Failure of pacemaker therapy in a pediatric patient with neurally mediated complete heart block and syncope: A case report [PDF]
Key Clinical Message Neurally mediated syncope (NMS) is a well‐known condition that can be subdivided into three subgroups: vasopressor type, cardioinhibitory type, and mixed type. While different degrees of sinus bradycardia occur at the time of syncope
Mohammad Dalili, Feisal Rahimpoor
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Oral midodrine for prophylaxis against post-spinal anesthesia hypotension during hip arthroplasty in elderly population: a randomized controlled trial [PDF]
Background We aimed to evaluate the efficacy of midodrine as a prophylaxis against post-spinal hypotension in elderly patients undergoing hip arthroplasty.
Sarah Amin+7 more
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Objectives:. Our preliminary data and observational studies suggested an increasing “off label” use of oral midodrine as a vasopressor sparing agent in various groups of critically ill patients, including those with sepsis.
Amos Lal, MBBS, FACP+7 more
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Midodrine for the early liberation from vasopressor support in the ICU (LIBERATE): a feasibility study [PDF]
Background Intravenous (IV) vasopressors are the mainstay of physiological support for hemodynamically unstable patients. However, the role of oral vasopressors remains unclear.
Sebastian J. Kilcommons+15 more
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Use of oral midodrine for weaning off norepinephrine in patients with septic shock
Background Early administration of norepinephrine in septic shock patients is linked to better survival rates. However, vasopressor dependence often occurs during the recovery phase, delaying ICU discharge. Objectives A comparative study was conducted on
Mohamed Obaya+3 more
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Systemic reviews and meta-analysis of the use of midodrine in hepatorenal syndrome [PDF]
Aims. This study analyzes the effectiveness of midodrine in reducing or managing Hepatorenal Syndrome (HRS). Design. A systematic review and meta-analysis were conducted to gather and assess relevant literature. The review included evaluating study aims,
Prem Balaji Reddy Lankapothu+3 more
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Safety of midodrine in patients with heart failure with reduced ejection fraction: a retrospective cohort study [PDF]
Background: Heart failure with reduced ejection fraction (HFrEF) poses significant health risks. Midodrine for maintaining blood pressure in HFrEF, requires further safety investigation.
Ming-Ju Wu+8 more
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Utility of an alpha-1 adrenergic agonist in the management of chylothorax: a case series and management algorithm [PDF]
Chylothorax is the accumulation of lymphatic fluid (chyle) within the pleural space. There are multiple causes, including traumatic and non-traumatic mechanisms.
Ruben Peralta+5 more
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Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review of studies before and during the COVID-19 pandemic [PDF]
BackgroundPostural Orthostatic Tachycardia Syndrome (POTS) is a complex form of dysautonomia that presents with abnormal autonomic reflexes upon standing, leading to symptoms such as lightheadedness, tachycardia, fatigue, and cognitive impairment.
Benjamin C. Pierson+11 more
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Therapeutic options for neurocardiogenic syncope: a meta-analysis of randomised trials with and without blinding [PDF]
Background Neurocardiogenic syncope is a common condition with significant associated psychological and physical morbidity. The effectiveness of therapeutic options for neurocardiogenic syncope beyond placebo remains uncertain.Methods The primary ...
Darrel P Francis+17 more
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