Results 21 to 30 of about 119,569 (361)
PLoS ONE, 2022 Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to interfere with its ...
Katharina Rump +11 more
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Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
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Midazolam alleviates cellular senescence in SH‐SY5Y neuronal cells in Alzheimer's disease
Brain and Behavior, 2023 Background Alzheimer's disease (AD) impacts the daily life of aging people. Oligomerized amyloid β (Aβ)‐associated neuronal senescence is involved in the pathological mechanism of AD.
Ping Wang +4 more
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Frontiers in Psychiatry, 2023 IntroductionThe aim of the present study was to investigate the behavioral effects of the benzodiazepine midazolam in male mice, in models of anxiolysis, learning, and abuse-related effects.MethodsIn a first set of experiments, male Swiss mice were ...
Caio Jovita-Farias +14 more
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Prescription drug forms with midazolam [PDF]
Farmacja Polska, 2021 Midazolam is a benzodiazepine derivative. It is characterized by a short half-life. It has a strong sedative, anxiolytic and hypnotic effect. It also acts as an anticonvulsant and relaxes skeletal muscles.
Anna Czech, Renata Jachowicz
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Opisthotonos and midazolam [PDF]
Journal of Pediatric Neurology, 2015 A 3-year-child, weighing 11.4 kgs, was admitted in the accident and emergency ward in status epilepticus of more than one hour duration. He was administered diazepam suppository followed by 3 doses of intravenous diazepam. When diazepam failed to control the status epilepticus a loading dose of phenytoin sodium 200 mg (18 mg per kg) was given. This too
Roshan Koul, Javed Hashim, Masod Ahmed
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Perioperative Medicine, 2022 Background Sedative premedication with benzodiazepines has been linked with prolonged recovery and inadequate emergence during the immediate postoperative period.
Karin Stuff +9 more
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Scientific Reports, 2017 The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was
Monika Balk +4 more
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Review of the effects of anesthetic agents used as premedication for patients undergoing electroconvulsive therapy with diagnoses of bipolar disorder or major depression on convulsion, recovery period, and hemodynamic parameters [PDF]
, 2019 Objective: The aim of this study was to examine the effects of anesthetic agents used as premedication in patients undergoing electroconvulsive therapy (ECT) for diagnoses of bipolar disorder or major depression in terms of convulsion, recovery period ...
Orhan, Mehmet Emin, Ozen, Volkan
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Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review
International Journal of Pediatrics, 2014 Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd)
Gian Maria Pacifici
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