Results 161 to 170 of about 26,828 (241)

5'-Nucleotidase of Rat Liver Microsomes [PDF]

Journal of Biological Chemistry, 1960
B. Morton Brenner, Harold L. Segal
openaire   +2 more sources

LY354740, an agonist of glutamatergic metabotropic receptor mGlu_2/3 increases the cytochrome P450 2D (CYP2D) activity in the frontal cortical area of rat brain. [PDF]

Pharmacol Rep
Bromek E, Haduch A, Pukło R, Daniel WA.
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of long‐acting injectable cabotegravir and rilpivirine in pregnancy

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 989-1002, April 2025.
Aims Long‐acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use in pregnancy are limited. Physiologically‐based pharmacokinetic (PBPK) modelling was used to simulate the approved dosing regimens in pregnancy and explore if Ctrough was maintained above cabotegravir and rilpivirine target ...
Shakir Atoyebi, Fazila Bunglawala, Nicolas Cottura, Sandra Grañana‐Castillo, Maiara Camotti Montanha, Adeniyi Olagunju, Marco Siccardi, Catriona Waitt   +7 more
wiley   +1 more source

1-methylnicotinamide modulates IL-10 secretion and voriconazole metabolism. [PDF]

Front Immunol
Deng X, Li Y, Jiang L, Xie X, Wang X.
europepmc   +1 more source

AI‐Driven Applications in Clinical Pharmacology and Translational Science: Insights From the ASCPT 2024 AI Preconference

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Artificial intelligence (AI) is driving innovation in clinical pharmacology and translational science with tools to advance drug development, clinical trials, and patient care. This review summarizes the key takeaways from the AI preconference at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2024 Annual Meeting in ...
Mohamed H. Shahin, Prashant Desai, Nadia Terranova, Yuanfang Guan, Tomáš Helikar, Sebastian Lobentanzer, Qi Liu, James Lu, Subha Madhavan, Gary Mo, Flora T. Musuamba, Jagdeep T. Podichetty, Jie Shen, Lei Xie, Mathew Wiens, Cynthia J. Musante   +15 more
wiley   +1 more source

Biochemical characterization of the human ubiquitous glucose-6-phosphatase in neutrophil granulocytes. [PDF]

FEBS Open Bio
Lédeczi Z, Németh K, Kardon T.
europepmc   +1 more source

Tspo Depletion Exacerbates Steatosis Through Fatty Acid Uptake

Journal of Cellular and Molecular Medicine, Volume 29, Issue 7, April 2025.
ABSTRACT Previous studies demonstrated that Tspo loss causes simple steatosis (SS) in hepatocytes in vitro. However, its effect on SS in vivo remains unclear. In this study, we hypothesise that Tspo loss promotes early‐stage MASLD. WT and Tspo KO rats were fed a Gubra Amylin NASH (GAN) diet for 8 weeks to induce SS.
Yuchang Li, Liting Chen, Chantal Sottas, Nrupa Dinesh Patel, Mahima Chandrakant Raul, Vassilios Papadopoulos   +5 more
wiley   +1 more source

In Vitro Evaluation of the Safety and Antineoplastic Effects in Gastrointestinal Tumors of Nanostructured Lipid Carriers Loaded with Berberine. [PDF]

Pharmaceutics
Stefanova D, Yordanov Y, Bogdanova R, Voycheva C, Tzankov B, Popova T, Kondeva-Burdina M, Tzankova V, Toncheva-Moncheva N, Tzankova D, Slavkova M.   +10 more
europepmc   +1 more source

Endogenous Ethanol Production in the Human Alimentary Tract: A Literature Review

Journal of Gastroenterology and Hepatology, Volume 40, Issue 4, Page 783-790, April 2025.
ABSTRACT Endogenous ethanol production, or auto‐brewery syndrome (ABS), is a rare condition of the human alimentary canal that results in intoxication without alcohol consumption. Despite its clinical significance, ABS remains largely undiagnosed because of a lack of awareness among clinicians.
Renee Stamation
wiley   +1 more source

In vitro hydrolysis of areca nut xenobiotics in human liver. [PDF]

Drug Metab Pharmacokinet
Paolillo V, Jayakumar M, Sheperd C, Tran A, Hoang S, Dao N, Jain P, Myers AL.   +7 more
europepmc   +1 more source