Results 191 to 200 of about 1,677,689 (317)

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes [PDF]

, 2019
Bloom, Adam Joseph, Kharasch, Evan D, Wang, Pan-Fen   +2 more
core   +2 more sources

Investigations Into the Urinary Metabolite Elimination Profile of the Selective Androgen Receptor Modulator S‐23 in Studies Mimicking Contaminated Product Ingestion for Doping Control Purposes

Biomedical Chromatography, Volume 39, Issue 6, June 2025.
ABSTRACT Selective androgen receptor modulators (SARMs) have repeatedly been reason of adverse analytical findings (AAFs) in routine doping controls. Among these, S‐23 has been identified in five AAFs reported in 2022. In addition to intentional doping, inadvertent exposure through contaminated dietary supplements has emerged as a significant concern ...
Hana Alhalabi, Linus Korsmeier, Andreas Thomas, Mario Thevis   +3 more
wiley   +1 more source

Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy. [PDF]

Pharmaceutics
Wen D, Chen B, Deng M, Wu S, Xie S.
europepmc   +1 more source

Regulatory Effects of Betonica macrantha Extract, Known as Mountain Tea, on miRNA Expression and Its Pharmacokinetic Properties

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Betonica macrantha methanol extract exhibited anticancer activity against MDA‐MB‐231 breast cancer cells (IC50: 0.8 mg/mL), upregulating miR‐19, miR‐20a, miR‐126, and miR‐200c. GC–MS and HPLC analyses identified key bioactive compounds, including α‐pinene, caryophyllene, and catechin, which showed favorable pharmacokinetics and target interactions ...
Muhammed Emin Sarı, Emine Incilay Torunoğlu, Zeynep Betül Sarı, Erdi Can Aytar, Abidin Gümrükçüoğlu, Alper Durmaz, Gamze Demirel   +6 more
wiley   +1 more source

Subcellular Partitioning of Trace Elements Is Related to Metal Ecotoxicological Classes in Livers of Fish (<i>Esox lucius; Coregonus clupeaformis</i>) from the Yellowknife Area (Northwest Territories, Canada). [PDF]

Toxics
Rolland A, Palmer M, Chételat J, Amyot M, Rosabal M.   +4 more
europepmc   +1 more source

Exploring the Healing Potential of Aqueous Extract of Baccaurea ramiflora Leaves in Inflammation: A Cytokine and Prostaglandin Modulator

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study demonstrates that the aqueous extract of Baccaurea ramiflora leaves (BrLAE) possesses significant antioxidant and anti‐inflammatory properties. BrLAE treatment effectively reduced CFA‐induced paw edema, improved hematological and biochemical parameters, and downregulated pro‐inflammatory gene expression in Wistar rats.
Muhammad Nasir Hayat Malik, Md. Mahedi Hassan Tusher, Begum Rokeya, Sidra Javaid, Saud O. Alshammari, Amr S. Abouzied, Qamar A. Alshammari, Abdulkarim Alshammari, Maryam Zaib, Hafiz Muhammad Bilal, Muhammad Atif, Gideon F. B. Solre   +11 more
wiley   +1 more source

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set. [PDF]

Pharmaceuticals (Basel)
Maurer CK, Fang Z, Duevel HM, Harlfinger S, Petersson C.   +4 more
europepmc   +1 more source

Metabolite‐Based Network Pharmacology, Molecular Docking, and Dynamics Simulations to Preliminarily Verify Treating Diabetic Encephalopathy Effect of Kuwanon G

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study investigates the neuroprotective effects of Kuwanon G (KWG) against diabetic encephalopathy (DE) by characterizing its metabolic profile and therapeutic mechanisms. Using UHPLC‐Q‐TOF‐MS, network pharmacology, molecular docking, and dynamics simulations, 56 metabolites were identified, with nine showing high intestinal absorption and ...
Yuqian Zhang, Siying Zhang, Haiying Niu, Weiwei Xie, Yuxin Tan, Deqiang Li, Yiran Jin   +6 more
wiley   +1 more source

Mono-CYP CHO Model: A Recombinant Chinese Hamster Ovary Cell Platform for Investigating CYP-Specific Tamoxifen Metabolism. [PDF]

Int J Mol Sci
Schulz C, Stegen S, Jung F, Küpper JH.
europepmc   +1 more source

Clinical Assessment of the Drug–Drug Interaction Potential of Omaveloxolone in Healthy Adult Participants

The Journal of Clinical Pharmacology, Volume 65, Issue 6, Page 715-730, June 2025.
Abstract Omaveloxolone is approved in the United States and the European Union for the treatment of patients with Friedreich ataxia aged ≥16 years. It is mainly metabolized by cytochrome P450 (CYP) 3A4 in vitro. Two drug–drug interaction studies (NCT04008186 and NCT05909644) were performed to evaluate (1) the effect of drug‐metabolizing enzymes (DMEs ...
Hamim Zahir, Masako Murai, Lucy Wu, Michelle Valentine, Scott Hynes   +4 more
wiley   +1 more source