Results 211 to 220 of about 63,152 (354)

Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro‐Glial Protection Against Cerebral Ischemia

MedComm, Volume 7, Issue 2, February 2026.
Treadmill training protects against white matter injury and reduces cerebral infarction. Muscle‐derived mitochondrial transfer via platelets is promoted by treadmill training. Platelet transfusion emerges as a potential low‐risk therapeutic strategy for sequelae and vascular dementia.
Toshiki Inaba, Nobukazu Miyamoto, Kenichiro Hira, Chikage Kijima, Yoshifumi Miyauchi, Hai‐Bin Xu, Kazo Kanazawa, Yuji Ueno, Nobutaka Hattori   +8 more
wiley   +1 more source

Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding [PDF]

, 2023
Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian I. Bell, David A. Hess, Guangxin Xing, Ling Hong, Dylan Burger, Qingping Feng   +9 more
openalex   +1 more source

Clinical Validation of α‐Synuclein in Salivary Extracellular Vesicles as a Biomarker for Parkinson's Disease: A Longitudinal Study

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Salivary Extracellular vesicles (SEVs) isolated from PD patients exhibit increased levels of both total (α‐SynTot) and oligomeric alpha‐synuclein (α‐SynOlig). In PD patients, SEVS‐α‐SynOlig levels correlate with cognitive decline (MMSE) and motor fluctuations (MDS‐UPDRS IV) and remain stable after 1 year follow‐up.
Antonia Gurgone, Vita Cardinale, Marta M. Tangari, Serena Budicin, Debora Comai, Claudia Ledda, Leonardo Lopiano, Giovanni Camussi, Maurizio Zibetti, Maurizio Giustetto   +9 more
wiley   +1 more source

Microvesicles in sepsis

, 2018
Zielsetzung Dem Endothel wird eine zentrale Rolle in der Pathogenese des septischen Schocks zugeschrieben. Da bei diversen Erkrankungen, bei denen eine Mitbeteiligung des Endothels vorhanden ist, erhöhte Level endothelialer Mikrovesikel (MV) gefunden wurden, werden diese als Surrogatparameter angesehen, die den Zustand des Endothels widerspiegeln. Ziel
openaire   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source

LncRNA DANCR Activates p38/mTOR‐Mediated Autophagy via ANXA2 to Exacerbate Oxygen‐Induced Retinal Neovascularization in Mice

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
This study reveals that the long non‐coding RNA DANCR drives pathological retinal neovascularization in oxygen‐induced retinopathy via an ANXA2‐dependent p38/MAPK/mTOR autophagy pathway. In hypoxic endothelial cells and a murine OIR model, DANCR promotes angiogenesis.
Yini Wang, Jiale Bai, Shihong Zhao
wiley   +1 more source

Data from Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

, 2023
Cristina Grange, Marta Tapparo, Federica Collino, Loriana Vitillo, Christian Damasco, Maria Chiara Deregibus, Ciro Tetta, Benedetta Bussolati, Giovanni Camussi   +8 more
openalex   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, Volume 16, Issue 1, Page 127-144, January 2026.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Extracellular Vesicles Derived From Mesenchymal Bone Marrow Cells Promote Antinociception in a Murine Model of Diabetic Neuropathy via the Endogenous Opioid System

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study investigates the analgesic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (EV‐BMSC) in diabetic sensory neuropathy. EV‐BMSC reproduce the pain‐relieving effects of BMSC transplantation through opioid‐mediated mechanisms, highlighting a promising cell‐free therapeutic approach for neuropathic pain ...
Gessica S. A. Silva, Afrânio F. Evangelista, Girlaine C. Santos, Thaís A. Santana, Luiza C. F. Opretzka, Pedro S. S. Lauria, Marco A. Stimamiglio, Milena B. P. Soares, Cristiane F. Villarreal   +8 more
wiley   +1 more source