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Microtubule nucleation

Current Opinion in Cell Biology, 2003
Microtubule nucleation is the process in which several tubulin molecules interact to form a microtubule seed. Microtubule nucleation occurs spontaneously in purified tubulin solutions, and molecular intermediates between tubulin dimers and microtubules have been identified.
Didier, Job   +2 more
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Mechanics of microtubules

Journal of Biomechanics, 2010
Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the support structures for extended morphologies, such as axons and cilia. Further, microtubules act as tension rods to pull apart chromosomes during cellular division. Unlike other cytoskeletal filaments (e.g.
Taviare, Hawkins   +3 more
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Microtubules and Microtubule Motors: Mechanisms of Regulation

1996
Microtubule-based motility is precisely regulated, and the targets of regulation may be the motor proteins, the microtubules, or both components of this intricately controlled system. Regulation of microtubule behavior can be mediated by cell cycle-dependent changes in centrosomal microtubule nucleating ability and by cell-specific, microtubule ...
C D, Thaler, L T, Haimo
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Intranuclear Microtubules

Science, 1966
Intranuclear microtubules are a regular feature of spermatocyte meiosis in a crane fly ( Nephrotoma suturalis Loew).
O, Behnke, A, Forer
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Isolation of Microtubules and Microtubule-Associated Proteins

2016
Microtubules are essential cellular structures in plant cells. They are polymerized from tubulin dimers and are regulated by microtubule-associated proteins (MAPs). Here, we describe a protocol for purifying tubulin dimers and MAPs from plant cells.
Takahiro, Hamada, Seiji, Sonobe
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Microtubules and spermatogenesis

Seminars in Cell & Developmental Biology, 2014
Microtubules are dynamic polymers of tubulin subunits that underpin many essential cellular processes, such as cell division and migration. Spermatogenesis is the process by which spermatogenic stem cells undergo mitotic and meiotic division and differentiation to produce streamlined spermatozoa capable of motility and fertilization.
O'Donnell, L., O'Bryan, M.
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Microtubules in the Lens

Archives of Ophthalmology, 1968
Microtubules were regularly demonstrated in lens cells. They were especially abundant in the cortex at the equator where the movement of lens cells is most active. The microtubules may serve to maintain the shape and rigidity of the lens cell at the portion of constant movement.
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Microtubule dynamics

Current Opinion in Cell Biology, 1992
Although compelling evidence has been obtained for heterogeneity in the structure of subunits in microtubules, it has not been possible to prove that this results from the presence of tubulin-GDP and tubulin-GTP in polymers. There are reasons to exclude the existence of even a monolayer of tubulin-GTP subunits at microtubule ends.
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Microtubules and Maps

2005
Microtubules are very dynamic polymers whose assembly and disassembly is determined by whether their heterodimeric tubulin subunits are in a straight or curved conformation. Curvature is introduced by bending at the interfaces between monomers. Assembly and disassembly are primarily controlled by the hydrolysis of guanosine triphosphate (GTP) in a site
Linda A, Amos, Daniel, Schlieper
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Ordering microtubules

BioEssays, 1997
AbstractHow do cells order their cytoplasm? While microtubule organizing centers have long been considered essential to conferring order by virtue of their microtubule nucleating activity, attention has currently refocused on the role that microtubule motors play in organizing microtubules.
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