Results 1 to 10 of about 35,679 (167)

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]

Drug Dev Res
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Chenu E, Duffy J, Forkuo AD, Gbedema SY, Abdelall S, Wahajuddin M, Jones HS, Wright CW.   +7 more
europepmc   +2 more sources

Investigation of the Relevance of CYP3A4 Inhibition on the Pharmacokinetics of the Novel P2X3 Antagonist Filapixant: Results of In Vitro Explorations and a Fixed-Sequence Clinical Trial with Itraconazole in Healthy Volunteers. [PDF]

Int J Mol Sci
Francke K, Rottmann A, Klein S, Höchel J, Friedrich C.   +4 more
europepmc   +1 more source

Covalently Active Metabolites of Bisphenol A Analogs by Mass Spectrometry Diagnostic Ions: Possible Mechanisms of Their Toxicity. [PDF]

Chem Res Toxicol
He Q, Hu X, Li X, Li N, Wu JL.
europepmc   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +1 more source

A Human Mass Balance and Metabolism Study of [¹⁴C]-Ubrogepant in Healthy Male Adults. [PDF]

Clin Pharmacol Drug Dev
Boinpally RR, Rowe J, Chandrasekar P, White RB, Marcantonio EE, Trainor N, Liang Y, Maciolek C, Small JH, Houle R, Hafey MJ, Xie H, Yabut J, Fandozzi C.   +13 more
europepmc   +1 more source

Biochemical Properties and Substrate Specificity of Two Acyl-CoA:Lysophosphatidic Acid Acyltransferases (<i>Pt</i>ATS2a and <i>Pt</i>ATS2b) from Diatom <i>Phaeodactylum tricornutum</i>. [PDF]

Int J Mol Sci
Jasieniecka-Gazarkiewicz K, Połońska A, Gong Y, Banaś A.   +3 more
europepmc   +1 more source

Evaluation of in vitro drug-drug interactions of ivermectin and antimalarial compounds. [PDF]

Malar J
Tipthara P, Kullasakboonsri R, Kobylinski KC, Tarning J.   +3 more
europepmc   +1 more source

NAD(P)⁺-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite. [PDF]

Arch Toxicol
Wu Q, Fang JL, Nagumalli SK, Guo X, Beland FA.   +4 more
europepmc   +1 more source

Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs. [PDF]

Drug Metab Dispos
Kapelyukh Y, Gabel-Jensen C, MacLeod AK, Daniel Coquelin KS, Stojanovski L, Frame L, Tavendale A, Henderson CJ, Read KD, Wolf CR, Säll C.   +10 more
europepmc   +1 more source

Inhibitory effects of Δ8-tetrahydrocannabinol on major hepatic cytochrome P450 enzymes and implications for drug disposition. [PDF]

Drug Metab Dispos
Zhao M, Coates S, Bardhi K, Lazarus P.
europepmc   +1 more source