Results 21 to 30 of about 71,642 (287)

Midazolam alleviates cellular senescence in SH‐SY5Y neuronal cells in Alzheimer's disease

Brain and Behavior, 2023
Background Alzheimer's disease (AD) impacts the daily life of aging people. Oligomerized amyloid β (Aβ)‐associated neuronal senescence is involved in the pathological mechanism of AD.
Ping Wang, Peipei Wang, Hengfei Luan, Yong Wu, Ying Chen   +4 more
doaj   +1 more source

Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats. [PDF]

, 2009
Some intravenous anesthetic agents such as midazolam are known to induce anterograde and retrograde amnesia. We analyzed the effect of midazolam by the conditioned taste aversion (CTA) acquisition and retention.
Yoshida, Harushi, Ishitobi, Shingo, Ayuse, Takao, Miyamoto, Takenori, Oi, Kumiko, Toda, Kazuo   +5 more
core   +1 more source

Clinical Pharmacology of Midazolam in Neonates and Children: Effect of Disease—A Review

International Journal of Pediatrics, 2014
Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd)
Gian Maria Pacifici
doaj   +1 more source

"In-vivo" phenotyping of CYP3A using midazolam as probe drug : development of novel approaches based on highly sensitive LC-MS/MS methods [PDF]

, 2011
Cytochrome P450 (CYP) 3A is the most important subfamily of drug-metabolizing enzymes in humans, responsible for metabolizing more than 50% of the currently marketed drugs.
Link, Bettina
core   +1 more source

Continuous intravenous versus intermittent bolus midazolam with remifentanil during arteriovenous fistula placement with monitored anesthesia care in chronic renal failure patients: a randomized controlled trial

Annals of Saudi Medicine, 2020
BACKGROUND: There is limited data on the use of intravenous continuous infusion (CI) versus intravenous intermittent bolus (IB) doses of midazolam for conscious sedation in patients with chronic renal failure.
Gonul Sagiroglu, Ayse Baysal
doaj   +1 more source

Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundSoman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic ...
Won Seog Chong, Chang Lim Hyun, Min Kyu Park, Jeong Min Park, Hyun-Ouk Song, Taejin Park, Young Su Lim, Choon Kyu Cho, Po Soon Kang, Hee Uk Kwon   +9 more
doaj   +1 more source

Effects of midazolam vs morphine in patients with acute pulmonary edema with left ventricular systolic dysfunction: a secondary analysis of data from the MIMO trial

, 2023
Objectives: The midazolam vs morphine (MIMO) trial showed that patients treated with midazolam had fewer serious adverse events than those treated with morphine.
Formica, Francesco, Llorens, Pere, Miró, Òscar, Et al., Grupo de Investigadores MIMO (MIdazolam versus MOrfina), Burillo-Putze, Guillermo, Calvo Rodríguez, Rafael, Piñera-Salmerón, Pascual, Martín-Sánchez, Francisco J, Hernández Vaquero, Daniel, Piñera Salmerón, Pascual, MIMO (MIdazolam versus MOrphine), Suero-Méndez, Coral, Domínguez Rodríguez, Alberto , Calvo-Rodríguez, Rafael, Abreu-González, Pedro, Domínguez-Rodríguez, Alberto, Gil, Victor, Suero Méndez, Coral, Martín Sánchez, Francisco Javier, Hernández-Vaquero, Daniel   +20 more
core   +1 more source

Hubungan Kadar Midazolam Plasma Ibu Dan Bayi Dengan Kondisi Fisik Serta Waktu Persalinan Pada Pasien Sectio Caesaria Yang Mendapat Premedikasi Midazolam Intravena

JAI (Jurnal Anestesiologi Indonesia), 2010
Latar belakang: Premedikasi midazolam rutin diberikan pada anestesi spinal karena sangat bermanfaat untuk memberikan efek sedasi, amnesia, menghilangkan kecemasan.
Eva Susana Putri, Uripno Budiono, Heru Dwi Jatmiko   +2 more
doaj   +1 more source

Intranasal midazolam alone versus midazolam/ketamine combination for preoperative sedation in pediatric patients undergoing ophthalmic procedures: a randomized controlled trial

Ain Shams Journal of Anesthesiology, 2022
Background Interaction with medical providers is a stressful experience for a child. The current study aimed to assess the efficacy and safety of intranasal midazolam alone versus midazolam/ketamine combination for preoperative sedation prior to ...
Noha A. Osama, Sara R. Mahmoud, Abeer S. Salem, Dalia S. Tawfik   +3 more
doaj   +1 more source

High rates of midazolam injection among drug users in Bangkok, Thailand

Harm Reduction Journal, 2010
Background Reports from Thailand suggest that a growing number of people who inject drugs (IDU) are now injecting midazolam, a legal benzodiazepine with potent amnestic and ventilatory depressant effects.
Suwannawong Paisan, Hayashi Kanna, Fairbairn Nadia, Kiatying-Angsulee Niyada, Kerr Thomas, Kaplan Karyn, Lai Calvin, Wood Evan   +7 more
doaj   +1 more source