Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples
Advanced Science, EarlyView.This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen +11 more
wiley +1 more source
Quantum Brain Dynamics: Optical and Acoustic Super-Radiance via a Microtubule
FoundationsWe aim to derive a super-radiance solution of coherent light and sound waves involving water degrees of freedom in the environment of a microtubule. We introduce a Lagrangian density functional of quantum electrodynamics with non-relativistic charged ...
Akihiro Nishiyama +2 more
doaj +1 more source
XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
Advanced Science, EarlyView.Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan +13 more
wiley +1 more source
Involvement of microtubule and microfilament system in the GnRH‐induced release of gonadotropins by rat anterior pituitary cells in culture [PDF]
, 1979 Ashok Khar, Maciej Radek, M Jutisz
openalex +1 more source
Advanced Science, EarlyView.The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng +5 more
wiley +1 more source
Competitive inhibition of colchicine binding to tubulin by microtubule-associated proteins.
, 1979 J. Núñez +3 more
openalex +2 more sources
The growth speed of microtubules with XMAP215-coated beads coupled to their ends is increased by tensile force [PDF]
, 2013 Anastasiya Trushko +2 more
openalex +1 more source
Microtubule pivoting enables mitotic spindle assembly in S. cerevisiae [PDF]
, 2021 Kimberly K. Fong +2 more
openalex +1 more source
Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance
Advanced Science, EarlyView.Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao +5 more
wiley +1 more source