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Mechanobiology of microvesicle release, uptake, and microvesicle-mediated activation
2020Microvesicles are small, membrane-bound vesicles that are shed from the plasma membrane of cells into the extracellular space. Microvesicles contain a variety of cargo not typically thought to be released from cells, including receptor tyrosine kinases, cytosolic signaling proteins, and microRNAs, which are transferred from donor cells to recipient ...
Cynthia A. Reinhart-King +1 more
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Microvesicles in Health and Disease
Archivum Immunologiae et Therapiae Experimentalis, 2012Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuant signal transduction, including the transport of ...
Sigrun Lange +6 more
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Tumor-derived microvesicles: The metastasomes
Medical Hypotheses, 2013Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route.
Ghasemi R +6 more
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Microvesicles in Autoimmune Diseases
2016During apoptosis or activation, cells can release a subcellular structure, called a membrane microvesicle (also known as microparticle) into the extracellular environment. Microvesicles bud-off as a portion of cell membrane with its associated proteins and lipids surrounding a cytosolic core that contains intracellular proteins, lipids, and nucleic ...
Victoria P. Werth +3 more
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Shedding microvesicles: artefacts no more
Trends in Cell Biology, 2009The small vesicles shed from the surface of many cells upon stimulation, considered for a long time to be artefacts, are now recognized as specific structures that are distinct from the exosomes released upon exocytosis of multivesicular bodies. Recent reports indicate that shedding vesicles participate in important biological processes, such as the ...
Emanuele Cocucci +2 more
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Microvesicles and exosomes for intracardiac communication
Cardiovascular Research, 2014The heart is an organ with a complex mixture of well-organized interactions of different cell types that facilitate proper myocardial contractility, sufficient perfusion, balanced myocardial extracellular stiffness, and controlled functioning of the immune system.
Janine C. Deddens +4 more
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Microvesicles and pre-eclampsia
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2013The maternal syndrome of pre-eclampsia is characterised by an excessive inflammatory response associated with endothelial dysfunction, brought about by the release of multiple factors from the placenta into the maternal circulation. While some of these factors are released as soluble molecules it is now apparent that many of them are associated with ...
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Proteins Regulating Microvesicle Biogenesis and Multidrug Resistance in Cancer
Proteomics, 2019Microvesicles (MV) are emerging as important mediators of intercellular communication. While MVs are important signaling vectors for many physiological processes, they are also implicated in cancer pathology and progression.
Jack Taylor, M. Bebawy
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Blood/plasma secretome and microvesicles
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013A major but hitherto overseen component of the blood/plasma secretome is that of extracellular vesicles (EVs) which are shed from all blood cell types. These EVs are made up of microvesicles (MVs) and exosomes. MVs, 100nm-1μm in diameter, are released from the cell surface, and are a rich source of non-conventionally secreted proteins lacking a ...
Sarah Azam +5 more
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The Role of Microvesicles in Malignancies
2011Microvesicles are membrane-covered cell fragments whose size varies between 30 and 1,000 nm. They are generated by all cell types, constituvely and in response to activation signals. Their importance in intercellular communication has been only recently discovered.
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