Midodrine and clinical outcomes in patients on maintenance hemodialysis [PDF]
Scientific ReportsPatients on hemodialysis often experience intradialytic hypotension (IDH), contributing to increased cardiovascular disease and mortality. Midodrine, an α-1 adrenergic receptor agonist, is commonly prescribed for IDH treatment or prevention. However, the
Junseok Jeon +6 more
doaj +2 more sources
Impact of COVID‑19 infection on subsequent prescriptions of autonomic dysfunction pharmacotherapy: a nationwide propensity‑score‑matched Cohort study in Japan [PDF]
Annals of MedicineBackground Autonomic dysfunction, including orthostatic hypotension and postural tachycardia syndrome, has emerged as a COVID-19 complication.
Daisuke Miyamori, Masanori Ito
doaj +2 more sources
Midodrine for Sepsis Treatment and Early Vasopressor Weaning (MID-STEP): protocol for a pragmatic randomised clinical trial [PDF]
BMJ OpenIntroduction Sepsis is a global health priority with nearly 50 million cases annually. Cardiovascular dysfunction is common, frequently manifesting as hypotension that persists despite fluid resuscitation.
Amos Lal +20 more
doaj +2 more sources
Midodrine hydrochloride Form A, C12H19N2O4+·Cl− [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsThe crystal structure of midodrine hydrochloride Form A (systematic name: {[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]carbamoyl}methanaminium chloride, C12H19N2O4+·Cl−) has been solved and refined using synchrotron X-ray powder diffraction data, and ...
Jacob K. Salazar +3 more
doaj +2 more sources
Reversible cerebral vasoconstriction syndrome following ciltacabtagene autoleucel therapy for relapsed multiple myeloma: a case report [PDF]
Frontiers in ImmunologyCiltacabtagene autoleucel (cilta-cel), a BCMA-directed CAR-T therapy, is approved for relapsed/refractory multiple myeloma (RRMM). Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are common, but ...
Tuan L. Phan +20 more
doaj +2 more sources
Health Technology AssessmentBackground Orthostatic hypotension is a significant drop in blood pressure upon standing upright. It is very common and can result in symptoms such as postural dizziness, fainting and falls.
Helen Mossop +13 more
doaj +2 more sources
The effects of midodrine on patients with liver cirrhosis and refractory ascites: a randomized controlled trial [PDF]
African Journal of Gastroenterology and Hepatology, 2023 Background: Splanchnic vasodilation is a significant contributor to the development of ascites in cirrhotic patients. So, midodrine, an alpha-one agonist, may improve circulatory abnormality in cirrhotic patients via its vasoconstrictive action, thus ...
Essam Aboelnasr +3 more
doaj +1 more source
Hemodynamic Effects of an Increased Midodrine Dosing Frequency
Critical Care Explorations, 2021 Objectives:. In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours.
Shea A. Macielak, PharmD +4 more
doaj +1 more source
Transplantation Direct, 2021 Background. Midodrine is often needed pretransplant to improve hemodynamics in simultaneous liver-kidney transplant candidates. Previous research has shown that patients requiring midodrine before kidney transplant alone have increased posttransplant ...
Pranab M. Barman, MD +7 more
doaj +1 more source
Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors [PDF]
Endocrinology and Metabolism, 2022 Background Obesity, the prevalence of which is increasing due to the lack of exercise and increased consumption of Westernized diets, induces various complications, including ophthalmic diseases. For example, obesity is involved in the onset of cataracts.
Yong-Jik Lee +8 more
doaj +1 more source