more source

Evaluation of Liver Microsomes for Genotoxicity Sensors—Voltammetry of the Microsomes [PDF]

The Electrochemical Society Interface, 2007
The 2007 Joseph W.
James F. Rusling, Sadagopan Krishnan
openaire   +2 more sources

The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation

Czech Journal of Food Sciences, 2010
Isoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects.
Heya Wang, Masibo Wanyonyi Martin, Shian Yin   +2 more
doaj   +1 more source

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Cheng, CH, Lam, RY, Lin, ZX, Sviderskaya, EV   +3 more
core   +2 more sources

LC-HRMS-Based Identification of Transformation Products of the Drug Salinomycin Generated by Electrochemistry and Liver Microsome

Antibiotics, 2022
The drug salinomycin (SAL) is a polyether antibiotic and used in veterinary medicine as coccidiostat and growth promoter. Recently, SAL was suggested as a potential anticancer drug.
Lisa Knoche, Jan Lisec, Tanja Schwerdtle, Matthias Koch   +3 more
doaj   +1 more source

Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa [PDF]

, 1977
Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic ribosomes are transferred into the mitochondrial fraction.
Andrews T. M., Bingham R. W., Blair G. E., Davidian N. M., Dobberstein B., Dolken G., Gaitskhoki V. S., Godinot C., Gonzalez-Cadavid N. F., Gonzalez-Cadavid N. F., Grollmann A. P., Hallermayer G., Kadenbach B., Kadenbach B., Kadenbach B., Kellems R. E., Kellems R. E., Kellems R. E., Kellems R. E., Marra E., Milstein C., Morris A., O'Brien R. L., Pfaff E., Redman C. M., Shore G. C., Takanami M., Tata J. R., Weiss H., Wojtczak L., Wojtczak L.   +30 more
core   +1 more source

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]

, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael, Gassaway, Madalee M., Grinnell, Steven G., Javitch, Jonathan A., Kruegel, Andrew C., Langreck, Cory, Le Rouzic, Valerie, Majumdar, Susruta, Pasternak, Gavril W., Pekarskaya, Elizabeth A., Pintar, John E., Sames, Dalibor, Uprety, Rajendra   +12 more
core   +3 more sources

Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines

Cells, 2022
The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability ...
Sandy Lemm, Susanne Köhler, Robert Wodtke, Friedrich Jung, Jan-Heiner Küpper, Jens Pietzsch, Markus Laube   +6 more
doaj   +1 more source