Results 121 to 130 of about 52,706 (185)

Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole‐body passive hyperthermia in healthy humans

Experimental Physiology, EarlyView.
Abstract Hyperthermia can cause intestinal injury, facilitating endotoxin translocation and an inflammatory response that has been associated with heat illness. However, the potential occurrence of these responses has been incompletely reported during passive hyperthermia, and the independent effect of hyperthermia is equivocal.
Oliver R. Gibson, Orlando Laitano, Kazuhito Watanabe, José González‐Alonso   +3 more
wiley   +1 more source

Circulating extracellular microvesicles associated with electronic cigarette use increase endothelial cell inflammation and reduce nitric oxide production

Experimental Physiology
The purpose of this study was to determine the effect of circulating microvesicles isolated from chronic electronic (e‐)cigarette users on cultured human umbilical vein endothelial cell (HUVEC) expression of nuclear factor‐κB (NF‐κB), cellular cytokine ...
Nicholas G. Evanoff, Donald R. Dengel, Kelly A. Stockelman, Hannah Fandl, Noah M. DeSouza, Jared J. Greiner, Sheena R. Dufresne, Michael Kotlyar, Vinicius P. Garcia   +8 more
doaj   +1 more source

Whole‐body hot water immersion effect on cerebral haemodynamics and subsequent cerebrovascular reactivity to carbon dioxide

Experimental Physiology, EarlyView.
Abstract To test the hypothesis that hot water immersion (HWI) improves cerebrovascular function via shear‐mediated mechanisms, this study determined cerebrovascular reactivity to carbon dioxide (CVRCO2${\mathrm{CV}}{{\mathrm{R}}_{{\mathrm{C}}{{\mathrm{O}}_2}}}$) before and after 60 min of 39°C HWI and a 21°C air control (CON) in 15 healthy ...
Samuel F. Leaney, Ester Tommasini, Guto W. Hughes, Alison M. Shepherd, Nyah D. Kingdon, Justin S. Lawley, Geoff B. Coombs, Jonathan P. Moore, Samuel J. Oliver   +8 more
wiley   +1 more source

Cerebrovascular regulation during heat stress

Experimental Physiology, EarlyView.
Abstract Given that the brain is a highly metabolic organ and is enclosed by the skull, effective regulation of cerebral blood flow (CBF), not only for oxygen and nutrients supply but also as a means of convective heat exchange, is critical for preventing excessive elevations in brain temperature.
Kanoko Ito, Manabu Shibasaki
wiley   +1 more source

Leukemia cell microvesicles promote survival in umbilical cord blood hematopoietic stem cells [PDF]

, 2015
Microvesicles can transfer their contents, proteins and RNA, to target cells and thereby transform them. This may induce apoptosis or survival depending on cell origin and the target cell.
Kafi-abad, Sedigheh Amini, Karimi, Mohammad Hossein, Mehrabani, Davood, Razmkhah, Farnaz, Soleimani, Masoud   +4 more
core  

Periodontitis and extracellular vesicles: Emerging roles in inflammation, tissue destruction and systemic crosstalk

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Extracellular vesicles released from periodontal tissues and pathogens mediate local inflammation and disseminate systemically via the circulation. By transporting regulatory microRNAs and inflammatory cytokines, these vesicles link periodontitis to systemic inflammatory conditions and represent emerging targets for minimally invasive diagnostics and ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

Small and Large Extracellular Vesicles in Circulation of Diffuse Large B‐Cell Lymphoma Patients Originate From Different Cell Types of the Tumor Microenvironment

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Malignant and non‐malignant cells within the tumor microenvironment (TME) actively secrete extracellular vesicles (EVs) that may mediate intercellular communication or enter the blood stream. Circulating EVs in Diffuse Large B‐Cell Lymphoma (DLBCL) patients are a promising source of liquid biopsy biomarkers; however, whether different cellular
Filippo Maltoni, Steven Wang, Mischa. F. B. Steketee, Cristina A. Gómez‐Martín, Esther E. E. Drees, Federica Morelli, Leontien Bosch, Monique van Eijndhoven, Gert Jan Timmers, Ilse Houtenbos, Josée M. Zijlstra, Xiaofei Ye, Qiang Pan‐Hammarström, Martine E. D. Chamuleau, Pier Luigi Zinzani, Yongsoo Kim, Lucia Catani, Dirk Michiel Pegtel   +17 more
wiley   +1 more source

Tissue factor, factor VIII and IX in microvesicle-induced thrombosis and tumor growth of pancreatic cancer

Thrombosis Journal
Background Tissue factor (TF)-rich cancer microvesicles are correlated with thrombosis risk. Intrinsic coagulation factors are also associated with the risk of thrombosis in cancer patients.
Sheng-Chieh Chou, Shu-Lun Chang, Cheng-Yeh Yu, Chao-I Lin, Yen-Ting Chang, Li-Fu Chen, Jia-Yi Li, Chen‑Hsueh Pai, Shu-Rung Lin, Wern-Cherng Cheng, Chang-Tsu Yuan, Shu-Wha Lin   +11 more
doaj   +1 more source

Targeting compensatory proliferation signals in oral cancer

Journal of Oral Biology and Craniofacial Research
Apoptosis is an orchestrated phenomenon that regulates cell populations in physiological and pathological conditions. Carcinogenesis involves a state of disequilibrium between cell proliferation and cell death.
Loganathan Kavitha, Vijayashree Priyadharsini J, Anitha P, Paramasivam A   +3 more
doaj   +1 more source

Therapeutic and diagnostic applications of extracellular vesicles [PDF]

, 2016
De Smedt, Stefaan, Raemdonck, Koen, Stremersch, Stephan   +2 more
core   +1 more source