Results 21 to 30 of about 76,936 (284)

Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium?

PLoS ONE, 2022
Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to interfere with its ...
Katharina Rump, Caroline Holtkamp, Lars Bergmann, Hartmuth Nowak, Matthias Unterberg, Jennifer Orlowski, Patrick Thon, Zainab Bazzi, Maha Bazzi, Michael Adamzik, Björn Koos, Tim Rahmel   +11 more
doaj   +1 more source

Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway

Open Medicine, 2023
Non-small-cell lung cancer (NSCLC) is a dominating type of lung cancer with high morbidity and mortality. Midazolam has been reported to promote cell apoptosis in NSCLC, but the molecular mechanism of midazolam remains to be further explored.
Zhang Xiangchao, Han Zhe, Li Zhengjun, Wang Tao   +3 more
doaj   +1 more source

Transmucosal nasal drug delivery : systemic bioavailability of nasally applied midazolam [PDF]

, 2008
Transmucosal nasal drug delivery is a drug delivery option for challenging clinical situations where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable.
Suter-Zimmermann, Katja
core   +1 more source

Effects of midazolam vs morphine in patients with acute pulmonary edema with left ventricular systolic dysfunction: a secondary analysis of data from the MIMO trial

, 2023
Objetivo: El ensayo clínico MIMO demostró que los pacientes con edema agudo de pulmón (EAP) tratados con midazolam tenían menos eventos adversos graves (EAG) que los tratados con morfina.
Llorens, Pere, Et al., Burillo-Putze, Guillermo, Domínguez Rodríguez, Alberto, Calvo Rodríguez, Rafael, Suero Méndez, Coral, Gil, Víctor, Hernández Vaquero, Daniel, Piñera Salmerón, Pascual, MIMO (MIdazolam versus MOrphine), Martín Sánchez, Francisco Javier   +10 more
core   +2 more sources

Use of advanced intravenous conscious sedation techniques in complex oral surgery procedures: Comparison of midazolam, midazolam-propofol and midazolam-propofol-alfentanil combinations

, 2021
Aim: This retrospective observational study evaluates the safety and efficacy of intravenous sedation using midazolam only or combinations of two or three drugs including propofol and alfentanil for complex dental surgery such as implant placement or ...
Kingsford, NM, Mather, CI, Offord, DJ, Paterson, R, Robb, ND   +4 more
core   +1 more source

Individual differences in the effects of midazolam on anxiety-like behavior, learning, reward, and choice behavior in male mice

Frontiers in Psychiatry, 2023
IntroductionThe aim of the present study was to investigate the behavioral effects of the benzodiazepine midazolam in male mice, in models of anxiolysis, learning, and abuse-related effects.MethodsIn a first set of experiments, male Swiss mice were ...
Caio Jovita-Farias, Meagan E. Follett, Behaim C. Dias-Junior, Yasmim A. Serra, Natali D. Kisaki, Thaísa Barros-Santos, Nailton M. S. de Jesus, Isa R. S. Rodrigues, Larissa E. L. Macedo, Elena L. A. Malpezzi-Marinho, Alexandre J. Oliveira-Lima, Eduardo Ary Villela Marinho, James K. Rowlett, Lais F. Berro, Lais F. Berro   +14 more
doaj   +1 more source

Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats. [PDF]

, 2009
Some intravenous anesthetic agents such as midazolam are known to induce anterograde and retrograde amnesia. We analyzed the effect of midazolam by the conditioned taste aversion (CTA) acquisition and retention.
Yoshida, Harushi, Ishitobi, Shingo, Ayuse, Takao, Miyamoto, Takenori, Oi, Kumiko, Toda, Kazuo   +5 more
core   +1 more source

USE OF MIDAZOLAM IN PAEDIATRIC DENTISTRY

, 2023
Introduction and aim: Midazolam is a short-acting, effective sedative with a rapid onset and minimal side effects, belonging to the benzodiazepine group.
P Poláčková, J Vašáková, E Dokoupilová   +2 more
core   +1 more source

Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices

Scientific Reports, 2017
The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the current study was
Monika Balk, Harald Hentschke, Uwe Rudolph, Bernd Antkowiak, Berthold Drexler   +4 more
doaj   +1 more source

Midazolam alleviates cellular senescence in SH‐SY5Y neuronal cells in Alzheimer's disease

Brain and Behavior, 2023
Background Alzheimer's disease (AD) impacts the daily life of aging people. Oligomerized amyloid β (Aβ)‐associated neuronal senescence is involved in the pathological mechanism of AD.
Ping Wang, Peipei Wang, Hengfei Luan, Yong Wu, Ying Chen   +4 more
doaj   +1 more source