Results 61 to 70 of about 13,742 (189)
Advanced Science, Volume 13, Issue 6, 30 January 2026.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.TH is expected to be a novel therapeutic strategy for hydrocephalus and neurological dysfunction post IVH. TH alleviates hydrocephalus post IVH by enhancing drainage of the glymphatic‐meningeal lymphatic‐deep cervical lymphatic system, which is the connection between the central nervous system and peripheral lymphatic system.
Yijian Yang +16 more
wiley +1 more source
Cancer Cell International, 2009 Background The prototypical antiprogestin mifepristone exhibits potent growth inhibition activity towards ovarian cancer cells in vitro and in vivo.
Seidel Erin E +3 more
doaj +1 more source
Mifepristone and rapamycin have non-additive benefits for life span in mated female Drosophila
FlyThe drugs mifepristone and rapamycin were compared for their relative ability to increase the life span of mated female Drosophila melanogaster. Titration of rapamycin indicated an optimal concentration of approximately 50 μM, which increased median life
Gary N. Landis +6 more
doaj +1 more source
BMC Cancer, 2019 Background Previous work in our laboratory demonstrated that antiprogestin mifepristone impairs the growth and adhesion of highly metastatic cancer cells, and causes changes in their cellular morphology.
Sabrina J. Ritch +3 more
doaj +1 more source