Results 1 to 10 of about 13,742 (189)

Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity. [PDF]

PLoS ONE, 2013
The steroid receptor antagonist mifepristone is used as an anti-cancer agent, eliciting both cytostatic and cytotoxic effects on malignant cells. However, the metabolic effects of long-term treatment with mifepristone have remained unclear.
Takeshi Hashimoto, Junsuke Igarashi, Arif U Hasan, Koji Ohmori, Masakazu Kohno, Yukiko Nagai, Tetsuo Yamashita, Hiroaki Kosaka   +7 more
doaj   +3 more sources

What motivates primary care providers to prescribe mifepristone medication abortion? Results of a qualitative investigation in Canada. [PDF]

BMC Prim Care
Munro S, Ennis M, Wahl K, Williams A.
europepmc   +2 more sources

Mifepristone Increases Life Span of Virgin Female Drosophila on Regular and High-fat Diet Without Reducing Food Intake

Frontiers in Genetics, 2021
Background: The synthetic steroid mifepristone is reported to have anti-obesity and anti-diabetic effects in mammals on normal and high-fat diets (HFD). We previously reported that mifepristone blocks the negative effect on life span caused by mating in ...
Gary N. Landis, Tyler A. U. Hilsabeck, Tyler A. U. Hilsabeck, Hans S. Bell, Tal Ronnen-Oron, Lu Wang, Devon V. Doherty, Felicia I. Tejawinata, Katherine Erickson, William Vu, Daniel E. L. Promislow, Daniel E. L. Promislow, Pankaj Kapahi, John Tower   +13 more
doaj   +1 more source

Direct Effects of Mifepristone on Mice Embryogenesis: An In Vitro Evaluation by Single-Embryo RNA Sequencing Analysis

Biomedicines, 2023
The clinical use of mifepristone for medical abortions has been established in 1987 in France and since 2000 in the United States. Mifepristone has a limited medical period that lasts
Yu-Ting Su, Jia-Shing Chen, Kuo-Chung Lan, Yung-Kuo Lee, Tian-Huei Chu, Yu-Cheng Ho, Cheng-Chun Wu, Fu-Jen Huang   +7 more
doaj   +1 more source

Dhr96[1] mutation and maternal tudor[1] mutation increase life span and reduce the beneficial effects of mifepristone in mated female Drosophila.

PLoS ONE, 2023
Mating and receipt of male Sex Peptide hormone cause increased egg laying, increased midgut size and decreased life span in female Drosophila. Feeding mated females with the synthetic steroid mifepristone decreases egg production, reduces midgut size ...
Gary N Landis, Hans S Bell, Oscar Peng, Brett Bognar, Andy Tong, Tomás D Manea, Hanmei Bao, Xianlin Han, John Tower   +8 more
doaj   +1 more source

Clinical evaluation of high-intensity focused ultrasound ablation combined with mifepristone and levonorgestrel-releasing intrauterine system to treat symptomatic adenomyosis

International Journal of Hyperthermia, 2023
Objective To evaluate the clinical efficacy of the combination of high-intensity focused ultrasound (HIFU), mifepristone, and levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis treatment.Methods HIFU treatment was performed in 123 ...
Hui Zhu, Qimin Ma, Guoling Dong, Lijun Yang, Yang Li, Shumin Song, Yanchao Mu   +6 more
doaj   +1 more source

Antitumor effect of mifepristone on human endometrial stromal cell line [PDF]

Vojnosanitetski Pregled, 2021
Background/Aim. The main cause for development of endometrial hyperplasia is unopposed effect of estrogen on endometrial cells. The aim of our study was to investigate and compare cytotoxic and apoptotic effects of mifepristone on human endometrial ...
Luković Jovan, Milosavljević Zoran, Zečević-Luković Tanja, Mitrović Marina, Anđelković Marija, Zelen Ivanka, Stanojević-Pirković Marijana, Nikolić Ivana   +7 more
doaj   +1 more source

Mifepristone induced liver injury in a patient with Cushing syndrome: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Mifepristone, also known as RU-486, is an anti-progestational steroid with similar chemical structure to anabolic steroids. Given as a single dose in conjunction with misoprostol, mifepristone is used to induce medical abortion.
Taylor A. Ault, David R. Braxton, Rebecca A. Watson, Alan O. Marcus, Tse-Ling Fong   +4 more
doaj   +1 more source

Mifepristone increases the cytotoxicity of uterine natural killer cells by acting as a glucocorticoid antagonist via ERK activation. [PDF]

PLoS ONE, 2012
Mifepristone (RU486), a potent antagonist of progesterone and glucocorticoids, is involved in immune regulation. Our previous studies demonstrated that mifepristone directly augments the cytotoxicity of human uterine natural killer (uNK) cells.
Yuezhou Chen, Yan Wang, Yaling Zhuang, Feng Zhou, Lili Huang   +4 more
doaj   +1 more source

Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity

Frontiers in Aging, 2022
Mifepristone dramatically increases the life span of mated female Drosophila while reducing the expression of innate immune response genes. Previous results indicated that mifepristone also reduced the load of aero-tolerant bacteria in mated females ...
Gary N. Landis, Luke Riggan, Hans S. Bell, William Vu, Tianyi Wang, Ina Wang, Felicia I. Tejawinata, Sebastian Ko, John Tower   +8 more
doaj   +1 more source