Results 101 to 110 of about 199,967 (323)

Stabilization of microtubules due to microtubule-associated proteins: A simple model [PDF]

arXiv, 2003
A theoretical model of stabilization of a microtubule assembly due to microtubule-associated-proteins(MAP) is presented. MAPs are assumed to bind to the microtubule filaments, thus preventing their disintegration following hydrolysis and enhancing further polymerization.
arxiv  

A Stochastic Multiscale Model that Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases [PDF]

, 2015
The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two axonal cytoskeletal polymers microtubules and neurofilaments align longitudinally in axons and are interspersed in axonal cross-sections.
arxiv   +1 more source

Synthetic Active Liquid Crystals Powered by Acoustic Waves

Advanced Materials, EarlyView.
A fully synthetic active liquid crystal, energized by an acoustic field, is presented. This system exhibits active nematic behavior, tunable topological defect dynamics, and persistent hydrodynamic vortices at high activity levels. The material maintains stable properties while enabling precise activity control in a wide range.
Andrey Sokolov, Jaideep Katuri, Juan J. de Pablo, Alexey Snezhko   +3 more
wiley   +1 more source

Non-centrosomal TPX2-dependent regulation of the Aurora A kinase: functional implications for healthy and pathological cell division

Frontiers in Oncology, 2016
Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Georgina eGarrido, Georgina eGarrido, Georgina eGarrido   +6 more
doaj   +1 more source

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface

Frontiers in Cell and Developmental Biology, 2020
Successful mitotic cell division is critically dependent on the formation of correct attachments between chromosomes and spindle microtubules. Microtubule attachments are mediated by kinetochores, which are large proteinaceous structures assembled on ...
Robert T. Wimbish, Jennifer G. DeLuca
doaj   +1 more source

Optical Nanoscopy for Elucidating Nano–Bio Interactions: A One Health Perspective

Advanced Optical Materials, EarlyView.
The review comprehensively summarizes the application of far‐field fluorescence nanoscopy for the characterization of nanomaterial interactions with biological systems at the single‐particle and molecular scale, with an accent on their impact on human and ecosystem health.
Elisa De Luca, Chiara Coricciati, Marcella Trombetta, Giuseppe Gigli, Pamela Mozetic, Alberto Rainer   +5 more
wiley   +1 more source

The Nervous System Cytoskeleton under Oxidative Stress

Diseases, 2013
Oxidative stress is a key mechanism causing protein aggregation, cell death and neurodegeneration in the nervous system. The neuronal cytoskeleton, that is, microtubules, actin filaments and neurofilaments, plays a key role in defending the nervous ...
John Gardiner, Robyn Overall, Jan Marc
doaj   +1 more source

Picomolar Detection of Tau Protein Using 1D Photonic Crystal Biochips for Alzheimer's Disease Diagnosis

Advanced Sensor Research, EarlyView.
Elevated levels of Tau in cerebrospinal fluids or other body fluids are associated with the progression of Alzheimer's disease. An optical technique, based on a dual label‐free and fluorescence operation mode, is developed to detect Tau protein in both standard running buffer and cerebrospinal fluid.
Alberto Sinibaldi, Francesco Chiavaioli, Agostino Occhicone, Norbert Danz, Peter Munzert, Francesco Baldini, Ambra Giannetti, Francesco Michelotti   +7 more
wiley   +1 more source

Optical Microfiber Biomedical Sensors: Classification, Applications, and Future Perspectives

Advanced Sensor Research, EarlyView.
This review delves deeply into the various types of optical microfiber biosensors, grounded firmly in their fundamental principles, and underscores their indispensable roles in pushing forward biomedical advancements. It examines the latest advancements, challenges faced by these biosensors in practical applications, future directions, breakthroughs ...
Lili Liang, Fei Xie, Li Jin, Bowen Yang, Li‐Peng Sun, Bai‐Ou Guan   +5 more
wiley   +1 more source

Hippocampal hyperexcitability is modulated by microtubule-active agent: evidence from in vivo and in vitro epilepsy models in the rat.

Frontiers in Cellular Neuroscience, 2016
The involvement of microtubule dynamics on bioelectric activity of neurons and neurotransmission represents a fascinating target of research in the context of neural excitability.
Fabio eCarletti, Pierangelo eSardo, Giuditta eGambino, Xin-An eLiu, Giuseppe eFerraro, Valerio eRizzo, Valerio eRizzo   +6 more
doaj   +1 more source