Results 21 to 30 of about 8,906 (137)

Optimized pharmacological control over the AAV-Gene-Switch vector for regulable gene therapy

Molecular Therapy: Methods & Clinical Development, 2021
Gene therapy in its current design is an irreversible process. It cannot be stopped in case of unwanted side effects, nor can expression levels of therapeutics be adjusted to individual patient’s needs.
Shi Cheng, Marcel M. van Gaalen, Mathias Bähr, Enrique Garea-Rodriguez, Sebastian Kügler   +4 more
doaj   +1 more source

Demographic Factors Influencing Eligibility for EMA in South Australia. [PDF]

Aust N Z J Obstet Gynaecol
ABSTRACT Background Early medical abortion (EMA) can be performed by administration of mifepristone and misoprostol in an outpatient setting prior to 63 days gestation in Australia. While this is a flexible, efficacious and safe option for abortion, it requires early identification of pregnancy and efficient access to a clinical service. Outpatient EMA
Slade L, Louise J, D'Onise K, Dodd J.
europepmc   +2 more sources

How did the introduction of mifepristone impact the availability of abortion care in Ottawa? A qualitative study with abortion patients

FACETS, 2020
In 2017, mifepristone and misoprostol became available for early pregnancy termination as the combination pack Mifegymiso® in Ottawa, Ontario, Canada.
Kathryn J. LaRoche, Isabelle N. Labeca-Gordon, Angel M. Foster   +2 more
doaj   +1 more source

Outpatient cervical ripening with Foley balloon or mifepristone: Insights into the time taken to reach the active phase of labor. [PDF]

Int J Gynaecol Obstet
Abstract Objective To estimate the median time elapsed between the start of cervical ripening and the diagnosis of the active phase of labor, according to maternal and pregnancy characteristics, in low‐risk pregnancies submitted to outpatient cervical ripening with a Foley balloon catheter or oral mifepristone.
Carvalho-Afonso M, Antunes M, Fonseca A, Ayres-de-Campos D.   +3 more
europepmc   +2 more sources

Cocktail treatment by GnRH-antagonist, letrozole, and mifepristone for the prevention of ovarian hyperstimulation syndrome: a prospective randomized trial

Gynecological Endocrinology, 2023
Objective This study is aimed to determine the efficacy of a cocktail style treatment by combining GnRH-antagonist, letrozole, and mifepristone on the prevention of ovarian hyperstimulation syndrome (OHSS) in high-risk women.Methods This prospective ...
Qianrong Qi, Yi Xia, Jin Luo, Yaqin Wang, Qingzhen Xie   +4 more
doaj   +1 more source

A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects

Fly, 2022
Mifepristone increases life span in female Drosophila melanogaster, and its molecular target(s) remain unclear. Here small molecule and genetic interventions were tested for ability to mimic mifepristone, or to decrease life span in a way that can be ...
Gary N. Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S. Bell, John Tower   +6 more
doaj   +1 more source

Mifepristone-Induced Hypothyroidism

Journal of Investigative Medicine High Impact Case Reports, 2023
Medications are known to affect the thyroid physiology and are a known cause of hypothyroidism. There is an ever-growing list of medications that affect the thyroid by 1 or more mechanisms.
Niketa Kalara MD, Alex Manzano MD
doaj   +1 more source

A retrospective study of estrogen in the pretreatment for medical management of early pregnancy loss and the inference from intrauterine adhesion

European Journal of Medical Research, 2022
Background Estrogen has been usually used in clinic for medical pretreatment of early pregnancy loss. There was little reported the effect of estrogen combined with prostaglandin analogs in the medical management of early pregnancy loss.
Chaoxia Cao, Qin Zhou, Zhuoying Hu, Chunmei Shu, Mingju Chen, Xiujun Yang   +5 more
doaj   +1 more source

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Molecular Oncology, 2016
The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds and
Lei Zhang, Maria B. Hapon, Alicia A. Goyeneche, Rekha Srinivasan, Carlos D. Gamarra-Luques, Eduardo A. Callegari, Donis D. Drappeau, Erin J. Terpstra, Bo Pan, Jennifer R. Knapp, Jeremy Chien, Xuejun Wang, Kathleen M. Eyster, Carlos M. Telleria   +13 more
doaj   +1 more source

Selection, counterselection, and conditional gene expression for genetic biocontrol of insects

Insect Science, EarlyView.
Selection, counterselection, and conditional expression can be used for sex separation. Selection (S) and counterselection (CS) genes are linked to the sex chromosomes (e.g., the X and Y chromosomes) to confer sex‐specific selection or counterselection based on the presence or absence of the S or CS genes.
Melanie Hempel, Zhijian Tu
wiley   +1 more source