Results 141 to 150 of about 81,174 (219)

Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data. [PDF]

Pharmaceutics
Zhu X, Kong W, Wang Z, Liu X, Liu L.
europepmc   +1 more source

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies. [PDF]

Front Pharmacol
Gu J, Zhang H, Wang M, Zhou Y, Deng Z, Shi R.   +5 more
europepmc   +1 more source

Induction of Peroxisomal β‐Oxidation as a Critical Mechanism for Ethanol‐Induced Hepatic Triglyceride Accumulation

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
Prolonged fasting and fibrate treatment induce peroxisomal β‐oxidation and lead to excessive generation of hydrogen peroxide, which stimulates ethanol metabolism and significantly increases the formation of acetaldehyde; further oxidation of acetaldehyde into acetate remarkably elevates the mitochondrial ratio of NADH/NAD+ and causes feedback ...
Yida Zhang, Wei Zhang, Yicong Li, Haoya Yao, Yaoqing Wang, Xiao Zhang, Jia Zeng   +6 more
wiley   +1 more source

Species Differences in Ezetimibe Glucuronidation. [PDF]

Metabolites
Emmanuel S, Asare EA, Du T, Xie H, Liang D, Gao S.   +5 more
europepmc   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of <i>Mycobacterium tuberculosis</i>. [PDF]

ACS Infect Dis
Green SR, Harrison JR, Thompson S, Murugesan D, Libardo MDJ, Engelhart CA, Meshanni J, Fletcher D, Scullion P, Edwards D, Epemolu O, Mutter N, Shishikura Y, Riley J, Ioerger TR, Roca Guillén JJ, López LG, Read KD, Barry CE, Schnappinger D, Wyatt PG, Boshoff HIM, Cleghorn LAT.   +22 more
europepmc   +1 more source

A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner. [PDF]

Cell Biosci
Sakalauskaite G, Weingartner M, Ebert S, Boot G, Bock T, Birk J, Tsachaki M, Gallon JW, Piscuoglio S, Odermatt A.   +9 more
europepmc   +1 more source

The ontogeny of hepatic cytochrome P450 enzymes in conventional pigs using enzyme activity and proteomics [PDF]

, 2017
Croubels, Siska, Deforce, Dieter, Devreese, Mathias, Gasthuys, Elke, Millecam, Joske, Van Bocxlaer, Jan   +5 more
core   +1 more source

Current insights into pathogenesis and anti‐inflammatory treatment strategies for severe alcohol‐associated hepatitis: focus on neutrophil‐targeted therapies

Hepatology Research, Volume 55, Issue 6, Page 785-794, June 2025.
Abstract Alcohol‐associated hepatitis (AH) is the leading cause of liver‐related mortality, with severe alcohol‐associated hepatitis (SAH) showing a short‐term mortality rate of 20%–50% even in developed countries. Corticosteroids are the only evidence‐based pharmacologic treatment, but their efficacy is limited to short‐term survival, with 30%–40% of ...
Ryosuke Kasuga, Po‐Sung Chu, Takanori Kanai, Nobuhiro Nakamoto   +3 more
wiley   +1 more source