Results 101 to 110 of about 407,687 (331)

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

The Novel Nature Microtubule Inhibitor Ivalin Induces G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells In Vitro

Medicina, 2019
Background and Objectives: Microtubules are an attractive target for cancer chemotherapy. Previously, we reported that Ivalin exhibited excellent anti-migration and anti-invasion activities in human breast cancer cells.
Fangyuan Liu, Shiqi Lin, Caiyun Zhang, Jiahui Ma, Zhuo Han, Fujuan Jia, Weidong Xie, Xia Li   +7 more
doaj   +1 more source

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

Advanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam, Rabia Ali, Lordean Gustinvil, Matthew J. Rosenwasser, Iain E. Dunlop, Derfogail Delcassian   +5 more
wiley   +1 more source

Model of ionic currents through microtubule nanopores and the lumen

, 2009
It has been suggested that microtubules and other cytoskeletal filaments may act as electrical transmission lines. An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its ...
A. M. Gomez, Avner Priel, D. K. Meyer, Eric Carpenter, Holly Freedman, J. A. Tuszynski, J. A. Tuszynski, Jack A. Tuszynski, Sergei Y. Noskov, V. A. Maltsev, Vahid Rezania   +10 more
core   +1 more source

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

, 2023
Danielle B. Buglak, Pauline Bougaran, Molly R. Kulikauskas, Ziqing Liu, Elizabeth Monaghan-Benson, A. Gold, Allison Marvin, Andrew Burciu, Natalie T. Tanke, Morgan Oatley, Shea Ricketts, Karina Kinghorn, Bryan N Johnson, Celia E. Shiau, Stephen L. Rogers, Christophe Guilluy, Victoria L. Bautch   +16 more
openalex   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction

New Journal of Physics, 2017
The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from the properties of the network’s constituent motor proteins and ...
Peter J Foster, Wen Yan, Sebastian Fürthauer, Michael J Shelley, Daniel J Needleman   +4 more
doaj   +1 more source

The distribution of cytoplasmic microtubules throughout the cell cycle of the centric diatom Stephanopyxis turris: their role in nuclear migration and positioning the mitotic spindle during cytokinesis. [PDF]

, 1986
The cell cycle of the marine centric diatom Stephanopyxis turris consists of a series of spatially and temporally well-ordered events. We have used immunofluorescence microscopy to examine the role of cytoplasmic microtubules in these events.
Cande, WZ, McDonald, KL, Wordeman, L
core  

A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes

, 2009
Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in the ...
A. Quarteroni, Jack A. Tuszyński, N. M. Rusan, P. M. Bayley, Peter Hinow, R. F. Gildersleeve, Vahid Rezania   +6 more
core   +1 more source