Results 171 to 180 of about 131,190 (318)
Cancer, Volume 129, Issue 2, Page 283-295, 15 January 2023., 2023 Abstract Background Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. Methods In a systematic review and meta‐analysis of data gathered from different scientific databases ...
Youwen Zhu +3 more
wiley +1 more source
The mechanism of microtubule assembly in vitro [PDF]
, 1974 Marc W. Kirschner, Robley C. Williams
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Animal Models and Experimental Medicine, EarlyView.Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai +7 more
wiley +1 more source
A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine sponge alkaloid analogues
Drug Development Research, Volume 83, Issue 8, Page 1906-1922, December 2022., 2022 Abstract Here, we describe the synthesis and biologic activity evaluation of 20 novel synthetic marine sponge alkaloid analogues with 2‐amino‐1H‐imidazol (2‐AI) core. Cytotoxicity was tested on murine 4T1 breast cancer, A549 human lung cancer, and HL‐60 human myeloid leukemia cells by the resazurin assay.
Nikolett Gémes +10 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features.
Elvira Immacolata Parrotta +15 more
wiley +1 more source
Nucleotide release from tubulin and nucleoside-5'-diphosphate kinase action in microtubule assembly.
, 1979 Brian Terry, D L Purich
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Advanced NanoBiomed Research, EarlyView.Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cancer cell‐derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for targeted cancer treatment. Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment.
Wei Zhang +4 more
wiley +1 more source
The cytoproct of Paramecium caudatum: Sxstructure and function, microtubules, and fate of food vacuole membranes [PDF]
, 1974 Richard D. Allen, Rainer Wolf
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Angewandte Chemie International Edition, EarlyView.Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach +6 more
wiley +1 more source