Results 221 to 230 of about 249,538 (351)

Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning

, 1977
Robert L. Margolis, Leslie Wilson
openalex   +1 more source

INTRANUCLEAR MICROTUBULE ORGANIZING CENTER IN EARLY PROPHASE NUCLEI OF THE PLASMODIUM OF THE SLIME MOLD, PHYSARUM POLYCEPHALUM [PDF]

, 1973
Kenji Tanaka
openalex   +1 more source

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, EarlyView.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +2 more sources

Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli. [PDF]

Cell Mol Life Sci
Mohammed D, Hamid I, Vanhollebeke B, Martin M.   +3 more
europepmc   +1 more source

Interactions of a photoaffinity analog of GTP with the proteins of microtubules.

, 1977
Robert L. Geahlen, Boyd E. Haley
openalex   +1 more source

Evidence for rapid structural and functional changes of the melanophore microtubule-organizing center upon pigment movements [PDF]

, 1979
Manfred Schliwa, Ursula Euteneuer, Wilhelm Herzog, K. Weber   +3 more
openalex   +1 more source

Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice

Annals of Neurology, EarlyView.
This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije, Sara T. De Palma, Josine E. G. Vaes, Katiuscia Dallaglio, Giorgia Volpi, Diego Ardigò, Sabine van Rijt, Frank van Bel, Manon J. N. L. Benders, Cora H. A. Nijboer   +9 more
wiley   +1 more source

One‐Step Assembly of α‐Aryl‐Substituted DOTAs as Superior and Universal Platforms for Multifunctional Theranostics

Angewandte Chemie, EarlyView.
A one‐step multi‐component synthetic approach is reported to construct α‐aryl‐substituted DOTAs, which required tedious multi‐step synthesis in all previous works. The synthesized α‐aryl‐substituted DOTAs showed improved performance for developing multifunctional theranostics and represent a universal platform for bioconjugation. Abstract α‐Substituted
Pak‐Lun Lam, Yue Wu, Lijia Yao, Hei‐Yui Kai, Ho‐Fai Chau, Qian Zhang, Wanqi Zhou, Jean‐Claude G. Bünzli, Ka‐Leung Wong   +8 more
wiley   +2 more sources

Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions. [PDF]

J Cell Biol
Avilov I, Horokhovskyi Y, Mehta P, Welp L, Jakobi J, Cai M, Orzechowski A, Urlaub H, Liepe J, Lenart P.   +9 more
europepmc   +1 more source