Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. [PDF]
, 2016 Centrosomes are major microtubule organizing centers (MTOCs) that play an important role in chromosome segregation during cell division. Centrosomes provide a stable anchor for microtubules, constituting the centers of the spindle poles in mitotic cells,
Chen, Ju +2 more
core +2 more sources
Remote control of microtubule plus-end dynamics and function from the minus-end
eLife, 2019 In eukaryotes, the organization and function of the microtubule cytoskeleton depend on the allocation of different roles to individual microtubules. For example, many asymmetrically dividing cells differentially specify microtubule behavior at old and ...
Xiuzhen Chen +5 more
doaj +1 more source
Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
Communications Biology, 2021 Shortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown ...
Carla M. C. Abreu, Tiago J. Dantas
doaj +1 more source
Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes [PDF]
, 2013 We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation.
Abe, Hiroshi +9 more
core +1 more source
Stathmin Regulates Microtubule Dynamics and Microtubule Organizing Center Polarization in Activated T Cells [PDF]
The Journal of Immunology, 2012 Abstract Polarization of T cells involves reorientation of the microtubule organizing center (MTOC). Because activated ERK is localized at the immunological synapse, we investigated its role by showing that ERK activation is important for MTOC polarization.
Erin L, Filbert +4 more
openaire +2 more sources
Perturbing Microtubule Integrity Blocks AMP-Activated Protein Kinase-Induced Meiotic Resumption in Cultured Mouse Oocytes [PDF]
, 2012 The oocyte meiotic spindle is comprised of microtubules (MT) that bind chromatin and regulate both metaphase plate formation and karyokinesis during meiotic maturation; however, little information is known about their role in meiosis reinitiation.
Downs, Stephen, Ya, Ru
core +2 more sources
Microtubules and Lis-1/NudE/dynein regulate invasive cell-on-cell migration in Drosophila. [PDF]
PLoS ONE, 2012 The environment through which cells migrate in vivo differs considerably from the in vitro environment where cell migration is often studied. In vivo many cells migrate in crowded and complex 3-dimensional tissues and may use other cells as the ...
Nachen Yang +3 more
doaj +1 more source
Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules [PDF]
, 2018 Microtubules (MTs) must be generated from precise locations to form the structural frameworks required for cell shape and function. MTs are nucleated by the γ-tubulin ring complex (γ-TuRC), but it remains unclear how γ-TuRC gets to the right location ...
Aitken +38 more
core +2 more sources
Centrioles without microtubules: a new morphological type of centriole
Biology Open, 2018 The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude.
Rustem Uzbekov +2 more
doaj +1 more source
Alternative Splicing of Pericentrin Contributes to Cell Cycle Control in Cardiomyocytes
Journal of Cardiovascular Development and Disease, 2021 Induction of cardiomyocyte proliferation is a promising option to regenerate the heart. Thus, it is important to elucidate mechanisms that contribute to the cell cycle arrest of mammalian cardiomyocytes.
Jakob Steinfeldt +3 more
doaj +1 more source