Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305
Rapid Communications in Mass Spectrometry, Volume 39, Issue 22, 30 November 2025.ABSTRACT Rationale 2‐Chloro‐4‐[[(1R,2R)‐2‐hydroxy‐2‐methyl‐cyclopentyl]amino]‐3‐methyl‐benzonitrile (LY305) is a transdermal selective androgen receptor modulator (SARM) that has been under development as a potential therapeutic for conditions involving muscle wasting, osteoporosis, or hypogonadism.
Giorgi Kobidze +4 more
wiley +1 more source
A Hemochromogen Component of Liver Microsomes
, 1952 Cornelius F. Strittmatter, Eric G. Ball
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Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism
International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello +7 more
wiley +1 more source
Stimulation and solubilization of the sodium ion-activated adenosine triphosphatase of cerebral microsomes by surface-active agents, especially polyoxyethylene ethers: actions of phospholipases and a neuraminidase [PDF]
, 1964 PD Swanson, HF Bradford, H. McIlwain
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Beyond Hepatitis: A Rare Case of Multisystem Langerhans Cell Histiocytosis in a Child
Clinical Case Reports, Volume 13, Issue 11, November 2025.ABSTRACT Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder involving abnormal proliferation of dendritic cells, with clinical presentations ranging from isolated lesions to life‐threatening multisystem involvement. This case report describes a 26‐month‐old girl who presented with progressive jaundice, fever, hepatomegaly, pruritic scalp
Dilip Neupane +4 more
wiley +1 more source
Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes [PDF]
, 2019 Bloom, Adam Joseph +2 more
core +2 more sources
The lipid composition of rat-liver mitochondria, fluffy layer and microsomes [PDF]
, 1962 GS Getz +4 more
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British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park +11 more
wiley +1 more source
Inhibition of rat microsomal lipid peroxidation by the oral administration of D002
Brazilian Journal of Medical and Biological Research, 2000 The effect of D002, a defined mixture of higher primary alcohols purified from bee wax, on in vivo and in vitro lipid peroxidation was studied. The extent of lipid peroxidation was measured on the basis of the levels of thiobarbituric acid reactive ...
Menéndez R. +4 more
doaj
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract INTRODUCTION Type 2 diabetes mellitus (T2DM) is a risk factor for dementia and cerebral small vessel disease, but there remains a need to identify targetable molecular pathways involved in the underlying pathophysiology. METHODS In participants with Alzheimer's disease, related dementias, or cerebrovascular diseases, we assessed associations ...
Si Won Ryoo +22 more
wiley +1 more source