Results 21 to 30 of about 32,983 (314)

Biotransformation of Liquiritigenin into Characteristic Metabolites by the Gut Microbiota

Molecules, 2022
The bioavailability of flavonoids is generally low after oral administration. The metabolic transformation of flavonoids by the gut microbiota may be one of the main reasons for this, although these metabolites have potential pharmacological activities ...
Adili Keranmu, Li-Bin Pan, Jie Fu, Pei Han, Hang Yu, Zheng-Wei Zhang, Hui Xu, Xin-Yu Yang, Jia-Chun Hu, Hao-Jian Zhang, Meng-Meng Bu, Jian-Dong Jiang, Nian-Zeng Xing, Yan Wang   +13 more
doaj   +1 more source

Evaluation of Liver Microsomes for Genotoxicity Sensors—Voltammetry of the Microsomes [PDF]

The Electrochemical Society Interface, 2007
The 2007 Joseph W.
James F. Rusling, Sadagopan Krishnan
openaire   +2 more sources

Evaluation of Betulin Mutagenicity by Salmonella/Microsome Test [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: Betulin is a pentacyclic triterpene found in the outer barks of innumerous plants. This secondary metabolite is easily isolated from plants with the major interest in converting it to betulinic acid, which pharmacological properties were much ...
Edson Hideaki Yoshida, Natália Tribuiani, Giovana Sabadim, Débora Antunes Neto Moreno, Eliana Aparecida Varanda, Yoko Oshima-Franco   +5 more
doaj   +1 more source

LC-HRMS-Based Identification of Transformation Products of the Drug Salinomycin Generated by Electrochemistry and Liver Microsome

Antibiotics, 2022
The drug salinomycin (SAL) is a polyether antibiotic and used in veterinary medicine as coccidiostat and growth promoter. Recently, SAL was suggested as a potential anticancer drug.
Lisa Knoche, Jan Lisec, Tanja Schwerdtle, Matthias Koch   +3 more
doaj   +1 more source

DNA adducts in fish following an oil spill exposure [PDF]

, 2006
On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast.
A. Amat, A. Pfohl-Leszkowicz, B French, B Kurelec, B Kurelec, BP Lyons, BP Lyons, C Genevois, CA Rice, D Petrapiana, DH Phillips, DH Phillips, E Aas, E Randerath, EJ Stein, F Telli-Karakok, F Vincent, FJ Van Schooten, G Ericson, G Ericson, G Ericson, JS Harvey, K Boillot, L Mazeas, LD Peters, M. Castegnaro, MC Poirier, MM Bradford, MS Myers, PAEL Schilderman, PC Baumann, R Amara, RA Lyons, T Burgeot, T. Burgeot, U Varanasi, WL Reichert   +36 more
core   +1 more source

Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines

Cells, 2022
The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability ...
Sandy Lemm, Susanne Köhler, Robert Wodtke, Friedrich Jung, Jan-Heiner Küpper, Jens Pietzsch, Markus Laube   +6 more
doaj   +1 more source

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Cheng, CH, Lam, RY, Lin, ZX, Sviderskaya, EV   +3 more
core   +2 more sources

Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa [PDF]

, 1977
Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic ribosomes are transferred into the mitochondrial fraction.
Andrews T. M., Bingham R. W., Blair G. E., Davidian N. M., Dobberstein B., Dolken G., Gaitskhoki V. S., Godinot C., Gonzalez-Cadavid N. F., Gonzalez-Cadavid N. F., Grollmann A. P., Hallermayer G., Kadenbach B., Kadenbach B., Kadenbach B., Kellems R. E., Kellems R. E., Kellems R. E., Kellems R. E., Marra E., Milstein C., Morris A., O'Brien R. L., Pfaff E., Redman C. M., Shore G. C., Takanami M., Tata J. R., Weiss H., Wojtczak L., Wojtczak L.   +30 more
core   +1 more source

Analysis of AMB-FUBINACA Biotransformation Pathways in Human Liver Microsome and Zebrafish Systems by Liquid Chromatography-High Resolution Mass Spectrometry

Frontiers in Chemistry, 2019
In this study, the metabolic profiles of a new illicit drug AMB-FUBINACA were investigated using both human liver microsome and zebrafish models. Liquid chromatography Q Extractive HF Hybrid Quadrupole-Orbitrap mass spectrometry (LC-QE-HF-MS) was ...
Duo-qi Xu, Wen-fang Zhang, Jing Li, Ji-fen Wang, Shi-yang Qin, Jiang-hai Lu   +5 more
doaj   +1 more source

Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]

, 2020
microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha, Bhattacharyya, Suvendra N., Bose, Mainak, Chakrabarty, Yogaditya, Chatterjee, Susanta   +4 more
core