Results 81 to 90 of about 51,554 (307)

The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier

Frontiers in Physiology, 2020
A versatile experimental model for the investigation of the blood-brain barrier (BBB), including the neuro-vascular unit, is the isolated brain microvessel preparation.
William M. Pardridge
doaj   +1 more source

Evans blue dye-enhanced imaging of the brain microvessels using spectral focusing coherent anti-Stokes Raman scattering microscopy. [PDF]

PLoS ONE, 2017
We performed dye-enhanced imaging of mouse brain microvessels using spectral focusing coherent anti-Stokes Raman scattering (SF-CARS) microscopy. The resonant signals from C-H stretching in forward CARS usually show high background intensity in tissues ...
Bo-Ram Lee, Kyung-Il Joo, Eun Sook Choi, Junghoon Jahng, Hyunmin Kim, Eunjoo Kim   +5 more
doaj   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Development of Mathematical Model for Understanding Microcirculation in Diabetic Foot Ulcers Based on Ankle–Brachial Index

Bioengineering
This study proposes an innovative mathematical model for assessing microcirculation in patients with diabetic ulcers, using the ankle–brachial index (ABI).
Ana Karoline Almeida da Silva, Gustavo Adolfo Marcelino de Almeida Nunes, Rafael Mendes Faria , Mário Fabrício Fleury Rosa, Lindemberg Barreto Mota da Costa, Newton de Faria, Adson Ferreira da Rocha , José Carlos Tatmatsu-Rocha, Suelia de Siqueira Rodrigues Fleury Rosa   +8 more
doaj   +1 more source

Precise Cerebral Vascular Atlas in Stereotaxic Coordinates of Whole Mouse Brain

Frontiers in Neuroanatomy, 2017
Understanding amazingly complex brain functions and pathologies requires a complete cerebral vascular atlas in stereotaxic coordinates. Making a precise atlas for cerebral arteries and veins has been a century-old objective in neuroscience and ...
Benyi Xiong, Benyi Xiong, Anan Li, Anan Li, Yang Lou, Yang Lou, Shangbin Chen, Shangbin Chen, Ben Long, Ben Long, Jie Peng, Jie Peng, Zhongqin Yang, Zhongqin Yang, Tonghui Xu, Tonghui Xu, Xiaoquan Yang, Xiaoquan Yang, Xiangning Li, Xiangning Li, Tao Jiang, Tao Jiang, Qingming Luo, Qingming Luo, Hui Gong, Hui Gong   +25 more
doaj   +1 more source

Macrophage infiltration of AAA microvessels.

, 2014
A, Elastica van Gieson staining of abdominal aortic aneurysm (AAA). Immunohistochemistry for podoplanin (B) and macrophages (C), CD19 (E), and myeloperoxidase (MPO) of the AAA wall.
Hiroyuki Konno (383104), Masaki Sano (269338), Hiroki Tanaka (352578), Takeshi Sasaki (142838), Kohji Sato (377590), Mitsutoshi Setou (119915), Kazunori Inuzuka (540359), Junichi Sakabe (540356), Satoshi Hirakawa (363802), Mikako Ogawa (540357), Naoki Unno (383105), Naoto Yamamoto (383101), Satoshi Baba (540358), Nobuhiro Zaima (119890)   +13 more
core   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia

Fluids and Barriers of the CNS, 2023
Background Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chronic hypertriglyceridemia, we ...
Beáta Barabási, Lilla Barna, Ana Raquel Santa-Maria, András Harazin, Réka Molnár, András Kincses, Judit P. Vigh, Brigitta Dukay, Miklós Sántha, Melinda E. Tóth, Fruzsina R. Walter, Mária A. Deli, Zsófia Hoyk   +12 more
doaj   +1 more source

Monoamine Oxidase Activity in the Cerebral Vasculature: Comparison between Fresh Microvessels from Different Structures and Cell Cultures Derived from Microvessels

, 1984
Monoamine oxidase (MAO) activity was studied in various preparations of porcine brain microvessels to explore further the role of this enzyme in the blood–brain barrier to catecholamines.
R. Sercombe, F. Lasbennes, L. Drouet, J. Seylaz, A. M. Dosne   +4 more
core   +1 more source

One‐Step Preparation of Lanthanide‐Doped Polyurea Multicolor Microspheres for Versatile Fluorescent Applications

Advanced Science, EarlyView.
Lanthanide‐doped polyurea microspheres are prepared via a facile one‐step precipitation polymerization. They exhibit strong hydrogen‐bonding and coordination interactions with excellent properties, including multicolor emission, high quantum yield (75.3%), remarkable stability, redispersibility, and biocompatibility.
Guiyu Zhang, Xiaoxia Yu, Xinhui Wang, Xiang Zheng Kong, Xiangling Gu, Jitao Liu, Shusheng Li, Xiaoli Zhu, Lianbao Cao, Xubao Jiang   +9 more
wiley   +1 more source