Results 251 to 260 of about 1,677,689 (317)

Interindividual variability in CYP3A-mediated venetoclax metabolism in vitro and in vivo in patients with chronic lymphocytic leukemia. [PDF]

Clin Transl Sci
Lee J, Beers JL, Cheng I, Truong V, Brown Z, Muluneh B, Coombs CC, Jackson KD.   +7 more
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Human and rat renal proximal tubule in vitro models for ADME applications. [PDF]

Arch Toxicol
Klatt OC, de Brouwer L, Hendriks F, Dehne EM, Ataç Wagegg B, Jennings P, Wilmes A.   +6 more
europepmc   +1 more source

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Metabolism of Dietary Flavonoids in Liver Microsomes

Current Drug Metabolism, 2013
Flavonoids undergo substantial hepatic metabolism and the metabolites might significantly contribute to the effects of these dietary constituents. The metabolites of flavonoids in liver can be summarized as follows: 1) For flavones, the hydroxylation appears to occur at the C-4'-, C-3', C-6 and C-8- position when there is a single or no hydroxy group ...
Jianbo Xiao, Petra Högger
openaire   +4 more sources

Characterized in Vitro Metabolism Kinetics of Alkyl Organophosphate Esters in Fish Liver and Intestinal Microsomes.

Environmental Science and Technology, 2018
Tris(2-butoxyethyl) phosphate (TBOEP) and tris( n-butyl) phosphate (TNBP) are the most commonly used alkyl organophosphate esters (alkyl-OPEs), and they increasingly accumulate in organisms and create potential health hazards.
Rui Hou, Chao Huang, Kaifeng Rao, Yiping Xu, Zijian Wang   +4 more
semanticscholar   +1 more source

Biotransformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) by human liver microsomes: identification of cytochrome P450 2B6 as the major enzyme involved.

Chemical Research in Toxicology, 2013
Polybrominated diphenyl ethers (PBDEs) were widely used flame retardants that have become persistent environmental pollutants. In the present study, we investigated the in vitro oxidative metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), a major
C. Erratico, A. Szeitz, S. Bandiera
semanticscholar   +1 more source

Metabolism of nitrosoacetoxymethylmethylamine in liver microsomes

Biochemical Pharmacology, 1981
Abstract The carcinogen nitrosoacetoxymethylmethylamine (NAMM)‡ was incubated with mouse liver microsomes. The decomposition rate of NAMM and the formation of methanol were determined. After addition of an NADPH-regenerating system, formaldehyde formation resulting from metabolic degradation of the methyl group of NAMM was measured.
Norbert Frank, Klaus E. Appel, Manfred Wiessler   +2 more
openaire   +3 more sources

Interaction of Cimetidine with Liver Microsomes

Xenobiotica, 1979
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
V. ČSunjić, Slobodan Rendic, R. Toso, Hans-Heinrich Ruf, F. Kajfež   +4 more
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Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

Journal of Pharmacy and Science, 2011
Cytochrome P450 (CYP) proteins are involved in the biological oxidation and reduction of xenobiotics, affecting the pharmacological efficiency of drugs.
H. Kawakami, S. Ohtsuki, J. Kamiie, Takashi Suzuki, T. Abe, T. Terasaki   +5 more
semanticscholar   +1 more source

Pigments of rat liver microsomes

Archives of Biochemistry and Biophysics, 1958
Abstract The total hemin content of washed rat liver microsomes is 2.15 times the cytochrome b5 content, only a small part being due to bound hemoglobin. The content of flavine is 4 5 that of cytochrome b5. The flavine probably does not contribute to the DPNH reduced difference spectrum.
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