Results 101 to 110 of about 151,098 (403)

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi, Ji Yun Kim, Lisa Seitz, Lixia Jin, Paul G. Foster, Kai H. Liao, Tzuling Cheng, Elaine Paterson, Maria Velinova, Nicole Rivera Rosario, Reza Khosravan, Balaji Agoram   +11 more
wiley   +1 more source

Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability

Molecules, 2020
Midazolam is a rapidly effective benzodiazepine drug that is widely used as a sedative worldwide. Due to its poor solubility in a neutral aqueous solution, the clinical use of midazolam is significantly limited.
Xun Zhang, Zhiguo Li, Jing Gao, Zengming Wang, Xiang Gao, Nan Liu, Meng Li, Hui Zhang, Aiping Zheng   +8 more
doaj   +1 more source

Two Views of Invalid Response Set and Malingering Attributions in Forensic Assessment: Credibility and Non‐Credibility

Behavioral Sciences &the Law, EarlyView.
ABSTRACT This article reviews two major sets of six articles on malingering and invalid response set, which have diametrically opposite conclusions on the value of performance and symptom validity tests (PVTs and SVTs) in forensic and related disability assessments (FDRA). First, we review the six‐article series by the Leonhards, which takes the stance
Gerald Young, Laszlo A. Erdodi, Luciano Giromini   +2 more
wiley   +1 more source

Efficacy and Safety of Midazolam Oral Solution for Sedative Hypnosis and Anti-anxiety in Children: A Systematic Review and Meta-Analysis

Frontiers in Pharmacology, 2020
Background: Midazolam is recommended by health guidelines for sedation and hypnosis in children. Oral solution is a suitable dosage form for children.
Xiao Cheng, Xiao Cheng, Xiao Cheng, Xiao Cheng, Zhe Chen, Zhe Chen, Zhe Chen, Lingli Zhang, Lingli Zhang, Lingli Zhang, Peipei Xu, Peipei Xu, Peipei Xu, Fang Qin, Fang Qin, Fang Qin, Fang Qin, Xuefeng Jiao, Xuefeng Jiao, Xuefeng Jiao, Yiyi Wang, Yiyi Wang, Yiyi Wang, Mao Lin, Mao Lin, Mao Lin, Mao Lin, Linan Zeng, Linan Zeng, Linan Zeng, Liang Huang, Liang Huang, Liang Huang, Liang Huang, Dan Yu, Dan Yu, Dan Yu, Dan Yu   +37 more
doaj   +1 more source

Management of paediatric procedure-related cancer pain

, 1999
Paediatric malignancy is not always painful in its own right; however, young patients with cancer undergo numerous painful procedures for diagnosis, therapy and supportive care, including lumbar puncture, bone marrow aspiration and biopsy.
Liossi, C.
core   +1 more source

Midazolam use for dental conscious sedation: how safe are we? [PDF]

, 2018
Aim: To explore the safety awareness of midazolam use amongst dentist in the UK. Materials and methods: A cross-sectional study on 203 dentists was undertaken, 146 of whom currently practice conscious sedation using intravenous midazolam.
Flood, C, Flood, C, Matthews, L, Matthews, L, Shehbi, Z, Shehbi, Z   +5 more
core   +2 more sources

A comparative study between oral melatonin and oral midazolam on preoperative anxiety, cognitive, and psychomotor functions

Journal of Anaesthesiology Clinical Pharmacology, 2015
Background & Aims: Melatonin, a naturally occurring hormone in the human body, has been reported to cause preoperative anxiolysis and sedation without impairing orientation.
Tushar R. Patel, Madhuri S. Kurdi
semanticscholar   +1 more source

Doctoral Student Supervisors’ Experiences With Broaching Race and Race‐Related Issues

Counselor Education and Supervision, EarlyView.
ABSTRACT In this descriptive phenomenological study, we explored 13 doctoral student supervisors’ experiences with broaching race and race‐related issues in supervision with counselors‐in‐training. Three themes emerged: the function of broaching; self‐perceived attributes affecting broaching; and experiences of programmatic support and challenges.
Judith Wambui Preston, Gülşah Kemer
wiley   +1 more source

Comparison of Oral Midazolam and Promethazine with Oral Midazolam alone for Sedating Children during Computed Tomography

Archives of Academic Emergency Medicine, 2018
Introduction: Both midazolam and promethazine are recommended to be used as sedatives in many studies but each have some side effects that limits their use. Combination therapy as an alternative method, may decreases these limitations.
Hassan Barzegari, Behzad Zohrevandi, Kambiz Masoumi, Arash Forouzan, Ali Asgari Darian, Shaqayeq Khosravi   +5 more
doaj   +1 more source

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source