The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling
Frontiers in Immunology, 2018 By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-
Charlene Börtlein +6 more
doaj +1 more source
General theory for the mechanics of confined microtubule asters [PDF]
, 2014 In cells, dynamic microtubules organize into asters or spindles to assist positioning of organelles. Two types of forces are suggested to contribute to the positioning process: (i) microtubule-growth based pushing forces ; and (ii) motor protein mediated
Dogterom, Marileen +4 more
core +3 more sources
Paxillin Localizes to the Lymphocyte Microtubule Organizing Center and Associates with the Microtubule Cytoskeleton [PDF]
Journal of Biological Chemistry, 2000 Paxillin is a focal adhesion-associated protein that functions as a multi-domain adapter protein, binding several structural and signaling molecules. alpha-Tubulin was identified as an interacting protein in a two-hybrid screen using the paxillin C-terminal LIM domain as a bait.
Herreros, Lourdes +8 more
openaire +3 more sources
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease. [PDF]
PLoS ONE, 2010 BACKGROUND: Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common form of dementia. The major molecular risk factor for late-onset AD is expression of the epsilon-4 allele of apolipoprotein E (apoE), the major cholesterol ...
Jose F Abisambra +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang +9 more
wiley +1 more source
Cell proliferation, cell shape, and microtubule and cellulose microfibril organization of tobacco BY-2 cells are not altered by exposure to near weightlessness in space [PDF]
, 2009 The microtubule cytoskeleton and the cell wall both play key roles in plant cell growth and division, determining the plant’s final stature. At near weightlessness, tubulin polymerizes into microtubules in vitro, but these microtubules do not self ...
Emons, A.M.C. +4 more
core +4 more sources
Tailored Xenogeneic‐Free Polymer Surface Promotes Dynamic Migration of Intestinal Stem Cells
Advanced Materials, EarlyView.This study introduces a PoLymer‐coated Ultra‐stable Surface (PLUS), a nitrogen plasma‐treated poly(ethyleneglycoldimethacrylate), as a stable xenogeneic‐free platform for intestinal stem cell culture. PLUS enhances cell attachment, supports actin‐driven migration, and retains functionality after 3 years of storage. Promoting cytoskeletal reorganization,
Seonghyeon Park +13 more
wiley +1 more source
The Golgi Apparatus: Morphology and Function with Recent Facts
Bezmiâlem Science, 2019 At the center of the secretory pathway, the Golgi complex ensures correct processing and sorting of cargos towards their final destination sites which are the cytoplasm, plasma membrane, and endosome-lysosome system.
Mukaddes Eşrefoğlu
doaj +1 more source
CRISPR-mediated Tagging with BirA Allows Proximity Labeling in Toxoplasma gondii
Bio-Protocol, 2018 Defining protein interaction networks can provide key insights into how protein complexes govern complex biological problems. Here we define a method for proximity based labeling using permissive biotin ligase to define protein networks in the ...
Shaojun Long, Kevin Brown, L. Sibley
doaj +1 more source