Results 51 to 60 of about 79,032 (289)

3D Printed Photon Shield Assembly for Low‐Noise Visual Stimulation During Two‐Photon Imaging in Mice

Advanced Materials Technologies, EarlyView.
We present the Photon Shield, an open‐hardware system for low‐noise two‐photon calcium imaging during visual stimulation in mice. Combining a 3D‐printed headplate and rail‐mounted shield substantially reduces stray‐light contamination, as quantitatively verified. Functional validation confirms reliable cortical responses. Open design files enable broad
Gergely Katona, Andrea Slézia, András Dávid, Ábel Petik, Dániel Hillier, István Ulbert, Attila Kaszás   +6 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

Advanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li, Yi‐Ge Guo, Xing Xu, Gui‐Lin Meng, Han Li, Liu‐Wei Chu, Xin‐Yuan Chen, Xiao‐Yun Guo, Tao Xu, Ti‐Fei Yuan, Ji Hu, Xiao‐Na Zhu   +11 more
wiley   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Anti-cancer effect of midazolam via downregulating YWHAH in papillary thyroid cancer cells

Discover Oncology
The work is aimed to investigate whether midazolam functions in thyroid cancer and reveal the potential mechanism of action. Cell viability was detected by CCK-8 method when treated by varying doses of midazolam to detect the cytotoxicity of midazolam on
Yang Li, Ai-Ping Tan, Yu-Shan Zhong
doaj   +1 more source

Comparison of the effects of midazolam, dexamethasone, ondansetron and propofol on the prevention and control of opioid-induced pruritus after spinal anaesthesia with bupivacaine combined with fentanyl in femoral fracture surgery

Advances in Human Biology, 2023
Introduction: The present study set out to compare the effects of midazolam, dexamethasone, ondansetron and propofol on the prevention and control of opioid-induced pruritus after spinal anaesthesia with bupivacaine and fentanyl as adjuvants in femoral ...
Hesameddin Modir, Esmail Moshiri, Mehran Azami, Amirreza Modir   +3 more
doaj   +1 more source

Efeitos do midazolam, propanolol e escopolamina em ratos submetidos ao modelo de condicionamento olfatório do medo [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Experiências de medo podem estabelecer memórias emocionais que resultam em mudanças comportamentais.
Kroon, Juliana Amorim Vieira
core  

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Effects of oropharyngeal neuromuscular stimulation on the volumetric enlarged and reduced tongue base in minipigs

The Anatomical Record, EarlyView.
Abstract Hypoglossal nerve or tongue protruding muscle stimulation is a current treatment option for obstructive sleep apnea. Thus, the present study analyzed 3D deformations of the volumetric enlarged and reduced tongue base upon oropharyngeal neuromuscular stimulation.
Sydney Chen, Doris Haydee Rosero Salazar, Zi‐Jun Liu   +2 more
wiley   +1 more source

NE contribution to rebooting unconsciousness caused by midazolam

eLife
The advent of midazolam holds profound implications for modern clinical practice. The hypnotic and sedative effects of midazolam afford it broad clinical applicability.
LeYuan Gu, WeiHui Shao, Lu Liu, Qing Xu, YuLing Wang, JiaXuan Gu, Yue Yang, ZhuoYue Zhang, YaXuan Wu, Yue Shen, Qian Yu, XiTing Lian, HaiXiang Ma, YuanLi Zhang, HongHai Zhang   +14 more
doaj   +1 more source