Acute midodrine overdose: a case report [PDF]
Toxicology Communications, 2021 Midodrine is a prodrug metabolized to the peripheral acting alpha agonist desglymidodrine and is used to treat orthostatic hypotension. Reports of overdose are rare, consequently there is little guidance regarding treatment of overdose.
Jessica Peck, Steven D. Salhanick
doaj +2 more sources
Impact of Adjuvant Use of Midodrine to Intravenous Vasopressors: A Systematic Review and Meta-Analysis [PDF]
Critical Care Research and Practice, 2021 Purpose. To evaluate the efficacy and safety of midodrine use in intensive care units (ICU) to facilitate weaning off intravenous vasopressors (IVV). Methods.
Ahmad Al-Abdouh +9 more
doaj +2 more sources
Use of oral midodrine for weaning off norepinephrine in patients with septic shock [PDF]
Egyptian Journal of Critical Care MedicineBackground Early administration of norepinephrine in septic shock patients is linked to better survival rates. However, vasopressor dependence often occurs during the recovery phase, delaying ICU discharge. Objectives A comparative study was conducted on
Mohamed Obaya +3 more
doaj +2 more sources
Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery [PDF]
JID InnovationsOwing to the increasingly high volume of cutaneous and percutaneous procedures performed annually, the demand for local anesthesia has steadily risen. The gold-standard formulations for local anesthesia contain epinephrine at a concentration of 1:100,000
Joanna Dong +8 more
doaj +4 more sources
The Use of Midodrine as an Adjunctive Therapy to Liberate Patients from Intravenous Vasopressors: A Systematic Review and Meta-analysis of Randomized Controlled Studies [PDF]
Cardiology and Therapy, 2023 Background Studies evaluating the role of midodrine as an adjunctive therapy to liberate patients with shock from intravenous (IV) vasopressors have yielded mixed results.
Mohamed Hamed +9 more
doaj +2 more sources
Oral Midodrine Administration During the First 24 Hours of Sepsis to Reduce the Need of Vasoactive Agents: Placebo-Controlled Feasibility Clinical Trial [PDF]
Critical Care Explorations, 2021 Objectives:. Our preliminary data and observational studies suggested an increasing “off label” use of oral midodrine as a vasopressor sparing agent in various groups of critically ill patients, including those with sepsis.
Amos Lal, MBBS, FACP +7 more
doaj +2 more sources
Midodrine for the early liberation from vasopressor support in the ICU (LIBERATE): a feasibility study [PDF]
Pilot and Feasibility StudiesBackground Intravenous (IV) vasopressors are the mainstay of physiological support for hemodynamically unstable patients. However, the role of oral vasopressors remains unclear.
Sebastian J. Kilcommons +15 more
doaj +2 more sources
Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature [PDF]
European Journal of Case Reports in Internal Medicine, 2022 Hypotension in patients with heart failure is much more frequent in daily clinical practice than the 10–15% reported in clinical trials. In patients with heart failure with reduced ejection fraction (HFrEF), hypotension frequently limits the initiation ...
Adnan Hajjiah +6 more
doaj +3 more sources
Fludrocortisone Is Associated With a Higher Risk of All‐Cause Hospitalizations Compared With Midodrine in Patients With Orthostatic Hypotension [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundOrthostatic hypotension causes ≈80 000 hospitalizations per year in the United States. Treatments for orthostatic hypotension include fludrocortisone, a mineralocorticoid analog that promotes sodium reabsorption; and midodrine, an α‐1 ...
Carlos G. Grijalva +3 more
doaj +2 more sources
Systemic reviews and meta-analysis of the use of midodrine in hepatorenal syndrome [PDF]
Romanian Medical JournalAims. This study analyzes the effectiveness of midodrine in reducing or managing Hepatorenal Syndrome (HRS). Design. A systematic review and meta-analysis were conducted to gather and assess relevant literature. The review included evaluating study aims,
Prem Balaji Reddy Lankapothu +3 more
doaj +3 more sources