Results 131 to 140 of about 173,798 (309)

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Exploration of treatment strategies for cerebral cavernous malformations: two case reports on non-resection treatment and literature review

Frontiers in Oncology
BackgroundCavernous malformations are common vascular abnormalities of the central nervous system, but cavernous malformations of the cerebral aqueduct are rare. The choice of treatment is influenced by various factors.Case DescriptionWe report two cases
Yibo Han, Yibo Han, Dong Liang, Dong Liang, Jing Guo, Yibao Wang, Yong Wang   +6 more
doaj   +1 more source

Isolated Corticospinal Tract Lesions as an Early Manifestation of Adrenoleukodystrophy in Children

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Purpose X‐linked adrenoleukodystrophy (ALD) encompasses a wide range of neurological manifestations, classically described as distinct phenotypes including childhood cerebral adrenoleukodystrophy and adult‐onset adrenomyeloneuropathy (AMN).
Elle Winter, Amanda Nagy, Yedda Li, Otto Rapalino, Catherine L. Becker, Joseph Locascio, Camilo Jaimes, Florian Eichler   +7 more
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Cholinergic Modulation of Locomotion and Striatal Dopamine Release Is Mediated by α6α4* Nicotinic Acetylcholine Receptors [PDF]

, 2010
Dopamine (DA) release in striatum is governed by firing rates of midbrain DA neurons, striatal cholinergic tone, and nicotinic ACh receptors (nAChRs) on DA presynaptic terminals.
Drenan, Ryan M., Grady, Sharon R., Lester, Henry A., Marks, Michael J., McIntosh, J. Michael, McKinney, Sheri, Miwa, Julie M., Patzlaff, Natalie E., Steele, Andrew D.   +8 more
core  

Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space

Developmental Dynamics, EarlyView.
Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata   +2 more
wiley   +1 more source

Modulators of axonal growth and guidance at the brain midline with special reference to glial heparan sulfate proteoglycans

Anais da Academia Brasileira de Ciências, 2002
Bilaterally symmetric organisms need to exchange information between the left and right sides of their bodies to integrate sensory input and to coordinate motor control.
CAVALCANTE LENY A., GARCIA-ABREU JOSÉ, MOURA NETO VIVALDO, SILVA LUIZ CLAUDIO, WEISSMÜLLER GILBERTO   +4 more
doaj  

Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

eLife
To navigate real-world listening conditions, the auditory system relies on the integration of multiple sources of information. However, to avoid inappropriate cross-talk between inputs, highly connected neural systems need to strike a balance between ...
Baher A Ibrahim, Yoshitaka Shinagawa, Austin Douglas, Gang Xiao, Alexander R Asilador, Daniel A Llano   +5 more
doaj   +1 more source

Collateral afferent excitation of reticular formation of brain stem [PDF]

, 1951
MAGOUN, HW, STARZL, TE, TAYLOR, CW
core   +1 more source

Competence, specification and commitment in otic placode induction [PDF]

, 2000
The inner ear is induced from cranial ectoderm adjacent to the hindbrain. Despite almost a century of study, the molecular mechanisms of inner ear induction remain obscure. We have identified four genes expressed very early in the anlage of the inner ear,
Bronner-Fraser, Marianne, Groves, Andrew K.   +1 more
core