Results 271 to 280 of about 129,619 (377)

EFFECTS OF SONICATION AND OTHER AGENTS ON THE ACTIONS OF MUSCLE MICROSOMES

, 1964
Hideo Takashina, Minoru Kasuya
openalex   +2 more sources

Primary versus secondary recurrent pregnancy losses: Clinical findings and live birth rate after comprehensive work‐up and personalized management

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 4, Page 697-706, April 2025.
Recurrent pregnancy loss (RPL) is a heterogeneous multifactorial syndrome. A customized management can lead to a good pregnancy outcome in more than a half of cases. Age <40 and AMH >1 ng/mL are the major positive predictors of live birth rate in RPL women.
Chiara Tersigni, Marianna Onori, Giuliana Beneduce, Fabio Sannino, Rita Franco, Andrea Busnelli, Chiara Granieri, Domenico Milardi, Alfredo Pontecorvi, Antonio Lanzone, Giovanni Scambia, Nicoletta Di Simone   +11 more
wiley   +1 more source

Interindividual variability in CYP3A-mediated venetoclax metabolism in vitro and in vivo in patients with chronic lymphocytic leukemia. [PDF]

Clin Transl Sci
Lee J, Beers JL, Cheng I, Truong V, Brown Z, Muluneh B, Coombs CC, Jackson KD.   +7 more
europepmc   +1 more source

Physiologically‐based pharmacokinetic modelling of long‐acting injectable cabotegravir and rilpivirine in pregnancy

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 989-1002, April 2025.
Aims Long‐acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use in pregnancy are limited. Physiologically‐based pharmacokinetic (PBPK) modelling was used to simulate the approved dosing regimens in pregnancy and explore if Ctrough was maintained above cabotegravir and rilpivirine target ...
Shakir Atoyebi, Fazila Bunglawala, Nicolas Cottura, Sandra Grañana‐Castillo, Maiara Camotti Montanha, Adeniyi Olagunju, Marco Siccardi, Catriona Waitt   +7 more
wiley   +1 more source

Preclinical metabolism and metabolic drug-drug interaction profile of pedunculoside and rotundic acid. [PDF]

Clin Transl Sci
Wu L, Dong L, Zhou Z, Wang X, Lin Y, Shi X, Wang P, Xu S, Fang Z.   +8 more
europepmc   +1 more source

AI‐Driven Applications in Clinical Pharmacology and Translational Science: Insights From the ASCPT 2024 AI Preconference

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Artificial intelligence (AI) is driving innovation in clinical pharmacology and translational science with tools to advance drug development, clinical trials, and patient care. This review summarizes the key takeaways from the AI preconference at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2024 Annual Meeting in ...
Mohamed H. Shahin, Prashant Desai, Nadia Terranova, Yuanfang Guan, Tomáš Helikar, Sebastian Lobentanzer, Qi Liu, James Lu, Subha Madhavan, Gary Mo, Flora T. Musuamba, Jagdeep T. Podichetty, Jie Shen, Lei Xie, Mathew Wiens, Cynthia J. Musante   +15 more
wiley   +1 more source

The effect of deuterated PLK1 inhibitor on its safety and efficacy <i>in vivo</i>. [PDF]

Front Oncol
Zhang T, Deng X, Jin H, Peng Z, Hsueh YC, Zhang C, Niu G, Yang J.   +7 more
europepmc   +1 more source

Inhibitors of Protein Synthesis in Rat Liver Microsome Fractions

, 1967
Oscar A. Scornik, Mahlon B. Hoagland, Lorraine C. Pfefferkorn, Elizabeth Bishop   +3 more
openalex   +1 more source

Tspo Depletion Exacerbates Steatosis Through Fatty Acid Uptake

Journal of Cellular and Molecular Medicine, Volume 29, Issue 7, April 2025.
ABSTRACT Previous studies demonstrated that Tspo loss causes simple steatosis (SS) in hepatocytes in vitro. However, its effect on SS in vivo remains unclear. In this study, we hypothesise that Tspo loss promotes early‐stage MASLD. WT and Tspo KO rats were fed a Gubra Amylin NASH (GAN) diet for 8 weeks to induce SS.
Yuchang Li, Liting Chen, Chantal Sottas, Nrupa Dinesh Patel, Mahima Chandrakant Raul, Vassilios Papadopoulos   +5 more
wiley   +1 more source

In Vitro Metabolism and p53 Activation of Genotoxic Chemicals: Abiotic CYP Enzyme vs Liver Microsomes. [PDF]

Chem Res Toxicol
Henneberger L, Huchthausen J, Braasch J, König M, Escher BI.   +4 more
europepmc   +1 more source