ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith+9 more
wiley +1 more source
Correction: Microtubules and Gαo-signaling modulate the preferential secretion of young insulin secretory granules in islet β cells via independent pathways. [PDF]
Hu R+5 more
europepmc +1 more source
A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture. [PDF]
Pudlowski R+7 more
europepmc +1 more source
TRiC Is a Structural Component of Mammalian Sperm Axonemes
ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Alan Brown+3 more
wiley +1 more source
Control of plasma membrane-associated actin polymerization specifies the pattern of the cell wall in xylem vessels. [PDF]
Kijima ST+9 more
europepmc +1 more source
Interaction of viomycin and aminoglycoside antibiotics with tubulin and microtubules.
Tetsu Akiyama+3 more
openalex +2 more sources
Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley +1 more source
Tubulin tyrosination/detyrosination regulate the affinity and sorting of intraflagellar transport trains on axonemal microtubule doublets. [PDF]
Chhatre A+5 more
europepmc +1 more source