Results 91 to 100 of about 203,456 (311)

Circulating exosomal mir-16-2-3p is associated with coronary microvascular dysfunction in diabetes through regulating the fatty acid degradation of endothelial cells

Cardiovascular Diabetology
Background Coronary microvascular dysfunction (CMD) is a frequent complication of diabetes mellitus (DM) characterized by challenges in both diagnosis and intervention.
Yihai Liu, Chongxia Zhong, Shan Chen, Yanan Xue, Zhonghai Wei, Li Dong, Lina Kang   +6 more
doaj   +1 more source

Pioglitazone Prevents Capillary Rarefaction in Streptozotocin-Diabetic Rats Independently of Glucose Control and Vascular Endothelial Growth Factor Expression [PDF]

, 2012
Background/Aims: Reduction of capillary network density occurs early in the development of metabolic syndrome and may be relevant for the precipitation of diabetes.
Andreas Dendorfer, Arany Z, Astrid Ashoff, Baraka A, Battegay EJ, Billiet L, Biscetti F, Blasi ER, Chintalgattu V, Cipolla MJ, Dendorfer A, Duan SZ, Emanueli C, Emoto M, Fatimunnisa Qadri, Frisbee JC, Frisbee JC, Frisbee JC, Gealekman O, Geraldes P, Goodwill AG, Han B, Heidbreder M, Kobayashi N, Levy BI, Lillioja S, Lindenmeyer MT, Nishikawa T, Noon JP, Ohga S, Olaf Jöhren, Polikandriotis JA, Prewitt RL, Redondo S, Reinhard Eggers, Romeo G, Son NH, Thangarajah H, Vogt CJ, Walter Raasch, Weidner N, Yue Tl TL, Zolk O   +42 more
core   +1 more source

Acanthamoeba interactions with human brain microvascular endothelial cells

Microbial Pathogenesis, 2003
Acanthamoeba are opportunistic protozoan parasites that can cause fatal granulomatous amoebic encephalitis, however, the pathogenic mechanisms associated with this disease remain unclear. One of the primary factors in Acanthamoeba encephalitis is the haematogenous spread, followed by invasion of the blood-brain barrier resulting in the transmigration ...
Ortega Rivas, Antonio, Alsam, Selwa, Kim, Kwang Sik, Stins, Monique, Sissons, James, Khan, Naveed Ahmed   +5 more
openaire   +3 more sources

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence.

PLoS Pathogens, 2019
Polyomavirus BKV is highly prevalent among humans. The virus establishes an asymptomatic persistent infection in the urinary system in healthy people, but uncontrolled productive infection of the virus in immunocompromised patients can lead to serious ...
Ping An, Maria Teresa Sáenz Robles, Alexis M Duray, Paul G Cantalupo, James M Pipas   +4 more
doaj   +1 more source

Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]

, 2013
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa, Compte, Marta, Cuesta, Ángel M., Fernández-Periáñez, Rodrigo, Guijarro-Muñoz, Irene, Molina-Privado, Irene, Rojo, Federico, Sanz, Laura, Sánchez-Martín, David, Zazo, Sandra, Álvarez-Cienfuegos, Ana, Álvarez-Méndez, Ana M., Álvarez-Vallina, Luis   +12 more
core   +4 more sources

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source

Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development

Frontiers in Cell and Developmental Biology, 2020
Sonic hedgehog (Shh) pathway disruption causes craniofacial malformations including orofacial clefts (OFCs) of the lip and palate. In normal craniofacial morphogenesis, Shh signals to multipotent cranial neural crest cells (cNCCs) and was recently ...
Miranda R. Sun, Hannah M. Chung, Hannah M. Chung, Veronika Matsuk, Veronika Matsuk, Dustin M. Fink, Matthew J. Stebbins, Sean P. Palecek, Eric V. Shusta, Eric V. Shusta, Robert J. Lipinski, Robert J. Lipinski   +11 more
doaj   +1 more source

Isolation of equine endothelial cells and life cell angiogenesis assay [PDF]

, 2014
Arterial or venous thromboses are frequent clinical complications with the risk of fatal progression. Recent studies suggest the disruption of angiogenesis in the course of thrombus resolution as the underlying pathomechanism.
Dietze, Kathrin, Fuhrmann-Selter, Tania, Hopperdietzel, Carsten, Kaessmeyer, Sabine, Plendl, Johanna, Slosarek, Ilka   +5 more
core   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source