Results 171 to 180 of about 249,538 (351)
The mechanism of microtubule assembly in vitro [PDF]
, 1974 Marc W. Kirschner, Robley C. Williams
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Advanced Science, EarlyView.The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu +25 more
wiley +1 more source
Notizen: Cross-Bridges Between Intramacronuclear Microtubules and Inner Nuclear Membrane [PDF]
, 1971 Werner W. Franke
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Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding
Advanced Science, EarlyView.Sevoflurane‐induced neurotoxicity exhibits sex differences, and estrogen can mitigate these effects; however, its protective action appears to be time‐window dependent, which may be related to the competitive binding of estrogen and Tau to ERα. Abstract Sevoflurane‐induced neurotoxicity is age‐dependent, but the role of sex differences is unclear ...
Feixiang Li +8 more
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The cytoproct of Paramecium caudatum: Sxstructure and function, microtubules, and fate of food vacuole membranes [PDF]
, 1974 Richard D. Allen, Rainer Wolf
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Advanced Science, EarlyView.Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang +21 more
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Advanced Science, EarlyView.This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani +12 more
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