Metabolism of polycyclic compounds. 26. The hydroxylation of some aromatic hydrocarbons by the ascorbic acid model hydroxylating system and by rat-liver microsomes [PDF]
, 1964 E. Boyland, Masayuki Kimura, Peter Sims
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In Vitro Evaluation of the Safety and Antineoplastic Effects in Gastrointestinal Tumors of Nanostructured Lipid Carriers Loaded with Berberine. [PDF]
PharmaceuticsStefanova D +10 more
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DIFFERENCES IN THE OXIDATIVE METABOLISM OF DRUGS BY LIVER MICROSOMES
, 1969 Ryuichi Kato +2 more
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Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
Advanced Science, Volume 12, Issue 14, April 10, 2025.A new series of highly potent dipeptidic phosphonates targeting the Pseudomonas aeruginosa protease LasB shows promising in vitro effects, favorable pharmacokinetics, good tolerability, and in vivo efficacy, highlighting their potential as a treatment for Pseudomonas keratitis when combined with meropenem. Abstract The ubiquitous opportunistic pathogen
Alexander F. Kiefer +22 more
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A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates. [PDF]
Membranes (Basel)Younus I, Ford RC, Prince SM.
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THE SOLUBILIZATION OF MICROSOMAL ANTIBODY ACTIVITY BY THE SPECIFIC INTERACTION BETWEEN THE CRYSTALLIZABLE FRACTION OF γ-GLOBULIN AND LYMPH-NODE MICROSOMES [PDF]
, 1961 Milton Kern +2 more
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Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD
Advanced Science, Volume 12, Issue 15, April 17, 2025.A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang +10 more
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Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes. [PDF]
Nat Struct Mol BiolPyle E, Miller EA, Zanetti G.
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Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study presents carnosic acid (CA), an active ingredient of Rosmarinus officinalis L., dramatically ameliorates Trex1 deficiency‐mediated and STING‐dependent systemic inflammatory diseases by targeting STING C‐terminal tail (CTT) to disrupt STING activity.
Wenqing Mu +13 more
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