Results 131 to 140 of about 212,558 (382)

The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults

Frontiers in Human Neuroscience, 2016
Background: Methylphenidate (MPH) influences catecholaminergic signaling. Extant work examined the effects of MPH on the neural circuits of attention and cognitive control, but few studies have investigated the effect of MPH on the brain’s resting-state ...
Ryan Lewis Kline, Sheng eZhang, Olivia M Farr, Sien eHu, Laszlo eZaborzsky, Gregory R Samanez-Larkin, Gregory R Samanez-Larkin, Chiang-shan R Li, Chiang-shan R Li, Chiang-shan R Li   +9 more
doaj   +1 more source

Down-regulation of serotonergic genes expression in the raphe nuclei of midbrain under chronic social defeat stress in male mice [PDF]

, 2011
Background: There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety.
Maxim L. Filipenko, Natalia N. Kudryavtseva, Natalya P. Bondar, Ul’   +3 more
core   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. [PDF]

, 2011
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons.
Ahmadiantehrani, S, Barak, S, Kharazia, V, Ron, D   +3 more
core   +3 more sources

Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling

Neuropsychopharmacology, 2018
Astrocytes are ubiquitous CNS cells that support tissue homeostasis through ion buffering, neurotransmitter recycling, and regulation of CNS vasculature.
Wendy Xin, Kornel E. Schuebel, K. Jair, R. Cimbro, Lindsay M. De Biase, D. Goldman, A. Bonci   +6 more
semanticscholar   +1 more source

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation [PDF]

, 2006
The intrinsic properties of a neuron determine the translation of synaptic input to axonal output. It is this input– output relationship that is the heart of all nervous system activity.
Baines, Richard A., Hempel, Chris M., Li, L. (Lingjun), Liss, Birgit, Misonou, Hiroaki, Schulz, David J.   +5 more
core   +2 more sources

Target‐specific forebrain projections and appropriate synaptic inputs of hESC‐derived dopamine neurons grafted to the midbrain of parkinsonian rats

The Journal of comparative neurology, 2018
Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are a promising unlimited source of cells for cell replacement therapy in Parkinson's disease (PD).
Tiago Cardoso, Andrew F Adler, B. Mattsson, Deirdre B Hoban, Sara Nolbrant, Jenny Nelander Wahlestedt, A. Kirkeby, Shane Grealish, A. Björklund, M. Parmar   +9 more
semanticscholar   +1 more source

Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia

Annals of Neurology, EarlyView.
Objective Impaired ability to induce stepping after incomplete spinal cord injury (SCI) can limit the efficacy of locomotor training, often leaving patients wheelchair‐bound. The cuneiform nucleus (CNF), a key mesencephalic locomotor control center, modulates the activity of spinal locomotor centers via the reticulospinal tract.
Anna‐Sophie Hofer, Lennart H. Stieglitz, Marc Bolliger, Linard Filli, Adrian Cathomen, Romina Willi, Irina Lerch, Iris Krüsi, Melina Giagiozis, Christian Meyer, Martin Schubert, Michèle Hubli, Thomas M. Kessler, László Demkó, Christian R. Baumann, Lukas Imbach, Markus F. Oertel, Andrea Prusse, Alina Kiseleva, Luca Regli, Martin E. Schwab, Armin Curt   +21 more
wiley   +1 more source

Control of Behavioral Arousal and Defense by a Glutamatergic Midbrain-Amygdala Pathway in Mice

, 2022
Shang-Yi Chen, Jing Yao, Yuduan Hu, Huiyun Chen, Pei-Chang Liu, Wenfeng Wang, Yu-Hang Zeng, Cong-Wen Zhuang, Shun-Xing Zeng, Yueping Li, Liu-Yun Yang, Zixuan Huang, Kaiqi Huang, Zhen-Ting Lai, Yong-Huai Hu, Ping Cai, Li Chen, Siying Wu   +17 more
openalex   +1 more source