Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. [PDF]
, 2015 Casein kinase 1δ (CK1δ) family members associate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and targets have yet to be identified.
Agard, David A +10 more
core +1 more source
Xenopus meiotic microtubule-associated interactome. [PDF]
PLoS ONE, 2010 In metazoan oocytes the assembly of a microtubule-based spindle depends on the activity of a large number of accessory non-tubulin proteins, many of which remain unknown. In this work we isolated the microtubule-bound proteins from Xenopus eggs.
Vincent Gache +6 more
doaj +1 more source
Beyond uniformity: Exploring the heterogeneous and dynamic nature of the microtubule lattice
European Journal of Cell Biology, 2023 A fair amount of research on microtubules since their discovery in 1963 has focused on their dynamic tips. In contrast, the microtubule lattice was long believed to be highly regular and static, and consequently received far less attention.
Mariana Romeiro Motta +2 more
doaj +1 more source
Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
core +1 more source
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. [PDF]
PLoS ONE, 2012 The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate ...
Massimilano Scolz +13 more
doaj +1 more source
Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. [PDF]
, 2016 The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
CHISHOLM, Andrew, Tang, Ngang
core +2 more sources
Nuclear-localized subtype of end-binding 1 protein regulates spindle organization in Arabidopsis [PDF]
, 2010 End-binding 1 (EB1) proteins are evolutionarily conserved plus-end-tracking proteins that localize to growing microtubule plus ends where they regulate microtubule dynamics and interactions with intracellular targets.
Abe, Tatsuya +5 more
core +2 more sources
Microtubule-associated protein 1B [PDF]
The Journal of Cell Biology, 2001 Myelin-associated glycoprotein (MAG) is expressed in periaxonal membranes of myelinating glia where it is believed to function in glia–axon interactions by binding to a component of the axolemma. Experiments involving Western blot overlay and coimmunoprecipitation demonstrated that MAG binds to a phosphorylated neuronal isoform of microtubule ...
Rachelle Franzen +5 more
openaire +1 more source
Genes of ancient microtubule-stabilizing proteins traveled through pre-Cambrian Echinoidea to advanced life forms of dry land and ended up in the human genome as the fusion oncogenes-oncoproteins eml1/EML1-abl/ABL, and eml4/EML4-alk/ALK [PDF]
Invertebrate Survival Journal, 2016 The genes eml1/4 of the Echinodermata microtubule-stabilizing gene product-like 1/4 proteins EML1/4 of the sea cucumbers (Holothuroidea) traveled through the evolutionary scale up to the human genome.
JG Sinkovics
doaj +2 more sources
Actin Cytoskeleton and Golgi Involvement in Barley stripe mosaic virus Movement and Cell Wall Localization of Triple Gene Block Proteins. [PDF]
, 2013 Barley stripe mosaic virus (BSMV) induces massive actin filament thickening at the infection front of infected Nicotiana benthamiana leaves. To determine the mechanisms leading to actin remodeling, fluorescent protein fusions of the BSMV triple gene ...
Bae, Hanhong +10 more
core +2 more sources