Midkine promotes PDGF-BB-induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathway. [PDF]
Physiol RepXu Y, Li W, Shi J, Guo Y.
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Bioinformatics study of bortezomib resistance-related proteins and signaling pathways in mantle cell lymphoma. [PDF]
Transl Cancer ResZheng L +4 more
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Single-cell analysis reveals shared and distinct molecular signatures in brain organoid models of neurodegeneration and neuroinflammation. [PDF]
Alzheimers Res TherLe Bars S +4 more
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RNA Interference based Midkine Gene Therapy for Hepatocellular Carcinoma. [PDF]
Asian Pac J Cancer PrevMamdouh S +6 more
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Metabolic reprogramming of arachidonic acid in clear cell renal carcinoma promotes an immunosuppressive microenvironment by activating MDK signaling pathway. [PDF]
Clin Exp MedYao J, Xu T, Wang C, Xie J, Jiang Q.
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A novel pH-sensitive nanoparticles encapsulating anti-PD-1 antibody and MDK-siRNA overcome immune checkpoint blockade resistance in HCC via reshaping immunosuppressive TME. [PDF]
J Exp Clin Cancer ResXu H +5 more
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AbstractMidkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. MK acts as a reparative neurotrophic factor in damaged peripheral nerves. A postulated role of MK in the degeneration and regeneration of sciatic nerves was explored by comparing wild‐type (Mdk+/+) mice with MK‐deficient (Mdk−/
Harutoshi, Sakakima +8 more
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Abstract Midkine (MDK), a heparin-binding growth factor, is highly expressed in pediatric ALL, neuroblastomas, and various solid tumors. Previous gene expression profiling studies conducted in our laboratory on a cohort of 220 children with B precursor ALL treated on Children’s Oncology Group (COG) clinical trials have shown that higher ...
Cheryl L. Willman +6 more
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