Interplay Between the Cytoskeleton and DNA Damage Response in Cancer Progression. [PDF]
Halim CE, Deng S, Crasta KC, Yap CT.
europepmc +1 more source
Microtubule flexibility, microtubule-based nucleation and ROP pattern co-alignment enhance protoxylem microtubule patterning. [PDF]
Jacobs B+4 more
europepmc +1 more source
Interactions of a photoaffinity analog of GTP with the proteins of microtubules.
Robert L. Geahlen, Boyd E. Haley
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HN1 expression contributes to mitotic fidelity through Aurora A‐PLK1‐Eg5 axis
Abstract Hematological and neurological expressed 1 (HN1) is homolog of Jupiter protein from Drosophila melanogaster where it functions as a microtubule‐associated protein. However, in mammalian cells, HN1 is associated partially with y‐tubulin in centrosomes, Stathmin for stabilizing microtubules, and Cdh1 for regulating Cyclin B1 for cell cycle ...
Gülseren Özduman+3 more
wiley +1 more source
Small-Molecule Mitotic Inhibitors as Anticancer Agents: Discovery, Classification, Mechanisms of Action, and Clinical Trials. [PDF]
Salinas Y, Chauhan SC, Bandyopadhyay D.
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Abstract Tristetraprolin (TTP) is an RNA‐binding protein that negatively regulates its target mRNAs and has been shown to inhibit tumor progression and invasion. Tumor invasion requires precise regulation of cytoskeletal components, and dysregulation of cytoskeleton‐associated genes can significantly alter cell motility and invasive capability. Several
Anastasiia Hubiernatorova+5 more
wiley +1 more source
Tau and MAP6 establish labile and stable domains on microtubules. [PDF]
Kirimtay K+7 more
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The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation
ABSTRACT Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, monociliated cells of the Left–Right Organizer (LRO) exhibit
Saurabh S. Kulkarni+9 more
wiley +1 more source
Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes. [PDF]
Liang RS+7 more
europepmc +1 more source