Results 131 to 140 of about 31,187 (277)
Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation.
Ingrid Lopatko Fagerström+10 more
doaj
Human Tumor-Released Microvesicles Promote the Differentiation of Myeloid Cells with Transforming Growth Factor-β–Mediated Suppressive Activity on T Lymphocytes [PDF]
Roberta Valenti+9 more
openalex +1 more source
Extracellular vesicles (EVs) derived from myeloma cells could potentially induce T cell exhaustion via the increase of the frequency of immune checkpoint marker‐positive CD8+ T cells and might thereby suppress T cell function. In addition, this immune escape mechanism from cytotoxic T cells is supported by the findings on SPHK1/S1P signaling from SPHK1‐
Shinya Hagiwara+13 more
wiley +1 more source
Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei+5 more
wiley +1 more source
Alteration of Marrow Cell Gene Expression, Protein Production, and Engraftment into Lung by Lung-Derived Microvesicles: A Novel Mechanism for Phenotype Modulation [PDF]
Jason M. Aliotta+16 more
openalex +1 more source
A review of the equine suspensory ligament: Injury prone yet understudied
Abstract The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the energetic cost of locomotion.
Deborah J. Guest+2 more
wiley +1 more source
The mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. Here, we test the hypothesis that mitochondrial transfer from mammary epithelial cells to breast cancer cells plays a role in this redirection process.
Julie Sofie Bjerring+4 more
wiley +1 more source
WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert+16 more
wiley +1 more source
Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie+3 more
wiley +1 more source