Results 81 to 90 of about 289,777 (310)

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

eLife, 2020
When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles.
Peter Jan Hooikaas, Hugo GJ Damstra, Oane J Gros, Wilhelmina E van Riel, Maud Martin, Yesper TH Smits, Jorg van Loosdregt, Lukas C Kapitein, Florian Berger, Anna Akhmanova   +9 more
doaj   +1 more source

Formins and microtubules

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their ...
Bartolini, F., Gundersen, G.G.
openaire   +2 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Kank Is an EB1 Interacting Protein that Localises to Muscle-Tendon Attachment Sites in Drosophila [PDF]

, 2014
Little is known about how microtubules are regulated in different cell types during development. EB1 plays a central role in the regulation of microtubule plus ends.
Hiroyuki Ohkura (90476), Sara M R Clohisey, Clohisey Sara M. R., Ohkura, Hiroyuki, Nikola S. Dzhindzhev (207024), Hiroyuki Ohkura, Dzhindzhev Nikola S., Clohisey, Sara M R, Nikola S Dzhindzhev, Dzhindzhev, Nikola S, Ohkura Hiroyuki, Sara M. R. Clohisey (627652)   +11 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Cryo-EM structure of VASH1-SVBP bound to microtubules

eLife, 2020
The dynamic tyrosination-detyrosination cycle of α-tubulin regulates microtubule functions. Perturbation of this cycle impairs mitosis, neural physiology, and cardiomyocyte contraction.
Faxiang Li, Yang Li, Xuecheng Ye, Haishan Gao, Zhubing Shi, Xuelian Luo, Luke M Rice, Hongtao Yu   +7 more
doaj   +1 more source

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration [PDF]

, 2015
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo.
Stramer, Brian M., Parsons, Maddy; id_orcid, Frame, Margaret, Bryan Serrels, Serrels, B, Parsons, M., Asier Jayo, Goult, B. T., Jayo, A., Zanet, J., Villari, G., Villari, G, Fitch, B., Serrels, Bryan, Stramer, BM, Fitch, Briana, Goult, Benjamin T., Frame, M., Jennifer Zanet, Frame, M, Jayo, Asier, Goult, Benjamin T, Briana Fitch, Brian M. Stramer, Margaret Frame, Fitch, B, Stramer, B. M., Jayo, A, Zanet, Jennifer, Serrels, B., Maddy Parsons, Parsons, M, Giulia Villari, Zanet, J, Benjamin T. Goult, Villari, Giulia, Stramer, Brian M, Parsons, Maddy   +37 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

eLife, 2020
Intracellular transport relies on multiple kinesins, but it is poorly understood which kinesins are present on particular cargos, what their contributions are and whether they act simultaneously on the same cargo.
Andrea Serra-Marques, Maud Martin, Eugene A Katrukha, Ilya Grigoriev, Cathelijn AE Peeters, Qingyang Liu, Peter Jan Hooikaas, Yao Yao, Veronika Solianova, Ihor Smal, Lotte B Pedersen, Erik Meijering, Lukas C Kapitein, Anna Akhmanova   +13 more
doaj   +1 more source

Vibrations in Microtubules [PDF]

Journal of Biological Physics, 1997
Vibrations in microtubules and actin filaments are analysed using amethod similar to that employed for description of lattice vibrationsin solid state physics. The derived dispersion relations show thatvibrations in microtubules can have optical and acoustical branches.The highest frequency of vibrations in microtubules and in actinfilaments is of the ...
J, Pokorný, F, Jelínek, V, Trkal, I, Lamprecht, R, Hölzel   +4 more
openaire   +2 more sources