Results 91 to 100 of about 131,858 (288)

DNA-PKcs Phosphorylates Cofilin2 to Induce Endothelial Dysfunction and Microcirculatory Disorder in Endotoxemic Cardiomyopathy

Research
The presence of endotoxemia is strongly linked to the development of endothelial dysfunction and disruption of myocardial microvascular reactivity. These factors play a crucial role in the progression of endotoxemic cardiomyopathy.
Yingzhen Du, Pingjun Zhu, Yukun Li, Jiachi Yu, Tian Xia, Xing Chang, Hang Zhu, Ruibing Li, Qingyong He   +8 more
doaj   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Skin microvascular reactivity in children and adolescents with type 1 diabetes in relation to levels of physical activity and aerobic fitness

, 2008
No studies to date have evaluated the relationship between exercise and microvascular function in youth with type 1 diabetes mellitus (T1DM). Twenty-nine complication free children and adolescents with T1DM were assessed for skin microvascular reactivity,
Cable, Tim, Roche, Denise, Stratton, Gareth, Roche, Denise M., Edmunds, Sarah, Didi, Mo   +5 more
core  

Coronary microvascular dysfunction is associated with impaired cognitive function: the Cerebral-Coronary Connection study (C3 study)

, 2022
Background It remains unknown whether the presence of coronary microcirculatory dysfunction (CMD) correlates with its equivalent conditionin the brain, cerebral small vessel disease (CSVD).
de Diego, Jose Juan Gomez, Espejo-Paeres, Carolina, Bustos García De Castro, Ana María, Escaned, Javier, Modrego Martín, Javier, Delgado Álvarez, Alfonso, Gómez-Escalonilla, Carlos Ignacio, Gómez Garre, María Dulce Nombre, Pérez De Isla, Leopoldo, Ortega-Hernandez, Adriana, Mejía Rentería, Hernán, Matías-Guiu, Jordi A, Bustos, Ana, Yus, Miguel, Arrazola García, Juan Lorenzo, Reneses Prieto, Blanca María Asunción, Mejia-Renteria, Hernan, Reneses-Prieto, Blanca, Gómez de Diego, José Juan, Ortega Hernández, Adriana, Modrego-Martin, Javier, Finocchiaro, Francesca, Fernández, Sara, Escaned Barbosa, Javier, Arrazola-García, Juan, Gómez-Garré, Maria Dulcenombre, Matías-Guiu Guía, Jorge, Matías-Guiu, Jorge, Espejo Paeres, Carolina, Travieso, Alejandro, Delgado-Alvarez, Alfonso, Papadopoulos, Petros, Fernández Guinea, Sara Belén   +32 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Systemic and Cardiac Microvascular Dysfunction in Hypertension [PDF]

Hypertension exerts a profound impact on the microcirculation, causing both structural and functional alterations that contribute to systemic and organ-specific vascular damage.
Mazzapicchi A., Durante A., Baiardo Redaelli M.   +2 more
core   +2 more sources

Coronary Microvascular Dysfunction: A Guide for Clinicians

Dysfunction of the coronary microvasculature has become increasingly recognized as an important mechanism of myocardial ischemia in patients without obstructive coronary artery disease.
Smati, Hannah, Qadeer, Yusuf, Sellke, Frank W, Montone, Rocco A, Niccoli, Giampaolo, Krittanawong, Chayakrit, Bourque, Jamieson M   +6 more
core   +2 more sources

Tissue microvascular flow and oxygenation in critically ill patients

, 2012
PhDThe use of fluid resuscitation and vasoactive agents to optimise global haemodynamics has been demonstrated to improve outcomes in patients undergoing major surgery and in early sepsis.
Jhanji, Shaman
core  

Reversible microvascular dysfunction coupled with persistent myocardial dysfunction: implications for post-infarct left ventricular remodelling.

, 2007
BACKGROUND: Recent studies have shown that microvascular dysfunction after myocardial infarction is a dynamic phenomenon. AIMS: To evaluate the implications of dynamic changes in microvascular dysfunction on contractile recovery and left ventricular ...
F. A. Gabrielli, Galiuto, Leonarda, La Torre, Giuseppe, A. Scara, Lombardo, Antonella, Crea, Filippo, F. Crea, A. Lombardo, A. G. Rebuzzi, Rebuzzi, Antonio Giuseppe, L. Galiuto, Scara', Antonio, Gabrielli, Francesca Augusta   +12 more
core   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source