Results 31 to 40 of about 76,936 (284)

Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review

International Journal of Pediatrics, 2014
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd)
Gian Maria Pacifici
doaj   +1 more source

Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design

Perioperative Medicine, 2022
Background Sedative premedication with benzodiazepines has been linked with prolonged recovery and inadequate emergence during the immediate postoperative period.
Karin Stuff, Elena Kainz, Ursula Kahl, Hans Pinnschmidt, Stefanie Beck, Franziska von Breunig, Rainer Nitzschke, Sandra Funcke, Christian Zöllner, Marlene Fischer   +9 more
doaj   +1 more source

Applications of human microdosing with accelerator mass spectrometry: assessment of ability to predict drug-drug interactions and determine the pharmacokinetics of enantiomers [PDF]

, 2012
In this thesis, new applications of microdosing were explored in two clinical trials. Methods were developed for the separation and quantification of 14C-labelled analytes in human plasma using two-dimensional HPLC and accelerator mass ...
Croft, M L
core   +6 more sources

Continuous intravenous versus intermittent bolus midazolam with remifentanil during arteriovenous fistula placement with monitored anesthesia care in chronic renal failure patients: a randomized controlled trial

Annals of Saudi Medicine, 2020
BACKGROUND: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure.
Gonul Sagiroglu, Ayse Baysal
doaj   +1 more source

"In-vivo" phenotyping of CYP3A using midazolam as probe drug : development of novel approaches based on highly sensitive LC-MS/MS methods [PDF]

, 2011
Cytochrome P450 (CYP) 3A is the most important subfamily of drug-metabolizing enzymes in humans, responsible for metabolizing more than 50% of the currently marketed drugs.
Link, Bettina
core   +1 more source

Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundSoman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic ...
Won Seog Chong, Chang Lim Hyun, Min Kyu Park, Jeong Min Park, Hyun-Ouk Song, Taejin Park, Young Su Lim, Choon Kyu Cho, Po Soon Kang, Hee Uk Kwon   +9 more
doaj   +1 more source

High rates of midazolam injection among drug users in Bangkok, Thailand

Harm Reduction Journal, 2010
Background Reports from Thailand suggest that a growing number of people who inject drugs (IDU) are now injecting midazolam, a legal benzodiazepine with potent amnestic and ventilatory depressant effects.
Suwannawong Paisan, Hayashi Kanna, Fairbairn Nadia, Kiatying-Angsulee Niyada, Kerr Thomas, Kaplan Karyn, Lai Calvin, Wood Evan   +7 more
doaj   +1 more source

Intranasal midazolam alone versus midazolam/ketamine combination for preoperative sedation in pediatric patients undergoing ophthalmic procedures: a randomized controlled trial

Ain Shams Journal of Anesthesiology, 2022
Background Interaction with medical providers is a stressful experience for a child. The current study aimed to assess the efficacy and safety of intranasal midazolam alone versus midazolam/ketamine combination for preoperative sedation prior to ...
Noha A. Osama, Sara R. Mahmoud, Abeer S. Salem, Dalia S. Tawfik   +3 more
doaj   +1 more source

Hubungan Kadar Midazolam Plasma Ibu Dan Bayi Dengan Kondisi Fisik Serta Waktu Persalinan Pada Pasien Sectio Caesaria Yang Mendapat Premedikasi Midazolam Intravena

JAI (Jurnal Anestesiologi Indonesia), 2010
Latar belakang: Premedikasi midazolam rutin diberikan pada anestesi spinal karena sangat bermanfaat untuk memberikan efek sedasi, amnesia, menghilangkan kecemasan.
Eva Susana Putri, Uripno Budiono, Heru Dwi Jatmiko   +2 more
doaj   +1 more source

Old Is (Not) Gold: Midazolam Monotherapy versus Midazolam Plus Fentanyl for Sedation during Cardiac Catheterization

Journal of Interventional Cardiology, 2021
Objective. We aimed to study the differences in perception of pain during cardiac catheterization with midazolam monotherapy compared to the current standard of midazolam plus fentanyl. Background.
William Black, Raj Baljepally, Laylan Shali, Omar Alsharif, Scott Warden, Eric Heidel, Xiaopeng Zhao   +6 more
doaj   +1 more source