Results 21 to 30 of about 50,037 (190)

Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines

open access: yesCells, 2022
The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability ...
Sandy Lemm   +6 more
doaj   +1 more source

Isolation of Cytosol, Microsome, Free Polysomes (FPs) and Membrane-bound Polysomes (MBPs) from Arabidopsis Seedlings

open access: yesBio-Protocol, 2017
The plant endomembrane system plays vital roles for synthesis, modification and secretion of proteins and lipids. From the classic view, only mRNAs encoding secreted proteins could be targeted to the endoplasmic reticulum (ER) for translation via a co ...
Yonghui Zhao, Shengben Li
doaj   +1 more source

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1976
About 300 carcinogens and non-carcinogens of a wide variety of chemical types have been tested for mutagenicity in the simple Salmonella/microsome test.
J. McCann, B. Ames
semanticscholar   +1 more source

Sorbitol and NaCl stresses affect free, microsome-associated and thylakoid-associated polyamine content in Zea mays and Phaseolus vulgaris

open access: yesActa Physiologiae Plantarum, 2012
Most of commercially important crops, including maize and common bean, are sensitive to water deficit and salinity. Polyamines are considered to be osmotic and salt tolerance modulators and biochemical indicators of these stresses.
J. Legocka, E. Sobieszczuk-Nowicka
semanticscholar   +1 more source

Effects of Kaempferia galanga L. and ethyl-p-methoxycinnamate (EPMC) [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2011
Kaempferia galanga L. (K. galanga L.), belonging to the Zingiberaceae family, has been widely used in Thai traditionalmedicine for treatment of hypertension, asthma, rheumatism, indigestion, cold and headache and relief abdominal pain.This study aimed to
Wanna Sirisangtragul   +1 more
doaj  

Characterization of Flavonoids and Naphthopyranones in Methanol Extracts of Paepalanthus chiquitensis Herzog by HPLC-ESI-IT-MSn and Their Mutagenic Activity

open access: yesMolecules, 2012
A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and naphthopyranone compounds.
Wagner Vilegas   +6 more
doaj   +1 more source

Assessment of Metabolic Interaction between Repaglinide and Quercetin via Mixed Inhibition in the Liver: In Vitro and In Vivo

open access: yesPharmaceutics, 2021
Repaglinide (RPG), a rapid-acting meglitinide analog, is an oral hypoglycemic agent for patients with type 2 diabetes mellitus. Quercetin (QCT) is a well-known antioxidant and antidiabetic flavonoid that has been used as an important ingredient in many ...
Ji-Min Kim   +4 more
doaj   +1 more source

The composition of rat liver microsomes. The structural proteins of rat liver microsomes [PDF]

open access: yesBiochemical Journal, 1969
1. The structural-protein component of microsomal membranes was isolated by three separate methods. Analysis by polyacrylamide-gel electrophoresis indicated that the microsomal structural component is made up of a heterogeneous group of proteins. These proteins were further characterized by their phospholipid-binding capacity.
J. K. Pollak, K. A. Ward
openaire   +3 more sources

Changes of microsomal membrane compositions modulate microsomal enzyme activity [PDF]

open access: yesPediatric Research, 1979
We have shown previously, that the activity of cerebrosulfotransferase (CST) a microsomal enzyme involved in myelin synthesis is modulated in vitro by the cholesterol-phospholipid ratio (C/P) in microsomal membranes. To further investigate this mechanism, we studied two different models: 1.) Removal of cholesterol by phospholipid micelles and 2 ...
H. Jutzi   +3 more
openaire   +2 more sources

Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: A second type of “autoimmune” hepatitis

open access: yesHepatology, 1987
Sixty‐five patients with histologically proven chronic active hepatitis of unknown cause but associated with the antiliver/kidney microsome antibody type 1, confirmed by immunofluorescence and immunoprecipitation, were selected as forming a special ...
J. Homberg   +13 more
semanticscholar   +1 more source

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