Results 71 to 80 of about 4,386 (137)

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

open access: yesAdvanced Science, Volume 13, Issue 54, 28 September 2026.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang   +4 more
wiley   +1 more source

Oxycodone alleviates mifepristone‐stimulated human endometrial stromal cell injury by activating the Keap1/Nrf2/HO‐1 signaling pathway

open access: yesImmunity, Inflammation and Disease, 2023
Background Endometrial injury is a common disease in women caused by intrauterine inflammation, infections, and endocrine disorders. Human endometrial stromal cells (hEndoSCs) can maintain endometrial homeostasis and play an important role in repairing ...
Aibing Zhu, Fei Yao, Mingkun Shen
doaj   +1 more source

Multi‐Mechanistic Effects of Xylopia aethiopica Fruits on Uterine Fibroids: Insights From In Vivo and In Silico Evidence

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Xylopia aethiopica fruit extract modulates progesterone and estradiol levels in monosodium glutamate‐induced uterine fibroid models. In silico analyses reveal strong binding of its phytochemicals to progesterone, estrogen, VEGFR2, and TGF‐β receptors, indicating multi‐target anti‐fibroid actions involving hormonal regulation, anti‐angiogenesis, and ...
Adedokun Oluwasegun   +7 more
wiley   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao   +4 more
wiley   +1 more source

Mifepristone Improves Octreotide Efficacy in Resistant Ectopic Cushing’s Syndrome

open access: yesCase Reports in Endocrinology, 2016
A 30-year-old Caucasian man presented with severe Cushing’s syndrome (CS) resulting from ectopic adrenocorticotropin syndrome (EAS) from a metastatic pancreatic neuroendocrine tumor.
Andreas G. Moraitis, Richard J. Auchus
doaj   +1 more source

ALTERNATIVE APPROACHES TO MEDICAL ABORTION [PDF]

open access: yesTrakia Journal of Sciences
Medical abortion involving various pharmacological agents has demonstrated high levels of complete uterine evacuation. Alternative approaches involving letrozole, mifepristone, methotrexate used synergically with misoprostol are non-invasive elective ...
K. Telbiyska, M. Angelova
doaj   +1 more source

Mifepristone as a Potential Therapy to Reduce Angiogenesis and P-Glycoprotein Associated With Glioblastoma Resistance to Temozolomide

open access: yesFrontiers in Oncology, 2020
Glioblastoma, the most common primary central nervous system tumor, is characterized by extensive vascular neoformation and an area of necrosis generated by rapid proliferation.
Monserrat Llaguno-Munive   +7 more
doaj   +1 more source

Incidence and preventability of severe early pregnancy morbidity at a tertiary referral center

open access: yesPregnancy, Volume 2, Issue 5, September 2026.
Abstract Objectives To identify the incidence of severe early pregnancy morbidity (SEPM) by adapting severe maternal morbidity (SMM) definitions to pregnancies <24 weeks; secondarily, to assess preventability of these events using a validated tool Methods This is a retrospective cohort study of pregnant patients at a single tertiary care institution ...
Susan E. Nourse   +7 more
wiley   +1 more source

Reproductive outcomes following surgical removal of uterine fibroids

open access: yesМедицинский совет, 2019
The cohort prospective comparative study investigated the efficacy of mifepristone use in patients after surgical treatment of uterine myoma. It was shown that the use of mifepristone at a dose of 50 mg/day in a continuous mode for 3 months after ...
A. E. Mitichkin   +7 more
doaj   +1 more source

Mifepristone: an alternate to dinoprostone in induction of labour [PDF]

open access: yes, 2017
Background: To assess and compare the efficacy, safety and fetomaternal outcome of mifepristone versus dinoprostone in priming the cervix and in inducing labour in pregnant women at term.Methods: This is a prospective comparative study done in Chettinad ...
Sailatha R.   +11 more
core   +1 more source

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