Results 21 to 30 of about 147,753 (385)

Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices

Scientific Reports, 2017
The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was
Monika Balk, Harald Hentschke, Uwe Rudolph, Bernd Antkowiak, Berthold Drexler   +4 more
doaj   +1 more source

The effect of transmucosal 0.2mg/kg Midazolam premedication on dental anxiety, anaesthetic induction and psychological morbidity in children undergoing general anaesthesia for tooth extraction [PDF]

, 2008
<b>Background:</b> The project aims were to evaluate the benefit of transmucosal Midazolam 0.2mg/kg pre-medication on anxiety, induction behaviour and psychological morbidity in children undergoing general anaesthesia (GA) extractions. <b&
A Keaney, A. J. Asbury, A. W. Bowman, AL Erlandsson, C Campbell, C Hogg, CK Schmidt, CM Bridgman, D Turkington, GM Humphris, H Buchanan, HM Parsons, HM Wong, J Elander, J Elander, J Rayner, JW Cole, K Millar, K Millar, K. Martin, K. Millar, LM Macpherson, M Rutter, M. T. Hosey, MA Lumley, MI Houpt, MT Hosey, MT Hosey, MT Hosey, NM Girdler, PA Lonnqvist, R Holn-Knudsen, R Seed, R. Welbury, S Calipel, T Horiuchi, T. Musiello, TA Bates, TK Howell, TN Johnson, V Carstairs, YP Ko   +41 more
core   +1 more source

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial

Chinese Medical Journal, 2019
Background: Postoperative cognitive dysfunction (POCD) is a serious complication after surgery, especially in elderly patients. The anesthesia technique is a potentially modifiable risk factor for POCD. This study assessed the effects of dexmedetomidine,
Wei-xia Li, Ruyi Luo, Chao Chen, Xiang Li, Jing-sheng Ao, Yue Liu, Yiqing Yin   +6 more
semanticscholar   +1 more source

Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review

International Journal of Pediatrics, 2014
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd)
Gian Maria Pacifici
doaj   +1 more source

Comparison of nasal Midazolam with Ketamine versus nasal Midazolam as a premedication in children

Saudi Journal of Anaesthesia, 2014
Background: T his study was done to compare effects of intranasal midazolam and intranasal midazolam with ketamine for premedication of children aged 1-12 yrs undergoing intermediate and major surgeries.
Sonal S Khatavkar, Rochana G Bakhshi
doaj   +1 more source

Continuous intravenous versus intermittent bolus midazolam with remifentanil during arteriovenous fistula placement with monitored anesthesia care in chronic renal failure patients: a randomized controlled trial

Annals of Saudi Medicine, 2020
BACKGROUND: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure.
Gonul Sagiroglu, Ayse Baysal
doaj   +1 more source

Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design

Perioperative Medicine, 2022
Background Sedative premedication with benzodiazepines has been linked with prolonged recovery and inadequate emergence during the immediate postoperative period.
Karin Stuff, Elena Kainz, Ursula Kahl, Hans Pinnschmidt, Stefanie Beck, Franziska von Breunig, Rainer Nitzschke, Sandra Funcke, Christian Zöllner, Marlene Fischer   +9 more
doaj   +1 more source

Review of the effects of anesthetic agents used as premedication for patients undergoing electroconvulsive therapy with diagnoses of bipolar disorder or major depression on convulsion, recovery period, and hemodynamic parameters [PDF]

, 2019
Objective: The aim of this study was to examine the effects of anesthetic agents used as premedication in patients undergoing electroconvulsive therapy (ECT) for diagnoses of bipolar disorder or major depression in terms of convulsion, recovery period ...
Orhan, Mehmet Emin, Ozen, Volkan
core   +2 more sources

Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters—a randomized, double‐blind, placebo‐controlled trial

Epilepsia, 2019
To evaluate the safety and efficacy of a novel formulation of midazolam administered as a single‐dose nasal spray (MDZ–NS) in the outpatient treatment of patients experiencing seizure clusters (SCs).
K. Detyniecki, Peter J. Van Ess, David J. Sequeira, J. Wheless, T. Meng, W. Pullman   +5 more
semanticscholar   +1 more source