Results 21 to 30 of about 4,930 (199)

Acute midodrine overdose: a case report

Toxicology Communications, 2021
Midodrine is a prodrug metabolized to the peripheral acting alpha agonist desglymidodrine and is used to treat orthostatic hypotension. Reports of overdose are rare, consequently there is little guidance regarding treatment of overdose.
Jessica Peck, Steven D. Salhanick
doaj   +1 more source

Midodrine for Sepsis Treatment and Early Vasopressor Weaning (MID-STEP): protocol for a pragmatic randomised clinical trial. [PDF]

BMJ Open
Introduction Sepsis is a global health priority with nearly 50 million cases annually. Cardiovascular dysfunction is common, frequently manifesting as hypotension that persists despite fluid resuscitation.
Tekin A, Halpern G, Gowda D, Bansal V, Schuchard A, Joguncic A, Schulte P, Odeyemi YE, Ahmad S, Madsen B, Rizwan Z, Barreto EF, Reddy S, Bhavsar V, Sanghavi D, Domecq Garces JP, Khan SA, Shiari A, Cartin-Ceba R, Gajic O, Lal A.   +20 more
europepmc   +2 more sources

Impact of Adjuvant Use of Midodrine to Intravenous Vasopressors: A Systematic Review and Meta-Analysis

Critical Care Research and Practice, 2021
Purpose. To evaluate the efficacy and safety of midodrine use in intensive care units (ICU) to facilitate weaning off intravenous vasopressors (IVV). Methods.
Ahmad Al-Abdouh, Sadam Haddadin, Atul Matta, Ahmad Jabri, Mahmoud Barbarawi, Waiel Abusnina, Qais Radideh, Mohammed Mhanna, Dante A. Suffredini, Erin D. Michos   +9 more
doaj   +1 more source

Effect of Oral Vasopressors Used for Liberation from Intravenous Vasopressors in Intensive Care Unit Patients Recovering from Spinal Shock: A Randomized Controlled Trial

Critical Care Research and Practice, 2022
Background. Early vasopressor utilization has been associated with improved outcomes of patients with spinal shock; however, there are difficulties in weaning off vasopressors, in which patients after recovery from spinal shock develop a state of ...
Ahmed Talaat Ahmed Ali, Mervat Anwar Abd EL-Aziz, Ahmed Mohamed Abdelhafez, Amr Mohamed Ahmed Thabet   +3 more
doaj   +1 more source

Potential risks in using midodrine for persistent hypotension after cardiac surgery: a comparative cohort study

Annals of Intensive Care, 2020
Background Persistent hypotension is a frequent complication after cardiac surgery with cardiopulmonary bypass (CPB). Midodrine, an orally administered alpha agonist, could potentially reduce intravenous vasopressor use and accelerate ICU discharge of ...
Jan-Alexis Tremblay, Philippe Laramée, Yoan Lamarche, André Denault, William Beaubien-Souligny, Anne-Julie Frenette, Loay Kontar, Karim Serri, Emmanuel Charbonney   +8 more
doaj   +1 more source

Control, Fludrocortisone or Midodrine for the treatment of Orthostatic Hypotension: CONFORM-OH pilot RCT and economic evaluation.

Health Technol Assess
Background Orthostatic hypotension is a significant drop in blood pressure upon standing upright. It is very common and can result in symptoms such as postural dizziness, fainting and falls.
Mossop H, Al Ashmori S, Sotire T, Clark E, Watson G, Witham M, Vale L, McGregor N, Phillipson J, Wason JM, Yarnall AJ, Hancock H, Kenny RA, Frith J.   +13 more
europepmc   +2 more sources

Hyponatremia in Cirrhosis: Clinical Outcomes and Comparative Analysis of Different Treatment Approaches [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Hyponatremia is a common electrolyte disturbance in cirrhotic patients, resulting from impaired renal water excretion due to elevated levels of Antidiuretic Hormone (ADH) and is strongly associated with morbidity and mortality.
Kranthi Dandi, Debabrata Banerjee, Amol S Dahale, Abhijeet S Karad, Yogesh S Bade   +4 more
doaj   +1 more source

Predicting Therapeutic Efficacy of Pharmacological Treatments in Children with Postural Orthostatic Tachycardia Syndrome: A Mini-Review

Children, 2023
Postural orthostatic tachycardia syndrome (POTS) is common in children, with an excessive increment in heart rate when moving from the supine to upright position. It has significant negative impacts on the daily life of pediatric patients.
Siying Fan, Yaxi Cui, Ying Liao, Hongfang Jin   +3 more
doaj   +1 more source

Treatment of prolonged clonidine-induced autonomic instability with midodrine: a case report about a new approach or a cautionary tale?

Emergency and Critical Care Medicine, 2023
. Background. Clonidine is a centrally acting α2 adrenergic and imidazoline-1 receptor agonist that can cause somnolence, bradycardia, and hypotension within several hours of ingestion.
Saada Malouf, Catherine Henry, Lara Pemberton, Joe-Anthony Rotella   +3 more
doaj   +1 more source

Use of Midodrine for Intraoperative Hemostasis in Cutaneous and Percutaneous Surgery. [PDF]

JID Innov
Owing to the increasingly high volume of cutaneous and percutaneous procedures performed annually, the demand for local anesthesia has steadily risen. The gold-standard formulations for local anesthesia contain epinephrine at a concentration of 1:100,000
Dong J, Issa NT, Kaiser M, Gaumond SI, Solis M, Gil J, Kirsner RS, Davis SC, Jimenez JJ.   +8 more
europepmc   +2 more sources