Results 121 to 130 of about 122,656 (259)
Epilepsia, EarlyView.Abstract Objective RAP‐219, a potent selective negative allosteric modulator (NAM) of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) associated with γ8 transmembrane AMPAR regulatory protein (TARPγ8), is in phase 3 development for refractory focal epilepsy. This study was undertaken to assess efficacy and motor function following
Jose A. Matta +5 more
wiley +1 more source
Status epilepticus: Updates on mechanisms and treatments
Epilepsia Open, EarlyView.Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley +1 more source
eLifeTo navigate real-world listening conditions, the auditory system relies on the integration of multiple sources of information. However, to avoid inappropriate cross-talk between inputs, highly connected neural systems need to strike a balance between ...
Baher A Ibrahim +5 more
doaj +1 more source
Epilepsia Open, EarlyView.Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher +11 more
wiley +1 more source
Midbrain Disorders of Eye Movements
, 2013 A unique feature of the midbrain is that it separates oculomotor regions in the pons devoted exclusively to the control of horizontal movements (PPRF) from regions in the rostral midbrain/diencephalic junction devoted to vertical movements (riMLF)
David M. Waitzman, MD, PhD
core
The translational asymmetry of corpus callosotomy: Two literatures that answered different questions
Epilepsia Open, EarlyView.Abstract Corpus callosotomy is an established palliative operation for drug‐resistant epilepsy dominated by drop attacks, and it is performed in three extents: anterior, usually of the anterior two‐thirds; total, in one or two stages; and selective posterior, which preserves the genu and rostral body.
Vitória Bernal Cavalcanti +1 more
wiley +1 more source
Research progress on the depth of anesthesia monitoring based on the electroencephalogram
Ibrain, Volume 11, Issue 1, Page 32-43, Spring 2025.Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Reward processing in children with affective dysregulation
JCPP Advances, EarlyView.Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner +11 more
wiley +1 more source