Results 71 to 80 of about 266,976 (317)
The Arabidopsis Book, 2015 Microtubules (MTs) are highly conserved polar polymers that are key elements of the eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a heterodimer containing one structural GTP and one hydrolysable and exchangeable GTP, is the building block of MTs and is formed by the sequential action of several molecular chaperones ...
openaire +2 more sources
The organization of the microtubule cytoskeleton and its role on nuclear dynamics in the multinucleate hyphae of "Ashbya gossypii" revealed by live cell imaging and electron microscopy [PDF]
, 2009 Nuclear migration is important for normal growth and development of all eukaryotes including filamentous fungi. Among those, Ashbya gossypii, which is evolutionarily related to the budding yeast Saccharomyces cerevisiae, is a particularly attractive ...
Birrer-Lang, Claudia
core +1 more source
Photocontrolling Microtubule Dynamics with Photoswitchable Chemical Reagents
, 2021 Microtubule dynamics can be inhibited with sub-second temporal resolution and cellular-scale spatial resolution, by using precise illuminations to optically pattern where and when photoswitchable microtubule-inhibiting chemical reagents exert their ...
Oliver, Thorn-Seshold, Joyce, Meiring
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
A method for quantitative analysis of cell microtubules based on image analysis
Di-san junyi daxue xuebao, 2019 Objective To develop a method for objective quantitative analysis of microtubule structure based on image processing and analysis of the pixel ratio and particle size.
LAN Xiaodong +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Vibrations in Microtubules [PDF]
Journal of Biological Physics, 1997 Vibrations in microtubules and actin filaments are analysed using amethod similar to that employed for description of lattice vibrationsin solid state physics. The derived dispersion relations show thatvibrations in microtubules can have optical and acoustical branches.The highest frequency of vibrations in microtubules and in actinfilaments is of the ...
J, Pokorný +4 more
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Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane [PDF]
, 2012 Agrin is the major factor mediating the neuronal regulation of postsynaptic structures at the vertebrate neuromuscular junction, but the details of how it orchestrates this unique three-dimensional structure remain unknown.
Jeffrey van Haren +45 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells
eLife, 2020 When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles.
Peter Jan Hooikaas +9 more
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