Results 241 to 250 of about 63,152 (354)

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

open access: yesInterdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian   +6 more
wiley   +1 more source

Assessment of frailty in patients with advanced chronic kidney disease, and the role of microvesicles: A single-center study. [PDF]

open access: yesPLoS One
Gimena Muñoz R   +9 more
europepmc   +1 more source

Lactadherin and clearance of platelet-derived microvesicles [PDF]

open access: bronze, 2008
Swapan Dasgupta   +8 more
openalex   +1 more source

Extracellular vesicle‐based vaccines and immunotherapeutics for treatment of cancer

open access: yesInterdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review highlights the innovative value of extracellular vesicles (EVs) as cancer vaccines and immunotherapy carriers. EVs have natural advantages such as low immunogenicity, high biocompatibility, stability, and precise targeting, enabling efficient delivery of tumor antigens (e.g., HER2, AFP) and immune stimulants (e.g., TLR ligands, cytokines ...
Lejia Tan   +4 more
wiley   +1 more source

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger   +6 more
wiley   +1 more source

Myofibroblast‐Derived Extracellular Vesicles Drive Profibrotic Cascade Amplification in Pulmonary Fibrosis via the Nestin‐Rab7 Axis

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease characterized by aberrant myofibroblast activation and excessive extracellular matrix deposition, with extracellular vesicles (EVs) playing a crucial role in this pathological process. We observed that EVs levels are significantly elevated in IPF and positively correlate with
Xiaofan Lai   +14 more
wiley   +1 more source

TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway. [PDF]

open access: yesCell Commun Signal
Li J   +16 more
europepmc   +1 more source

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