Results 1 to 10 of about 129,619 (377)

Lipid peroxide formation in microsomes. General considerations [PDF]

Biochemical Journal, 1969
1. Liver microsomes form lipid peroxide when incubated with ascorbate or NADPH, but not with NADH. Increasing the concentration of ascorbate beyond the optimum (0.5mm) decreases the rate of lipid peroxide formation, but this effect does not occur with ...
E.D. Wills
openalex   +2 more sources

Oxidative decarboxylation of retinoic acid in microsomes of rat liver and kidney

Journal of Lipid Research, 1968
Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe2+, and is further stimulated by the presence of pyrophosphate.
Anita B. Roberts, Hector F. DeLuca
doaj   +2 more sources

Vitamin K preserves gamma-glutamyl carboxylase activity against carbamylations in uremia: Implications for vascular calcification and adjunct therapies. [PDF]

Acta Physiol (Oxf)
The source of the GGCX protein structure is uniprot, (image in the upper left of the graphical): this is the weblink: https://www.uniprot.org/uniprotkb/P38435/entry Abstract Aim Vascular calcification contributes to morbidity and mortality in aging and is accelerated in diabetes and in chronic kidney disease. Matrix Gla Protein is a potent inhibitor of
Kaesler N, Kaushik S, Frisch J, Ziegler S, Grommes J, Gombert A, Roma LP, Kuppe C, Jankowski J, Floege J, de la Puente-Secades S, Kramann R, Jankowski V.   +12 more
europepmc   +2 more sources

Inhibition of Steroidogenesis in Prostate Cancer Cells by Both a Natural and Another Synthetic Steroid. [PDF]

Drug Dev Res
ABSTRACT Studies suggest that vegetarians and Asians have lower mortality rates from prostate cancer compared to men who follow a Western diet. β‐sitosterol, a key compound of plant‐based diets, has been found to induce significant changes in the ultrasonic structure of the prostatic adenomas, making it a promising candidate for further prostate cancer
Cabeza M, Mejía K, García F, Heuze I, Morales M, Rodríguez-Dorantes M.   +5 more
europepmc   +2 more sources

In Vitro Evaluation of CYP-Mediated Metabolism of Fezolinetant and Pharmacokinetic Interaction Between Fezolinetant and Fluvoxamine in Healthy Postmenopausal Smokers and Nonsmokers. [PDF]

J Clin Pharmacol
Abstract Fezolinetant is an oral, nonhormonal, neurokinin 3 receptor antagonist treatment option for moderate to severe vasomotor symptoms associated with menopause. An in vitro study using human recombinant cytochrome P450 (CYP) enzymes and human liver microsomes showed that fezolinetant is metabolized to its major but inactive metabolite, ES259564 ...
Iwai M, Nielsen J, Miyagawa M, Patton M, Bonate PL, Wang X, Wojtkowski T, Sinn A, Huang J.   +8 more
europepmc   +2 more sources

Microsomes, Microsomal Phospholipids, and Fatty Acid Synthesis [PDF]

Journal of Biological Chemistry, 1969
Abstract The effect of microsomes on fatty acid synthesis by the soluble fraction of rat liver cells has been studied. It was shown that the microsomes contain a heat-labile inhibitory factor, presumably ATPase, and a heat-stable stimulatory factor.
Daniel W. Foster, William P. McWhorter
openaire   +2 more sources

Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study

Applied Sciences, 2022
5-Aminoisoquinoline (5-AIQ) is a water-soluble, potent and selective Poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to study the inhibitory effect of PARPs enzyme.
Muzaffar Iqbal, Essam A. Ali, Mohd Abul Kalam, Sheikh F. Ahmad, Rashad Al-Salahi   +4 more
doaj   +1 more source

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

Self Cycloaddition of o‐Naphthoquinone Nitrosomethide to (±) Spiro{naphthalene(naphthopyranofurazan)}‐one Oxide: An Insight into its Formation

ChemPlusChem, Volume 87, Issue 12, December 2022., 2022
2‐Hydroxy‐1‐naphthaldehyde oxime was oxidized by a D−A type self cycloaddition to spiro compound. Free reaction energy is calculated at −82.0 kcal/mol indicating its predominance over the intramolecular cyclization of −37.6 kcal/mol. 8‐methoxy substituted oxime is sterically guided to 9‐methoxynaphtho[1,2‐d] instead of spiro adduct resulting to the ...
Demeter Tzeli, Ioannis E. Gerontitis, Ioannis D. Petsalakis, Petros G. Tsoungas, George Varvounis   +4 more
wiley   +1 more source

HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies

Molecules, 2022
Capmatinib, a recently approved tyrosine kinase inhibitor, is used for the treatment of non-small cell lung cancer. We describe two new HPLC methods for capmatinib quantification in vivo and in vitro. HPLC with a fluorescence detection method was used to
Aref Zayed, Sana’a A. Jaber, Jomana Al Hroot, Sahar Hawamdeh, Nehad M. Ayoub, Nidal A. Qinna   +5 more
doaj   +1 more source