Results 171 to 180 of about 1,703,947 (251)
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Pigments of rat liver microsomes
Archives of Biochemistry and Biophysics, 1958Abstract The total hemin content of washed rat liver microsomes is 2.15 times the cytochrome b5 content, only a small part being due to bound hemoglobin. The content of flavine is 4 5 that of cytochrome b5. The flavine probably does not contribute to the DPNH reduced difference spectrum.
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Interaction of ranitidine with liver microsomes
Xenobiotica, 19821. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić +3 more
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Permeability of Liver Microsomal Membranes to Glucose
Biochemical and Biophysical Research Communications, 1996The permeability of rat liver microsomes to glucose has been studied by using (14)C-labelled D-glucose and a light-scattering technique. 1) The microsomal intravesicular apparent isotope space for D-glucose (1mM; after 5 min incubation at 22 degrees C) was 2.34 microl/mg protein, i.e., approximately 72% of the apparent water space.
MARCOLONGO, P. +4 more
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Mechanism of reduction of nitrofurantoin on liver microsomes
Pharmacological Research Communications, 1980Summary Reduction of the nitro-group of nitrofurantoin /N-[5-Nitro-2-furfuryliden-] 1-aminohydantoin/ on liver microsomes is supported both by NADPH and NADH. The site of interaction of nitrofurantoin with microsomes appears to be on two flavoproteins, NADPH-cytochrome P450 reductase and NADH-cytochrome b5 reductase; interaction with the former ...
M. Popović, V. Leskovac
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Chromate metabolism in liver microsomes
Biological Trace Element Research, 1979The carcinogenicity and mutagenicity of various chromium compounds have been found to be markedly dependent on the oxidation state of the metal. The carcinogen chromate was reduced to chromium(III) by rat liver microsomes in vitro. Metabolism of chromate by microsomal enzymes occurred only in the presence of either NADPH or NADH as cofactor.
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Activation of Thionophosphates by Liver Microsomes
Nature, 1959MANY organophosphorus insecticides are poor inhibitors of cholinesterase, but are converted to potent inhibitors (‘activated’) by certain mammalian and insect tissues. The activation by liver slices was first shown by Gardiner and Kilby1 for schradan (a phosphoroamidate), and by Diggle and Gage2 for parathion (a phosphorothionate). Davison3 showed that
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Microsomal antigens in developing chick liver
Experimental Cell Research, 1965Abstract Microsomes from embryonic and adult chick liver have been analyzed by homologous antisera. The deoxycholate-soluble fraction of embryonic microsomes contains a group of antigens typical to this fraction, but present only as a trace in the adult-homologous fraction.
E. Piazza, V. Mutolo, V. D'Amelio
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Metabolism of naphthalene by pigeon liver microsomes
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1979Abstract 1. Microsomal mixed-function oxidase of the pigeon liver shows maximum activity and stability at 44°C and 6.8 pH. Naphthalene is metabolized to 1-naphthol and 1,2-diol and a number of minor metabolites. The MFO activity and P-450 contents of pigeon liver microsomes, under optimum conditions show about 1 3 to 1 4 activity of ...
M.A.Q. Khan, J.C. Grossman
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Development of Liver Microsomal Oxidations in the Chick
Xenobiotica, 19761. Liver microsomal preparations from chick embryos (1 day before hatching) and from 1-7 day old chicks were assayed for oxidative drug-metabolizing activity with aminopyrine, aniline and naphthalene as substrates. 2. Activities for all three substrates were highest in preparations from 1 day-old chicks.
W. R. Jondorf +3 more
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Ethylene Formation in Rat Liver Microsomes
Science, 1966Reduced triphosphopyridine nucleotide and pyrophosphate-dependent peroxidation of lipids in rat liver microsomes were coupled to the generation of ethylene in the presence of cuprous ions. This system suggests a model for the biogenesis of ethylene in cells.
Paul Hochstein, Morris Lieberman
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