Human oocyte microtubule organizing center: a newly identified driver for meiotic spindle assembly in female oocytes. [PDF]
Life Med, 2023 Dong J, Wu T, Sang Q, Wang L.
europepmc +3 more sources
Analysis of Microtubules and Microtubule-Organizing Center at the Immune Synapse. [PDF]
Methods Mol Biol, 2017 The immune synapse (IS) is a specialized structure that enables cell-cell communication between immune cells. As such, it involves direct cell-to-cell contact. It is sustained by cytoskeletal components that allow the intracellular polarization of different organelles and the surface re-organization of signaling and adhesion receptors.
Blas-Rus N +3 more
europepmc +5 more sources
AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9 [PDF]
eLife, 2020 The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC.
Silvia Vergarajauregui +10 more
doaj +2 more sources
Phosphoproteins are components of mitotic microtubule organizing centers. [PDF]
Proceedings of the National Academy of Sciences, 1984 Protein phosphorylation has been suggested as an important control mechanism for the events leading toward the initiation and completion of mitosis. Using a monoclonal antibody recognizing a class of phosphoproteins abundant in mitotic cells, we demonstrated the localization of a subset of these phosphoproteins to several discrete mitotic structures ...
D. D. Vandré +3 more
openalex +4 more sources
The centriolar satellite protein Cfap53 facilitates formation of the zygotic microtubule organizing center in the zebrafish embryo. [PDF]
Development, 2022 Willekers S +8 more
europepmc +2 more sources
Mobility, Microtubule Nucleation and Structure of Microtubule-organizing Centers in Multinucleated Hyphae ofAshbya gossypii [PDF]
Molecular Biology of the Cell, 2009 We investigated the migration of multiple nuclei in hyphae of the filamentous fungus Ashbya gossypii. Three types of cytoplasmic microtubule (cMT)-dependent nuclear movements were characterized using live cell imaging: short-range oscillations (up to 4.5 μm/min), rotations (up to 180° in 30 s), and long-range nuclear bypassing (up to 9 μm/min).
Claudia Lang +5 more
openalex +5 more sources
Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond [PDF]
Frontiers in Immunology, 2012 Cytoskeletal polarization is crucial for many aspects of immune function, ranging from neutrophil migration to the sampling of gut flora by intestinal dendritic cells.
Morgan eHuse
doaj +2 more sources
The Reduction in Microtubule Arrays Caused by the Dysplasia of the Non-Centrosomal Microtubule-Organizing Center Leads to a Malformed Organ of Corti in the Cx26-Null Mouse. [PDF]
Biomedicines, 2022 Qiu Y, Xu K, Xie L, Chen S, Sun Y.
europepmc +3 more sources
The impact of post-translational modifications and subcellular localization on NLRP3 inflammasome activation: A systematic review [PDF]
Cell Communication and SignalingBackground The NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is crucial for innate immunity. However, its uncontrolled and dysregulated activation may cause various inflammatory and autoimmune disorders.
Shuchi Zhang +6 more
doaj +2 more sources
Cytoskeletal remodeling via CAMSAP3 downregulation drives resistance to osimertinib in NSCLC cells [PDF]
Cell Death and DiseaseOsimertinib, also known as AZD9291, is a highly potent and selective EGFR mutants (including exon 19 deletion, L858R/T790M) inhibitor that significantly inhibits EGFR phosphorylation signaling. However, acquired resistance to osimertinib is inevitable in
Fei Yang +7 more
doaj +2 more sources