Results 121 to 130 of about 131,190 (318)
Beyond the GTP‐cap: Elucidating the molecular mechanisms of microtubule catastrophe
BioEssays, Volume 45, Issue 1, January 2023., 2023 Microtubule dynamics are essential for myriad cellular processes. The switching between microtubule growth and shrinkage is traditionally explained by the loss of a protective “cap” of GTP‐bound tubulin subunits from the growing microtubule end. New research shows that features beyond the nucleotide content at the growing end impact microtubule ...
Veronica J. Farmer, Marija Zanic
wiley +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source
Microtubule in Azotobacter vinelandii strain O [PDF]
, 1967 L M Pope, Peter Jurtshuk
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Microtubule Organization and Microtubule-Associated Proteins (MAPs)
, 2016 Dendrites have a unique microtubule organization. In vertebrates, dendriticmicrotubules are organized in antiparallel bundles, oriented with their plusends either pointing away or toward the soma. The mixed microtubule arrayscontrol intracellular trafficking and local signaling pathways, and are essential fordendrite development and function.
Tortosa Binacua, E. +2 more
openaire +3 more sources
Advanced Science, EarlyView.A non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate osteoarthritis. This study dynamically “visualizes” the invisible mechanical stimuli of LIPUS on living chondrocytes by fluorescence imaging technology in the form of calcium oscillations, confirming LIPUS maintains cartilage homeostasis by promoting ...
Mengtong Guan +12 more
wiley +1 more source
PROPERTIES OF THE PROTEIN SUBUNIT OF CENTRAL-PAIR AND OUTER-DOUBLET MICROTUBULES OF SEA URCHIN FLAGELLA [PDF]
, 1968 Michael L. Shelanski, Edwin W. Taylor
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DAPK3 is Essential for DBP‐Induced Autophagy of Mouse Leydig Cells
Advanced Science, EarlyView.This study has confirmed that death‐associated protein kinase 3 (DAPK3) is essential for dibutyl phthalate (DBP)‐induced autophagy of mouse Leydig cells, and is regulated by both transcription factor specific protein 2 (Sp2) and parkin RBR E3 ubiquitin‐protein ligase (PRKN), and melatonin can alleviate DBP‐induced autophagy of the cells.
Si Yang +4 more
wiley +1 more source
Basic and Clinical Neuroscience, 2022 Introduction: Information processing in microtubules is an open question that has not been adequately addressed. It was suggested that microtubules could store and process information in the nervous system or even support consciousness.
Abolfazl Alipour +2 more
doaj
Advanced Science, EarlyView.Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu +10 more
wiley +1 more source