Results 1 to 10 of about 88,222 (340)

Oxidative decarboxylation of retinoic acid in microsomes of rat liver and kidney

open access: hybridJournal of Lipid Research, 1968
Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe2+, and is further stimulated by the presence of pyrophosphate.
Anita B. Roberts, Hector F. DeLuca
doaj   +2 more sources

Microsomes, Microsomal Phospholipids, and Fatty Acid Synthesis [PDF]

open access: yesJournal of Biological Chemistry, 1969
Abstract The effect of microsomes on fatty acid synthesis by the soluble fraction of rat liver cells has been studied. It was shown that the microsomes contain a heat-labile inhibitory factor, presumably ATPase, and a heat-stable stimulatory factor.
Daniel W. Foster, William P. McWhorter
openaire   +2 more sources

Contribution of Mass Spectrometry to the Advances in Risk Characterization of Marine Biotoxins: Towards the Characterization of Metabolites Implied in Human Intoxications

open access: yesToxins, 2023
A significant spread and prevalence of algal toxins and, in particular, marine biotoxins have been observed worldwide over the last decades. Marine biotoxins are natural contaminants produced during harmful algal blooms being accumulated in seafood, thus
Pablo Estevez, Ana Gago-Martinez
doaj   +1 more source

HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies

open access: yesMolecules, 2022
Capmatinib, a recently approved tyrosine kinase inhibitor, is used for the treatment of non-small cell lung cancer. We describe two new HPLC methods for capmatinib quantification in vivo and in vitro. HPLC with a fluorescence detection method was used to
Aref Zayed   +5 more
doaj   +1 more source

Structural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes

open access: yesAntioxidants, 2023
Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić   +3 more
doaj   +1 more source

Evaluation of Liver Microsomes for Genotoxicity Sensors—Voltammetry of the Microsomes [PDF]

open access: yesThe Electrochemical Society Interface, 2007
The 2007 Joseph W.
James F. Rusling, Sadagopan Krishnan
openaire   +2 more sources

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings

open access: yesFrontiers in Pharmacology, 2017
Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated.
Jie Li   +26 more
doaj   +1 more source

Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients [PDF]

open access: yesElectrophoresis 18 (31/03/1997) 307-16, 2006
Membrane and nuclear proteins of poor solubility have been separated by high resolution two-dimensional (2-D) gel electrophoresis. Isoelectric focusing with immobilized pH gradients leads to severe quantitative losses of proteins in the resulting 2-D map, although the resolution is usually high.
arxiv   +1 more source

NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)

open access: yesРоссийский паразитологический журнал, 2016
Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria
E. A. Burenina
doaj   +1 more source

Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study

open access: yesApplied Sciences, 2022
5-Aminoisoquinoline (5-AIQ) is a water-soluble, potent and selective Poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to study the inhibitory effect of PARPs enzyme.
Muzaffar Iqbal   +4 more
doaj   +1 more source

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