Results 161 to 170 of about 1,677,689 (317)
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Adult patients with anaplastic lymphoma kinase positive (ALK+) advanced non–small‐cell lung cancer (NSCLC) are treated with 600 mg alectinib twice daily (BID) as first‐line treatment. ALK positive solid and central nervous system (CNS) tumors are described in the pediatric population, with limited clinical data due to the rarity of the disease
Tamara van Donge +6 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu +12 more
wiley +1 more source
Sidedness of ceramide-phosphoethanolamine synthesis on rat liver and brain microsomal membranes.
Journal of Lipid Research, 1987 Phosphatidylethanolamine:ceramide-ethanolamine-phosphotransferase catalyzes the synthesis of ceramide-phosphoethanolamine, a sphingomyelin analogue. Its localization was studied in rat liver and brain microsomes.
M Malgat, A Maurice, J Baraud
doaj
Pediatric Autoimmune Pancreatitis: Clinical Findings and Outcomes in Sweden
United European Gastroenterology Journal, EarlyView.ABSTRACT Introduction Pediatric autoimmune pancreatitis (AIP) is a rare form of pancreatitis in children with poorly understood pathophysiology. It is a recognized risk factor for chronic pancreatitis in approximately 4% of pediatric cases. This study aims to describe the demographics, clinical characteristics, and outcomes of a large Swedish cohort of
Miroslav Vujasinovic +9 more
wiley +1 more source
Top-K Maximum Intensity Projection Priors for 3D Liver Vessel Segmentation [PDF]
arXivLiver-vessel segmentation is an essential task in the pre-operative planning of liver resection. State-of-the-art 2D or 3D convolution-based methods focusing on liver vessel segmentation on 2D CT cross-sectional views, which do not take into account the global liver-vessel topology.
arxiv
FASEB BioAdvances, EarlyView.Prolonged fasting and fibrate treatment induce peroxisomal β‐oxidation and lead to excessive generation of hydrogen peroxide, which stimulates ethanol metabolism and significantly increases the formation of acetaldehyde; further oxidation of acetaldehyde into acetate remarkably elevates the mitochondrial ratio of NADH/NAD+ and causes feedback ...
Yida Zhang +6 more
wiley +1 more source
Journal of Lipid Research, 1998 In vitro techniques have been used to investigate the nature of microsomal cytochrome P450 involved in the metabolism of oleic acid, a physiological monounsaturated fatty acid. Like lauric acid, which is cur rently used as a model substrate of fatty acid
Fadi Adas +5 more
doaj
Integrative Zoology, EarlyView.The gut microbiota regulates lipid metabolism of Gansu zokor (Eospalax cansus) through the bile acid pathway in hypoxic environments, reflecting the unique survival strategy of subterranean rodents to maintain lipid metabolism homeostasis and flexible energy metabolism in hypoxic environments.
Maohong Yang +5 more
wiley +1 more source
Journal of Digestive Diseases, EarlyView.Mycophenolate mofetil (MMF) demonstrates superior efficacy and tolerability compared to azathioprine (AZA) in treatment‐naïve autoimmune hepatitis (AIH) patients. Meta‐analysis of five studies reveals higher complete biochemical response rates, increased Corticosteroid withdrawal rate, and fewer gastrointestinal side effects with MMF.
Muhammad Tayyab Anwar +12 more
wiley +1 more source