Results 31 to 40 of about 1,205,418 (341)

The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules

eLife, 2022
Cells increase microtubule dynamics to make large rearrangements to their microtubule cytoskeleton during cell division. Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to ...
Thomas S McAlear, Susanne Bechstedt
doaj   +1 more source

New Insights Into Functions of IQ67-Domain Proteins

Frontiers in Plant Science, 2021
IQ67-domain (IQD) proteins, first identified in Arabidopsis and rice, are plant-specific calmodulin-binding proteins containing highly conserved motifs.
Chunyue Guo, Jun Zhou, Jun Zhou, Dengwen Li   +3 more
doaj   +1 more source

Biomolecular condensation of the microtubule-associated protein tau [PDF]

Seminars in Cell & Developmental Biology, 2020
Cells contain multiple compartments dedicated to the regulation and control of biochemical reactions. Cellular compartments that are not surrounded by membranes can rapidly form and dissolve in response to changes in the cellular environment. The physicochemical processes that underlie the formation of non-membrane-bound compartments in vivo are ...
Susanne Wegmann, Markus Zweckstetter, Markus Zweckstetter, Markus Zweckstetter, Tina Ukmar-Godec   +4 more
openaire   +5 more sources

Manipulation and quantification of microtubule lattice integrity

Biology Open, 2017
Microtubules are structural polymers that participate in a wide range of cellular functions. The addition and loss of tubulin subunits allows the microtubule to grow and shorten, as well as to develop and repair defects and gaps in its cylindrical ...
Taylor A. Reid, Courtney Coombes, Melissa K. Gardner   +2 more
doaj   +1 more source

GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. [PDF]

PLoS ONE, 2012
The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate ...
Massimilano Scolz, Per O Widlund, Silvano Piazza, Debora Rosa Bublik, Simone Reber, Leticia Y Peche, Yari Ciani, Nina Hubner, Mayumi Isokane, Martin Monte, Jan Ellenberg, Anthony A Hyman, Claudio Schneider, Alexander W Bird   +13 more
doaj   +1 more source

Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function [PDF]

European Journal of Biochemistry, 1992
Mitogen‐activated protein kinase (MAPK), a serine/threonine‐specific protein kinase which is generally activated by stimulation with various growth factors and phorbol esters, utilizes microtubule‐associated protein (MAP) 2 as a good substrate in vitro.
Hiromu Murofushi, Kunihiro Ohta, Hikoichi Sakai, Yukiko Gotoh, Eisuke Nishida, Akiko Mori, Minako Hoshi   +6 more
openaire   +2 more sources

Xenopus meiotic microtubule-associated interactome. [PDF]

PLoS ONE, 2010
In metazoan oocytes the assembly of a microtubule-based spindle depends on the activity of a large number of accessory non-tubulin proteins, many of which remain unknown. In this work we isolated the microtubule-bound proteins from Xenopus eggs.
Vincent Gache, Patrice Waridel, Christof Winter, Aurelie Juhem, Michael Schroeder, Andrej Shevchenko, Andrei V Popov   +6 more
doaj   +1 more source

Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins

Molecular Brain, 2015
BackgroundYoung neurons in the developing brain establish a polarized morphology for proper migration. The PIWI family of piRNA processing proteins are considered to be restrictively expressed in germline tissues and several types of cancer cells.
Ping-ping Zhao, Mao-jin Yao, Si-yuan Chang, Lan-Tao Gou, Mo-Fang Liu, Z. Qiu, Xiao-Bing Yuan   +6 more
semanticscholar   +1 more source

Microtubule-associated Proteins 1 (MAP1) Promote Human Immunodeficiency Virus Type I (HIV-1) Intracytoplasmic Routing to the Nucleus

Journal of Biological Chemistry, 2014
Background: During infection, HIV uses the host cytoskeleton to traffic across the cytoplasm to the nucleus where it integrates its genome. Results: Microtubule-associated proteins (MAP1A and MAP1S) promote HIV trafficking to the nucleus.
Juliette Fernandez, D. Portilho, A. Danckaert, S. Munier, A. Becker, P. Roux, Anaba Zambo, S. Shorte, Y. Jacob, P. Vidalain, P. Charneau, F. Clavel, N. Arhel   +12 more
semanticscholar   +1 more source

Phase separation of the microtubule-associated protein tau

Essays in Biochemistry, 2022
Abstract The aggregation and misfolding of the neuronal microtubule-associated protein tau is closely linked to the pathology of Alzheimer’s disease and several other neurodegenerative diseases. Recent evidence suggest that tau undergoes liquid–liquid phase separation in vitro and forms or associates with membrane-less organelles in ...
Pijush Chakraborty, Markus Zweckstetter
openaire   +5 more sources