Results 171 to 180 of about 26,828 (241)

Disentangling Organ‐Specific Roles of Farnesoid X Receptor in Bile Acid and Glucolipid Metabolism

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Background and Aims The farnesoid X receptor (FXR) is an attractive pharmaceutical target for metabolic dysfunction‐associated steatotic liver disease (MASLD). However, its tissue‐specific roles in energy metabolism remain controversial, hindering the development of effective therapies. To address this, new approaches are required.
Tingting Li, Chenyang Fu, Zhongzheng Tang, Changkun Li, Duanyi Hua, Bei Liu, Zheying Tao, Jie Yang, Li Zhang, Tingting Cheng, Shujie Wang, Guang Ning, Yanyun Gu   +12 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of capsaicin for all animal species (XP Chemistries AB)

EFSA Journal, Volume 23, Issue 4, April 2025.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of capsaicin as a sensory feed additive for all animal species (flavouring compounds). The additive is specified to have a purity of at least 98% with a ratio of (E)‐capsaicin (trans‐capsaicin) to (Z)‐capsaicin (cis ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Maria Bastos, Georges Bories, Paul Brantom, Jürgen Gropp, Ruud Woutersen, Jaume Galobart, Paola Manini, Fabiola Pizzo, Maria Vittoria Vettori, Andrew Chesson   +26 more
wiley   +1 more source

Species Differences in Ezetimibe Glucuronidation. [PDF]

Metabolites
Emmanuel S, Asare EA, Du T, Xie H, Liang D, Gao S.   +5 more
europepmc   +1 more source

Safety and efficacy of a feed additive consisting of an essential oil derived from the leaves of Pogostemon cablin Benth. (patchouli oil) for use in all animal species (FEFANA asbl)

EFSA Journal, Volume 23, Issue 4, April 2025.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of patchouli oil from the leaves of Pogostemon cablin Benth. (patchouli oil) when used as a sensory additive in feed and in water for drinking for all animal species. The EFSA Panel on Additives and Products or Substances
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Maria de Lourdes Bastos, Paul Brantom, Andrew Chesson, Josef Schlatter, Johannes Westendorf, Paola Manini   +22 more
wiley   +1 more source

Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats. [PDF]

NPJ Sci Food
Zhang M, Du P, Xiao Y, Liu H, Wang M, Zhang Y, Chen X.   +6 more
europepmc   +1 more source

Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt. [PDF]

Int J Mol Sci
Li Y, Cotham WE, Eliasof A, Bland K, Walla M, Pellechia PJ, Chen C, Fan D, McLaughlin JP, Liu-Chen LY.   +9 more
europepmc   +1 more source

Preclinical evaluation of the potential PARP-imaging probe [carbonyl-¹¹C]DPQ. [PDF]

EJNMMI Radiopharm Chem
Benčurová K, Balber T, Weissenböck V, Kogler L, Friske J, Pichler V, Mitterhauser M, Hacker M, Philippe C, Ozenil M.   +9 more
europepmc   +1 more source

In vitro safety evaluation of dopamine D3R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder. [PDF]

PLoS One
Nandre RM, Newman AH, Terse PS.
europepmc   +1 more source

ChatGPT does make up scientific references: should it be currently renamed CheatGPT? [PDF]

Eur J Clin Pharmacol
Mikus G.
europepmc   +1 more source

Metabolism of acetanilide in liver microsomes

Japanese Journal of Pharmacology, 1976
Hiroshi Nakayama, Mutsuro Suzuki, Akio Ishida, Shozo Tanaka   +3 more
openaire   +2 more sources