Results 121 to 130 of about 81,174 (219)

A strategy for liver selective NRF2 induction via cytochrome P450-activated prodrugs with low activity in hypoxia. [PDF]

J Biol Chem
Ng MY, Hagen T.
europepmc   +1 more source

Identification of human metabolites of fast skeletal troponin activators Tirasemtiv and Reldesemtiv for doping control purposes

Drug Testing and Analysis, Volume 17, Issue 6, Page 812-824, June 2025.
The metabolism and urinary elimination of two substances recently classified as prohibited substances in sport was conducted, yielding suitable target analytes for efficient doping controls employing routinely applied chromatographic‐mass spectrometric test methods.
Luisa Euler, Kim Deinert, Felicitas Wagener, Katja Walpurgis, Mario Thevis   +4 more
wiley   +1 more source

Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac. [PDF]

Molecules
Asare E, Emmanuel S, Du T, Xie H, Liang D, Gao S.   +5 more
europepmc   +1 more source

Human phase‐I metabolism of three synthetic cannabinoids bearing a cumyl moiety and a cyclobutyl methyl or norbornyl methyl tail: Cumyl‐CBMEGACLONE, Cumyl‐NBMEGACLONE, and Cumyl‐NBMINACA

Drug Testing and Analysis, Volume 17, Issue 6, Page 882-896, June 2025.
The human phase‐I metabolism of three SCRAs bearing a cumyl moiety and a CBM or NBM tail, based on LC‐qToF‐MS data of authentic urine specimens. Abstract Synthetic cannabinoid receptor agonists (SCRAs) continue to show high prevalence on the new psychoactive substances drug market.
Arianna Giorgetti, Pietro Brunetti, Belal Haschimi, Benedikt Pulver, Jennifer Paola Pascali, Jan Riedel, Volker Auwärter   +6 more
wiley   +1 more source

Identification of a molecular resistor that controls UCP1-independent Ca²⁺ cycling thermogenesis in adipose tissue. [PDF]

Cell Metab
Auger C, Li M, Fujimoto M, Ikeda K, Yook JS, O'Leary TR, Caycedo MPH, Xiaohan C, Oikawa S, Verkerke ARP, Shinoda K, Griffin PR, Inaba K, Stimson RH, Kajimura S.   +14 more
europepmc   +1 more source

Heat Stress Response in Ruditapes Decussatus: Transcriptional Regulation of Key Pathways and Novel SNPs in Antioxidant Genes

Ecology and Evolution, Volume 15, Issue 6, June 2025.
Climate change is known to affect all levels of biology, setting at risk ecological balance. Among other organisms' groups, aquatic inhabitants, and particularly bivalves, are expected to be influenced to a greater extent owing to their inability to move to more mild temperatures.
Dimitrios K. Papadopoulos, Basile Michaelidis, Ioannis A. Giantsis   +2 more
wiley   +1 more source

Regulatory Effects of Betonica macrantha Extract, Known as Mountain Tea, on miRNA Expression and Its Pharmacokinetic Properties

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Betonica macrantha methanol extract exhibited anticancer activity against MDA‐MB‐231 breast cancer cells (IC50: 0.8 mg/mL), upregulating miR‐19, miR‐20a, miR‐126, and miR‐200c. GC–MS and HPLC analyses identified key bioactive compounds, including α‐pinene, caryophyllene, and catechin, which showed favorable pharmacokinetics and target interactions ...
Muhammed Emin Sarı, Emine Incilay Torunoğlu, Zeynep Betül Sarı, Erdi Can Aytar, Abidin Gümrükçüoğlu, Alper Durmaz, Gamze Demirel   +6 more
wiley   +1 more source

Preclinical pharmacokinetics and in vitro ADME properties of PAT-1102: a novel HDAC inhibitor for cancer therapy. [PDF]

J Cancer Res Clin Oncol
Doreswamy CM, Seekallu S, Venkataramaiah SB, Umesh MC, Devi CS.   +4 more
europepmc   +1 more source

The spatial arrangement of esterases in the microsomal membrane [PDF]

, 1975
Gratzl, Manfred, Nastainczyk, W., Schwab, D.   +2 more
core   +1 more source

Exploring the Healing Potential of Aqueous Extract of Baccaurea ramiflora Leaves in Inflammation: A Cytokine and Prostaglandin Modulator

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This study demonstrates that the aqueous extract of Baccaurea ramiflora leaves (BrLAE) possesses significant antioxidant and anti‐inflammatory properties. BrLAE treatment effectively reduced CFA‐induced paw edema, improved hematological and biochemical parameters, and downregulated pro‐inflammatory gene expression in Wistar rats.
Muhammad Nasir Hayat Malik, Md. Mahedi Hassan Tusher, Begum Rokeya, Sidra Javaid, Saud O. Alshammari, Amr S. Abouzied, Qamar A. Alshammari, Abdulkarim Alshammari, Maryam Zaib, Hafiz Muhammad Bilal, Muhammad Atif, Gideon F. B. Solre   +11 more
wiley   +1 more source