Results 161 to 170 of about 64,891 (274)

Investigation of the Relevance of CYP3A4 Inhibition on the Pharmacokinetics of the Novel P2X3 Antagonist Filapixant: Results of In Vitro Explorations and a Fixed-Sequence Clinical Trial with Itraconazole in Healthy Volunteers. [PDF]

Int J Mol Sci
Francke K, Rottmann A, Klein S, Höchel J, Friedrich C.   +4 more
europepmc   +1 more source

A Hemochromogen Component of Liver Microsomes [PDF]

Proceedings of the National Academy of Sciences, 1952
C F, Strittmatter, E G, Ball
openaire   +2 more sources

Quantitative Treatments for Explaining the Mechanism and Kinetics of Catalytic Electron Transfers in Murburn Processes, Particularly Involving Heme Enzymes Like (Per)oxidases and P450s

BioMed Research International, Volume 2026, Issue 1, 2026.
The seminal Michaelis–Menten theorization for biological catalysis was based on “transition state” (TS), involving the formation of a topologically complementary substrate (S) and enzyme (E) complex (ES) at the “active site” of the latter. Rudolph Marcus put forth the theory of outer sphere electron transfer (ET) in a “donor–acceptor” TS complex, which
Kelath Murali Manoj, Daniel Andrew Gideon, Philip Moses Samuel, Suhotra Das, Nahit Gencer   +4 more
wiley   +1 more source

The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +1 more source

The Diagnostic Value of Colorectal Cancer Using SAA, MIC‐1, CEA, and CA125

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Background Colorectal cancer (CRC) is often diagnosed at advanced stages due to the lack of early symptoms. Conventional screening methods have limitations in sensitivity and patient compliance. Tumor biomarkers may provide a less invasive and more accurate diagnostic approach.
Keming Zhang, Zengyao Li, Ye Zhang, Mengchen Xing, Suraiya Saleem   +4 more
wiley   +1 more source

Simvastatin Improves the High-Fat-Diet-Induced Metabolic Disorder in Juvenile Chinese Giant Salamander (<i>Andrias davidianus</i>) Through Inhibiting Endoplasmic Reticulum Stress and Enhancing Mitochondrial Function. [PDF]

Animals (Basel)
Wang Y, Chen J, Dong Y, Du J, Ma S, Wang H, Wang Y, Li X.   +7 more
europepmc   +1 more source

A New Cytochrome in Liver Microsomes

Journal of Biological Chemistry, 1962
T, OMURA, R, SATO
openaire   +2 more sources

Recent Advances in Photocatalytic Degradation of Caffeine: Overview of the Mechanism and Photocatalysts

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Caffeine, a widely consumed stimulant, has emerged as a recurring and persistent contaminant in aquatic environments, including surface water, groundwater and wastewater effluents. Its continuous presence poses ecological risks due to its bioactivity and resistance to conventional treatment methods.
Anusha D. Shetty, S. Nethaji, Harshini Dasari, Munmun Bardhan   +3 more
wiley   +1 more source

Impact of Dihydrocapsaicin on the Metabolism of Efavirenz In Vitro and In Vivo. [PDF]

Pharmacol Res Perspect
Wang B, Ma X, Wang X, Chen Y, Zhou Q, Al Mamun A, Wang G, Wang S, Ma X.   +8 more
europepmc   +1 more source

Safety of 6′‐sialyllactose (6′‐SL) sodium salt produced with a derivative strain (Escherichia coli K‐12 MG1655 INB‐6SL_02) of E. coli K‐12 MG1655 (ATCC 700926) as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 6′‐sialyllactose (6’‐SL) sodium salt as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the human‐identical milk oligosaccharide (HiMO) 6’‐SL (sodium salt),
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Thomas Frenzel, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Henk van Loveren, Estefanía Noriega Fernández, Karen Ildico Hirsch‐Ernst   +23 more
wiley   +1 more source