Results 121 to 130 of about 63,152 (354)

Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells

Fluids and Barriers of the CNS, 2013
Background In addition to possessing intracellular vesicles, eukaryotic cells also produce extracellular microvesicles, ranging from 50 to 1000 nm in diameter that are released or shed into the microenvironment under physiological and pathological ...
Haqqani Arsalan S, Delaney Christie E, Tremblay Tammy-Lynn, Sodja Caroline, Sandhu Jagdeep K, Stanimirovic Danica B   +5 more
doaj   +1 more source

Shiga Toxin-Bearing Microvesicles Exert a Cytotoxic Effect on Recipient Cells Only When the Cells Express the Toxin Receptor

Frontiers in Cellular and Infection Microbiology, 2020
Shiga toxin is the main virulence factor of non-invasive enterohemorrhagic Escherichia coli strains capable of causing hemolytic uremic syndrome. Our group has previously shown that the toxin can reach the kidney within microvesicles where it is taken up
Karl Johansson, Annie Willysson, Ann-Charlotte Kristoffersson, Ashmita Tontanahal, Daniel Gillet, Anne-lie Ståhl, Diana Karpman   +6 more
doaj   +1 more source

Mechanisms of endothelial cell dysfunction in cystic fibrosis [PDF]

, 2017
Although cystic fibrosis (CF) patients exhibit signs of endothelial perturbation, the functions of the cystic fibrosis conductance regulator (CFTR) in vascular endothelial cells (EC) are poorly defined.
Anile, Marco, Cianci, Eleonora, Del Porto, Paola, Dell'Elba, Giuseppe, Di Silvestre, Sara, Evangelista, Virgilio, Guarnieri, Simone, Lanuti, Paola, Marchisio, Marco, Mari, Veronica C., Mariggiã², Maria A., Moretti, Paolo, Mucilli, Felice, Pandolfi, Assunta, Patruno, Sara, Piccoli, Antonio, Plebani, Roberto, Prioletta, Marco, Recchiuti, Antonio, Romano, Mario, Sacchetti, Silvio, Totani, Licia, Venuta, Federico   +22 more
core   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Ca2+ uptake to purified secretory vesicles from bovine neurohypophyses [PDF]

, 1982
Purified secretory vesicles isolated from bovine neurohypophyses were found to take up Ca2+ when incubated at 30°C in media containing 10−7 to 10−4 M free Ca2+. At 10−4 free Ca2+ 19 nmol/mg protein were taken up within 30 min.
Baker, Banks, Barer, Blaustein, Borle, Bowman, Böhlen, Conigrave, Crompton, Dicker, Ginsburg, Gratzl, Gratzl, Heidemarie I. Krieger-Brauer, Krieger-Brauer, Krieger-Brauer, Lehninger, Lehninger, Manfred Gratzl, Morris, Niels A. Thorn, Normann, Olsen, Pressman, Rasmussen, Robinson, Russell, Saermark, Thorn, Thorn, Torben Særmark, Torp-Pedersen, Torp-Pedersen, Vilhardt, Vilhardt, Weiss   +35 more
core   +1 more source

Microvesicles in disease

, 2014
On activation cells shed vesicles from their surface by the process of ectocytosis. These micro-vesicles or Ectosomes express phosphatidyl-serine (PS) on their surface, which can elicit a range of biological effects from immune-suppression to the activation of the clotting and complement pathways.
openaire   +3 more sources

The Immunomodulatory Role of Syncytiotrophoblast Microvesicles

PLoS ONE, 2011
Immune adaptation is a critical component of successful pregnancy. Of primary importance is the modification of cytokine production upon immune activation. With the discovery that normal pregnancy itself is a pro-inflammatory state, it was recognised that the classical Th1/Th2 cytokine paradigm, with a shift towards 'type 2' cytokine production ...
Southcombe, J, Tannetta, D, Redman, C, Sargent, I   +3 more
openaire   +6 more sources

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

Advanced NanoBiomed Research, EarlyView.
The advent of organ‐on‐chip models allows closer emulation of in vivo conditions, leading to effective, less costly, and specific drugs. Although a number of membrane‐based on‐chip models exist, better emulating functional models need to be devised for organ simulations.
Tanmayee Makarand Sathe, Dhananjay Shrikrishna Bodas   +1 more
wiley   +1 more source

Biology and biogenesis of shed microvesicles

Small GTPases, 2016
The ability of cells to transmit bioactive molecules to recipient cells and the extracellular environment is a fundamental requirement for both normal physiology and disease pathogenesis.
Christopher J. Tricarico, James W. Clancy, C. D’Souza-Schorey   +2 more
semanticscholar   +1 more source

Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. [PDF]

, 2016
Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that ...
A Acosta-Serrano, A Buschiazzo, A Egner, A Galetovic, Andrés B. Lantos, AS Couto, BB Diaz-Rohrer, Beatriz Araoz, CA Buscaglia, CA Buscaglia, Carlos A. Buscaglia, Carolyn R. Bertozzi, DC Bartholomeu, E Bayer-Santos, EJ Finkelsztein, G Bernabo, Giannina Carlevaro, GM Rocha, GM Rocha, GT Dempsey, H Yu, Hai Yu, HT McMahon, HT McMahon, I Levental, I Urban, IA Oliveira, IC Almeida, IC Almeida, J Folling, J Zimmerberg, JA Prescher, JA Prescher, JC Jewett, JH Lumb, JM Baskin, JM Di Noia, JM Di Noia, Juan Mucci, K Simons, KM Tyler, LM De Pablos, LM Freitas, M Hashimoto, Malcolm J. McConville, Mariano Bossi, María de los Milagros Camara, MdL Camara, ME Giorgi, MF Goncalves, MG Risso, ML Salto, MM Camargo, MS Leguizamón, MV Gudheti, NM Quanquin, NW Andrews, Oscar Campetella, P Ruiz Diaz, Pablo Ruiz Diaz, PN Ulrich, RE Thompson, RM de Lederkremer, RP Muiá, S Niyogi, S Schenkman, S Schenkman, S Schenkman, S Tomlinson, SS Rubin de Celis, T Furuya, TJ Gould, Torrecilhas AC Trocoli, U Frevert, V de Paulo Martins, V Jimenez, VA Campo, Vde P Martins, VL Pereira-Chioccola, W de Souza, W de Souza, WB Huttner, X Xu, Xi Chen   +83 more
core   +5 more sources