Results 131 to 140 of about 31,187 (277)

Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammationResearch in context

open access: yesEBioMedicine, 2019
Background: The complement and kallikrein-kinin systems (KKS) are activated during vascular inflammation. The aim of this study was to investigate if blockade of the KKS can affect complement activation on the endothelium during inflammation.
Ingrid Lopatko Fagerström   +10 more
doaj  

Human Tumor-Released Microvesicles Promote the Differentiation of Myeloid Cells with Transforming Growth Factor-β–Mediated Suppressive Activity on T Lymphocytes [PDF]

open access: bronze, 2006
Roberta Valenti   +9 more
openalex   +1 more source

Immunosuppressive Effects of Multiple Myeloma‐Derived Extracellular Vesicles Through T Cell Exhaustion

open access: yesCancer Science, EarlyView.
Extracellular vesicles (EVs) derived from myeloma cells could potentially induce T cell exhaustion via the increase of the frequency of immune checkpoint marker‐positive CD8+ T cells and might thereby suppress T cell function. In addition, this immune escape mechanism from cytotoxic T cells is supported by the findings on SPHK1/S1P signaling from SPHK1‐
Shinya Hagiwara   +13 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

open access: yesCell Proliferation, EarlyView.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei   +5 more
wiley   +1 more source

Alteration of Marrow Cell Gene Expression, Protein Production, and Engraftment into Lung by Lung-Derived Microvesicles: A Novel Mechanism for Phenotype Modulation [PDF]

open access: bronze, 2007
Jason M. Aliotta   +16 more
openalex   +1 more source

A review of the equine suspensory ligament: Injury prone yet understudied

open access: yesEquine Veterinary Journal, EarlyView.
Abstract The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the energetic cost of locomotion.
Deborah J. Guest   +2 more
wiley   +1 more source

Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate

open access: yesThe FEBS Journal, Volume 292, Issue 9, Page 2306-2322, May 2025.
The mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. Here, we test the hypothesis that mitochondrial transfer from mammary epithelial cells to breast cancer cells plays a role in this redirection process.
Julie Sofie Bjerring   +4 more
wiley   +1 more source

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

open access: yesThe FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert   +16 more
wiley   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

open access: yesThe FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie   +3 more
wiley   +1 more source

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

open access: bronze, 1995
Olivier Fourcade   +8 more
openalex   +1 more source

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