Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites [PDF]
eLife, 2020 A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. Conserved among both invertebrates and vertebrates, axons contain exclusively ‘plus-end-out’ microtubules while ...
Xing Liang +6 more
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Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity [PDF]
Frontiers in Cellular Neuroscience, 2020 Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and their complexity ...
Oliver R. Wilkes +2 more
doaj +4 more sources
The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress [PDF]
eLife, 2022 Cells encountering stressful situations activate the integrated stress response (ISR) pathway to limit protein synthesis and redirect translation to better cope.
Brian Hurwitz +9 more
doaj +5 more sources
Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers [PDF]
Cells, 2021 Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital microcephaly and other birth defects. Flaviviruses, including ZIKV, reorganize the endoplasmic reticulum (ER) to form a viroplasm, a compartment where virus particles
Rebecca A. Buchwalter +11 more
doaj +5 more sources
A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome [PDF]
eLife, 2019 The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM).
Jérémy Magescas +2 more
doaj +4 more sources
Translation of nervous necrosis virus involves eIF4E but not RPS6 phosphorylation and viral particle assembly in remodeled microtubule-organizing center [PDF]
Virology JournalBackground Nervous necrosis virus (NNV) is a bipartite positive-sense RNA virus that causes piscine viral nervous necrosis disease in larvae and juvenile marine fish.
Vertika Bajpai +11 more
doaj +3 more sources
The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes. [PDF]
PLoS ONE, 2014 The early growth response (Egr) family of zinc finger transcription factors consists of 4 members. During an investigation of Egr factor localization in mouse ovaries, we noted that Egr3 exhibits a subcellular localization that overlaps with the meiotic ...
Hyejin Shin +3 more
doaj +3 more sources
Elevated Estrogen Receptor-α in VHL-Deficient Condition Induces Microtubule Organizing Center Amplification via Disruption of BRCA1/Rad51 Interaction [PDF]
Neoplasia: An International Journal for Oncology Research, 2014 Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step.
Youn-Sang Jung +3 more
doaj +3 more sources
Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope [PDF]
eLife, 2021 Non-centrosomal microtubule-organizing centers (MTOCs) are pivotal for the function of multiple cell types, but the processes initiating their formation are unknown. Here, we find that the transcription factor myogenin is required in murine myoblasts for
Robert Becker +7 more
doaj +2 more sources
End-on microtubule-dynein interactions and pulling-based positioning of microtubule organizing centers [PDF]
Cell Cycle, 2012 During important cellular processes such as centrosome and spindle positioning, dynein at the cortex interacts with dynamic microtubules in an apparent "end-on" fashion. It is well-established that dynein can generate forces by moving laterally along the microtubule lattice, but much less is known about dynein's interaction with dynamic microtubule ...
Liedewij Laan +2 more
openalex +4 more sources