Results 1 to 10 of about 7,008 (224)

Midodrine for the early liberation from vasopressor support in the ICU (LIBERATE): a feasibility study. [PDF]

Pilot Feasibility Stud
Background Intravenous (IV) vasopressors are the mainstay of physiological support for hemodynamically unstable patients. However, the role of oral vasopressors remains unclear.
Kilcommons SJ, Hammal F, Opgenorth DL, Fiest KM, Karvellas CJ, Lau VI, MacIntyre E, Senaratne J, Slemko J, Sligl W, Zampieri F, Duquette D', Guan LT, Baig N, Bagshaw SM, Rewa OG.   +15 more
europepmc   +5 more sources

Need for Pretransplant Midodrine Does Not Negatively Impact Simultaneous Liver-kidney Transplant Outcomes. [PDF]

Transplantation Direct, 2021
BACKGROUND: Midodrine is often needed pretransplant to improve hemodynamics in simultaneous liver-kidney transplant candidates. Previous research has shown that patients requiring midodrine before kidney transplant alone have increased posttransplant ...
Barbas, Andrew, Barman, Pranab, Berg, Carl, King, Lindsay, McElroy, Lisa, Niedzwiecki, Donna, Parish, Alice, Patel, Yuval   +7 more
core   +3 more sources

Oral Midodrine Administration During the First 24 Hours of Sepsis to Reduce the Need of Vasoactive Agents: Placebo-Controlled Feasibility Clinical Trial

Critical Care Explorations, 2021
Objectives:. Our preliminary data and observational studies suggested an increasing “off label” use of oral midodrine as a vasopressor sparing agent in various groups of critically ill patients, including those with sepsis.
Amos Lal, MBBS, FACP, Vrinda Trivedi, MBBS, Mahrukh S. Rizvi, MD, Amy Amsbaugh, RRT, LRT, Melissa K Myers, MD, Khaled Saleh, MD, Rahul Kashyap, MBBS, MBA, Ognjen Gajic, MD, MSc, FCCP, FCCM   +7 more
doaj   +2 more sources

The Use of Midodrine as an Adjunctive Therapy to Liberate Patients from Intravenous Vasopressors: A Systematic Review and Meta-analysis of Randomized Controlled Studies

Cardiology and Therapy, 2023
Background Studies evaluating the role of midodrine as an adjunctive therapy to liberate patients with shock from intravenous (IV) vasopressors have yielded mixed results.
Mohamed Hamed, Sheref A. Elseidy, Ahmed Elkheshen, Jamal Maher, Adel Elmoghrabi, Ahmed Zaghloul, Andrew Panakos, Sidakpal Panaich, Marwan Saad, Ayman Elbadawi   +9 more
doaj   +2 more sources

Midodrine and clinical outcomes in patients on maintenance hemodialysis. [PDF]

Sci Rep
Patients on hemodialysis often experience intradialytic hypotension (IDH), contributing to increased cardiovascular disease and mortality. Midodrine, an α-1 adrenergic receptor agonist, is commonly prescribed for IDH treatment or prevention. However, the
Jeon J, Lim YJ, Kim BY, Choi JY, Do JY, Lee JE, Kang SH.   +6 more
europepmc   +2 more sources

Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery. [PDF]

JID Innov
Owing to the increasingly high volume of cutaneous and percutaneous procedures performed annually, the demand for local anesthesia has steadily risen. The gold-standard formulations for local anesthesia contain epinephrine at a concentration of 1:100,000
Dong J, Issa NT, Kaiser M, Gaumond SI, Solis M, Gil J, Kirsner RS, Davis SC, Jimenez JJ.   +8 more
europepmc   +2 more sources

Hemodynamic Effects of an Increased Midodrine Dosing Frequency

Critical Care Explorations, 2021
Objectives:. In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours.
Shea A. Macielak, PharmD, Nicholas J. Vollmer, PharmD, Natalie A. Haddad, PharmD, Christoph G. S. Nabzdyk, MD, Scott D. Nei, PharmD   +4 more
doaj   +1 more source

Calcitonin gene-related peptide predicts therapeutic response to midodrine hydrochloride in children with vasovagal syncope

Frontiers in Neuroscience, 2022
The vasoconstriction agent midodrine hydrochloride is a vital treatment for pediatric patients diagnosed with vasovagal syncope (VVS), although the efficacy is variable.
Lintian Li, Huacai Zhao, Xiuxiu Ma, Fuyong Jiao, Jing Lin   +4 more
doaj   +1 more source

Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors [PDF]

Endocrinology and Metabolism, 2022
Background Obesity, the prevalence of which is increasing due to the lack of exercise and increased consumption of Westernized diets, induces various complications, including ophthalmic diseases. For example, obesity is involved in the onset of cataracts.
Yong-Jik Lee, Yoo-Na Jang, Hyun-Min Kim, Yoon-Mi Han, Hong Seog Seo, Youngsub Eom, Jong-suk Song, Ji Hoon Jeong, Tae Woo Jung   +8 more
doaj   +1 more source

Acute midodrine overdose: a case report

Toxicology Communications, 2021
Midodrine is a prodrug metabolized to the peripheral acting alpha agonist desglymidodrine and is used to treat orthostatic hypotension. Reports of overdose are rare, consequently there is little guidance regarding treatment of overdose.
Jessica Peck, Steven D. Salhanick
doaj   +1 more source